DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usf and Srebf1

DIOPT Version :9

Sequence 1:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_035610.1	Gene:	Srebf1 / 20787	MGIID:	107606	Length:	1134	Species:	Mus musculus

Alignment Length:	351	Identity:	75/351 - (21%)
Similarity:	119/351 - (33%)	Gaps:	112/351 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 HSLLPSNLQ--LPNNLQLPTGCEIYLVKETGSLMGEPPTKAAIKLELDTLSEKPLLPSVTTSSST 179
            :|.|||...  ||.|.|.|.. .:.|....|.|    || .|:..::.:|:.:..||:   |::.
Mouse   162 YSSLPSGFSGTLPGNTQQPPS-SLPLAPAPGVL----PT-PALHTQVQSLASQQPLPA---SAAP 217

  Fly   180 QSAVITAQTVNPPIP-------------GNINTTTSTTSTTTTTSVLYGSHGNGHGHGHAHAQAR 231
            ::..:|:|....|:.             ..:.|....|..|...|.|        ..|.|.....
Mouse   218 RTNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTL--------APGTAVQAGP 274

  Fly   232 SQPESAGQT--------------PSSKLEAYKK-------RDDKRRATHNEVERRRRDKINSWIF 275
            .|...:|.|              |..:|.|..|       |.:||.| ||.:|:|.|..||..|.
Mouse   275 LQTLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTA-HNAIEKRYRSSINDKIV 338

  Fly   276 KLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSGRAPPNDSKSQILIKACEYIK 340
            :||:::..       :||..                               :||.:|.||.:||:
Mouse   339 ELKDLVVG-------TEAKL-------------------------------NKSAVLRKAIDYIR 365

  Fly   341 SMQGEIDTLRDCLRETDSLRASNQALREE---LDRLKRQQQLQERFHTAGGRSTFNVTLNSLNSS 402
            .:|                 .|||.|::|   |....:.:.|::.....|.....:|::..:...
Mouse   366 FLQ-----------------HSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPE 413

  Fly   403 ATSDLFEGIDTTPNLAAVSSLGFGKR 428
            ....|........:.:..|.|.||.|
Mouse   414 VVETLTPPPSDAGSPSQSSPLSFGSR 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usf	NP_572167.3	HLH	255..343	CDD:278439	21/87 (24%)
Srebf1	NP_035610.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..60
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P36956	27..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..73
		ERbeta_N	114..210	CDD:289279	16/53 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		8/29 (28%)
		Interaction with LMNA. /evidence=ECO:0000269\|PubMed:11929849	227..487		54/277 (19%)
		HLH	315..372	CDD:238036	25/112 (22%)
		Leucine-zipper	367..388		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..468		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940