DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rb and AP3B1

DIOPT Version :9

Sequence 1:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster
Sequence 2:NP_003655.3 Gene:AP3B1 / 8546 HGNCID:566 Length:1094 Species:Homo sapiens


Alignment Length:1177 Identity:581/1177 - (49%)
Similarity:771/1177 - (65%) Gaps:115/1177 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64
            :||.|   .|.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
Human     2 SSNSF---PYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAM 63

  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
Human    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128

  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194
            ||||||||||||||||.:||||:||||::::|||||||||.|||||.||||||.:||:.|:.|||
Human   129 QLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193

  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259
            |||.|::|||.||.||||:||||:|:||||||||||||.|:||:|||||:||:|||||||||||.
Human   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258

  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324
            |..:.::|.::|       :.||:            |.||:|.|:....|               
Human   259 PWKEGDELEDNG-------KNFYE------------SDDDQKEKTDKKKK--------------- 289

  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389
             .|.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
Human   290 -PYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIV 353

  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
Human   354 LQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDK 418

  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519
            .|.|||||.|||||::|.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
Human   419 QFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHM 483

  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:||||.||||||.
Human   484 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNS 548

  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
Human   549 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NVKSGALSKYAKKIFLAQKPAPLLESPFK 612

  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714
            |.::||||:|||.||:.|.||.||..:|.:.||.||||:...   :|..|.:|:|.:|.::    
Human   613 DRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVI---ELAKEWTPAGKAKQEN---- 670

  Fly   715 GKEKGAGGEKGFLSE-------SDDKSSAYSESGSSSG-SGTSDSESDSDGSGSSDEEEEEVQKQ 771
                   ..|.|.||       ||..|.:.|||||.|| .|.|..|.||:...|.|...|:    
Human   671 -------SAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQ---- 724

  Fly   772 QPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSE---------DSSAYSGSS 827
                         |:.|...:...:  |.|...|:.|:|.|.:.|.|         |||....||
Human   725 -------------DSESGRESGLEN--KRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSS 774

  Fly   828 SDDSASGSDNEVK-KNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIG-PVMTP 890
            .:||:|.|::|.: ::|:::...||.::.|.|.::.|....|.     ||||||..|:. ||..|
Human   775 IEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVS-----LLDLDDFNPVSTPVALP 834

  Fly   891 SLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPH 954
                  ||. :|.:......|....:.:.:.:..|:.:..|...||:::||.||...|.|.|.|.
Human   835 ------TPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPC 893

  Fly   955 LYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019
            ::...|.||::...|..:::|..|.:|:..||.||:::.|.||..|:|:.:.:..:|:||.|||.
Human   894 IFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQ 958

  Fly  1020 AVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVAL 1084
            ....:|.:......:.::||||||:..|.:.|...::|:..|.||||....:....|:....| :
Human   959 TASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSV-I 1022

  Fly  1085 RQKVFESINVAHTHSSSSGQ--LHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVL 1147
            .|||   :|||:..:..|||  :|.||.:|:.|.||:|:|::.|......|::|.||.||||::|
Human  1023 FQKV---VNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLL 1084

  Fly  1148 NELRNAL 1154
            .||:..|
Human  1085 RELKPVL 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 386/580 (67%)
HEAT repeat 48..73 CDD:293787 19/24 (79%)
HEAT repeat 117..144 CDD:293787 26/26 (100%)
Cnd1 129..>252 CDD:289487 94/122 (77%)
HEAT repeat 147..179 CDD:293787 23/31 (74%)
HEAT repeat 188..214 CDD:293787 17/25 (68%)
AP3B1_C 881..1019 CDD:291462 41/139 (29%)
AP3B1NP_003655.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 8/31 (26%)
Adaptin_N 46..581 CDD:279882 381/569 (67%)
HEAT repeat 116..144 CDD:293787 27/27 (100%)
Cnd1 128..>251 CDD:289487 94/122 (77%)
HEAT repeat 150..180 CDD:293787 22/29 (76%)
HEAT repeat 188..213 CDD:293787 17/24 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..292 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..811 50/178 (28%)
SEEEED <729..>764 CDD:291463 8/36 (22%)
AP3B1_C 814..958 CDD:291462 48/154 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143298
Domainoid 1 1.000 760 1.000 Domainoid score I86
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68125
Inparanoid 1 1.050 1002 1.000 Inparanoid score I295
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54550
OrthoDB 1 1.010 - - D147356at33208
OrthoFinder 1 1.000 - - FOG0002006
OrthoInspector 1 1.000 - - otm41413
orthoMCL 1 0.900 - - OOG6_101595
Panther 1 1.100 - - LDO PTHR11134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2031
SonicParanoid 1 1.000 - - X1748
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

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