DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usf and Tfeb

DIOPT Version :9

Sequence 1:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_001020878.1	Gene:	Tfeb / 316214	RGDID:	1309583	Length:	535	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	72/394 - (18%)
Similarity:	119/394 - (30%)	Gaps:	161/394 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EFGSSTSNTNTSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQSLILTSDTG 76
            :|.:..|....|..|.        |.|.||:.  ..|                     :|::..|
  Rat   162 KFAAHVSPAQGSPKPP--------PAASPGVR--AGH---------------------VLSTSAG 195

  Fly    77 NPLMNSQGAQIFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNNLQLPTG-CEIYL 140
            |...||..|.:.::...::..||     .|......|..:..:.| .:|:||.|.|.:. ..:|
  Rat   196 NSAPNSPMAMLHISSNPEKEFDD-----VIDNIMRLDSVLGYINP-EMQMPNTLPLSSSHLNVY- 253

  Fly   141 VKETGSLMGEPPTKAAIKLELDTLSEKPLLPSVTTSSSTQSAVITAQTVNPPIPGNINTTTSTTS 205
                   .|:|...|:             |..||:||               .|.::......|.
  Rat   254 -------SGDPQVTAS-------------LVGVTSSS---------------CPADLTQKRELTD 283

  Fly   206 TTTTTSVLYGSHGNGHGHGHAHAQARSQPESAGQTPSSKLEAYKKRDDKRRATHNEVERRRRDKI 270
                                  |::|:..:..           :|:|:     ||.:|||||..|
  Rat   284 ----------------------AESRALAKER-----------QKKDN-----HNLIERRRRFNI 310

  Fly   271 NSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSGRAPPND-----SKSQ 330
            |..|.:|..::|.                                        .||     :|..
  Rat   311 NDRIKELGMLIPK----------------------------------------ANDLDVRWNKGT 335

  Fly   331 ILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRLKRQQQLQERFHTAGGRSTFNVT 395
            ||..:.:||:.||.::...|:....:..|..:|:.|...:..|    ::|.|.|.....|...|.
  Rat   336 ILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQEL----EMQARVHGLPTTSPSGVN 396

  Fly   396 LNSL 399
            :..|
  Rat   397 MAEL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usf	NP_572167.3	HLH	255..343	CDD:278439	19/92 (21%)
Tfeb	NP_001020878.1	MITF_TFEB_C_3_N	63..220	CDD:292573	17/93 (18%)
		HLH	292..352	CDD:238036	23/115 (20%)
		DUF3371	380..516	CDD:288684	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810