DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usf and srebf2

DIOPT Version :9

Sequence 1:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_001082935.1	Gene:	srebf2 / 100037309	ZFINID:	ZDB-GENE-070410-8	Length:	1099	Species:	Danio rerio

Alignment Length:	368	Identity:	84/368 - (22%)
Similarity:	131/368 - (35%)	Gaps:	113/368 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FGSSTSNTNTSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSF--ANGQQSLILTSDT 75
            |...|....|...|.:|.|:   |||.|... |.|......:.|   :||  ...|...|:||..
Zfish   119 FPMQTLAVQTQAQPQTVMIT---PTATPSRF-IQNQVICQQNNA---TSFQVLQPQMQSIMTSPQ 176

  Fly    76 GNPLMNSQGAQIFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNNLQLPTGCEIYL 140
            ..| |..|..:: ||..|       |...|:...|   ..:|::   :.|:|..:..|.
Zfish   177 VQP-MTIQHQRV-LTPAG-------QTIQTLSTAP---TTVHTM---SQQVPVLVHQPQ------ 220

  Fly   141 VKETGSLMGEPPTKAAIKLELDTLSEKP----LLPSVTTSSSTQSAVITAQTVNPPIPGNINTTT 201
            :.:|.||:               |:.||    :|.:|.:.:...:.....||....:|     |.
Zfish   221 ILKTDSLL---------------LTTKPDGTQVLSTVQSPTGITTLTTPIQTTALQMP-----TL 265

  Fly   202 STTSTTTTTSVLYG----------SHGNGHGHGHAHAQARSQPESAGQTPSSKLEAYKKRDDKRR 256
            .:::..||..|:.|          |.|..|..|.|.......|...   |...:     ::.:||
Zfish   266 MSSNILTTVPVVMGGGDKLPIKQLSSGPAHNIGGARVGVEQSPVVG---PGGVV-----KEGERR 322

  Fly   257 ATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSGR 321
            .|||.:|:|.|..||..|.:|::::                              .||.:..
Zfish   323 TTHNIIEKRYRSSINDKILELRDLV------------------------------LGNDAKM--- 354

  Fly   322 APPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQ 364
                 .||.:|.||.:|||.:|.....||   :|..:|:.:||
Zfish   355 -----HKSGVLRKAIDYIKYLQQVNHKLR---QENLTLKMANQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usf	NP_572167.3	HLH	255..343	CDD:278439	22/87 (25%)
srebf2	NP_001082935.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..47
		TFIIA	57..>221	CDD:281188	32/129 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..107
		HLH	321..371	CDD:278439	22/87 (25%)
		Leucine-zipper	370..391		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940