DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usf and Mitf

DIOPT Version :9

Sequence 1:NP_572167.3 Gene:Usf / 31384 FlyBaseID:FBgn0029711 Length:437 Species:Drosophila melanogaster
Sequence 2:NP_001106669.1 Gene:Mitf / 17342 MGIID:104554 Length:526 Species:Mus musculus


Alignment Length:474 Identity:81/474 - (17%)
Similarity:135/474 - (28%) Gaps:182/474 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 HKRPRLNMEFGSSTSNTNTSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQS 68
            |:.|:...|..|....:::|...|..    :.|......||         |..|:.......|..
Mouse    18 HEEPKTYYELKSQPLKSSSSAEHSGA----SKPPLSSSTMT---------SRILLRQQLMREQMQ 69

  Fly    69 LILTSDTGNPLMNSQGAQIFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNNLQLP 133
               ..:........|.||..            |:...:.|.|..::.:.:.|||..|:|      
Mouse    70 ---EQERREQQQKLQAAQFM------------QQRVAVSQTPAINVSVPTTLPSATQVP------ 113

  Fly   134 TGCEIYLVKETGSLMGEPPTKAAIKLELDTLSEKPLLPSVTTSSSTQSAVITAQTVN-------P 191
                :.::|....|  |.|||..|: :......|..| |.|.::...|.|:::...|       |
Mouse   114 ----MEVLKVQTHL--ENPTKYHIQ-QAQRHQVKQYL-STTLANKHASQVLSSPCPNQPGDHAMP 170

  Fly   192 PIPGNINTTTSTTSTTTTTSVLYGSHGNGHGHGHAHAQARSQPESAGQTPSSK------------ 244
            |:||      |:...:....:...|:...........|:|::.|..|....|:            
Mouse   171 PVPG------SSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDD 229

  Fly   245 --------------------------------LEAYKK--------------------------- 250
                                            ::.|..                           
Mouse   230 IISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTA 294

  Fly   251 -------------RDDKRRATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGS 302
                         ::.:::..||.:|||||..||..|.:|..::|.          |..|.... 
Mouse   295 CIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPK----------SNDPDMRW- 348

  Fly   303 TSTNGSSHSKGNASSSSGRAPPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALR 367
                                    :|..||..:.:||:.:|.|....:|.......|..:|:.| 
Mouse   349 ------------------------NKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHL- 388

  Fly   368 EELDRLKRQQQL--QERFH 384
                 |.|.|:|  |.|.|
Mouse   389 -----LLRVQELEMQARAH 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UsfNP_572167.3 HLH 255..343 CDD:278439 19/87 (22%)
MitfNP_001106669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..54 6/37 (16%)
MITF_TFEB_C_3_N 56..194 CDD:406384 33/172 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..179 7/29 (24%)
Transactivation. /evidence=ECO:0000250 224..291 1/66 (2%)
bHLHzip_MITF 300..403 CDD:381496 32/144 (22%)
Leucine-zipper. /evidence=ECO:0000305|PubMed:23207919 374..395 6/26 (23%)
DUF3371 397..522 CDD:403149 3/6 (50%)
DNA binding regulation. /evidence=ECO:0000250 401..431 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..526
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1318
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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