DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usf and Tfe3

DIOPT Version :9

Sequence 1:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_766060.2	Gene:	Tfe3 / 209446	MGIID:	98511	Length:	572	Species:	Mus musculus

Alignment Length:	413	Identity:	83/413 - (20%)
Similarity:	132/413 - (31%)	Gaps:	128/413 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 STSPSSVNISNANPTAGPGLMTITNHHTADLSEALV------------HSSFANGQQSLILTSDT 75
            |.:|:|..||....:||.  .|::....|.:...::            |...|..||.....|.|
Mouse   143 SPAPASPAISVIGVSAGG--HTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTT 205

  Fly    76 GNPLMNSQGAQIFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNNLQLPTGCEIYL 140
            ..|.:.||                     .:...||         ||:.|     .||.....:.
Mouse   206 LGPKLASQ---------------------ALTPPPG---------PSSAQ-----PLPAPETAHA 235

  Fly   141 VKETGSLMGEPPTKAAI----KLELDTLSEKPL-------------LPSVTTSSSTQSAVITAQT 188
            ...|||....|.....|    :.|:|.:.::.:             ||..|......|.:
Mouse   236 TGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTL----- 295

  Fly   189 VNPPIPGNINTTTSTTSTTTTTSVLYGSHGNGHGHGHAHAQARSQPESAGQTPSSKLEAYKKRDD 253
               |:.||:....|:....|....:..|         ..|:..:......:|.:..|...:::.|
Mouse   296 ---PVSGNLLDVYSSQGVATPAITVSNS---------CPAELPNIKREISETEAKALLKERQKKD 348

  Fly   254 KRRATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSS 318
                .||.:|||||..||..|.:|..::|.          |..|....
Mouse   349 ----NHNLIERRRRFNINDRIKELGTLIPK----------SNDPEMRW----------------- 382

  Fly   319 SGRAPPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRLKRQQQLQERF 383
                    :|..||..:.:||:.:|.|....:|......||..:|::|:..:..|:.|.|:.
Mouse   383 --------NKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIH--- 436

  Fly   384 HTAGGRSTFNVTLNSLNSSATSD 406
               |.....|..|.||.:|:.||
Mouse   437 ---GLPVPPNPGLLSLTTSSVSD 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usf	NP_572167.3	HLH	255..343	CDD:278439	19/87 (22%)
Tfe3	NP_766060.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..152		3/8 (38%)
		MITF_TFEB_C_3_N	112..264	CDD:318217	32/157 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..248		13/72 (18%)
		Strong transcription activation domain. /evidence=ECO:0000255	259..270		2/10 (20%)
		HLH	343..403	CDD:238036	22/98 (22%)
		Leucine-zipper	408..429		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..495		7/18 (39%)
		DUF3371	<518..570	CDD:314681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840