Protein Alignment rb and AP3B1

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 1177
• Identity: 581/1177 - (49%)
• Similarity: 771/1177 - (65%)
• Gaps: 115/1177 - (9%)

  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64
            :||.|   .|.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
Human     2 SSNSF---PYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAM 63

  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
Human    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128

  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194
            ||||||||||||||||.:||||:||||::::|||||||||.|||||.||||||.:||:.|:.|||
Human   129 QLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193

  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259
            |||.|::|||.||.||||:||||:|:||||||||||||.|:||:|||||:||:|||||||||||.
Human   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258

  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324
            |..:.::|.::|       :.||:            |.||:|.|:....|
Human   259 PWKEGDELEDNG-------KNFYE------------SDDDQKEKTDKKKK--------------- 289

  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389
             .|.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
Human   290 -PYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIV 353

  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
Human   354 LQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDK 418

  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519
            .|.|||||.|||||::|.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
Human   419 QFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHM 483

  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:||||.||||||.
Human   484 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNS 548

  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
Human   549 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NVKSGALSKYAKKIFLAQKPAPLLESPFK 612

  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714
            |.::||||:|||.||:.|.||.||..:|.:.||.||||:...   :|..|.:|:|.:|.::
Human   613 DRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVI---ELAKEWTPAGKAKQEN---- 670

  Fly   715 GKEKGAGGEKGFLSE-------SDDKSSAYSESGSSSG-SGTSDSESDSDGSGSSDEEEEEVQKQ 771
                   ..|.|.||       ||..|.:.|||||.|| .|.|..|.||:...|.|...|:
Human   671 -------SAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQ---- 724

  Fly   772 QPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSE---------DSSAYSGSS 827
                         |:.|...:...:  |.|...|:.|:|.|.:.|.|         |||....||
Human   725 -------------DSESGRESGLEN--KRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSS 774

  Fly   828 SDDSASGSDNEVK-KNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIG-PVMTP 890
            .:||:|.|::|.: ::|:::...||.::.|.|.::.|....|.     ||||||..|:. ||..|
Human   775 IEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVS-----LLDLDDFNPVSTPVALP 834

  Fly   891 SLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPH 954
                  ||. :|.:......|....:.:.:.:..|:.:..|...||:::||.||...|.|.|.|.
Human   835 ------TPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPC 893

  Fly   955 LYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019
            ::...|.||::...|..:::|..|.:|:..||.||:::.|.||..|:|:.:.:..:|:||.|||.
Human   894 IFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQ 958

  Fly  1020 AVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVAL 1084
            ....:|.:......:.::||||||:..|.:.|...::|:..|.||||....:....|:....| :
Human   959 TASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSV-I 1022

  Fly  1085 RQKVFESINVAHTHSSSSGQ--LHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVL 1147
            .|||   :|||:..:..|||  :|.||.:|:.|.||:|:|::.|......|::|.||.||||::|
Human  1023 FQKV---VNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLL 1084

  Fly  1148 NELRNAL 1154
            .||:..|
Human  1085 RELKPVL 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	386/580 (67%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	26/26 (100%)
		HEAT repeat	147..179	CDD:293787	23/31 (74%)
		HEAT repeat	188..214	CDD:293787	17/25 (68%)
		AP3B1_C	881..1019	CDD:464319	41/139 (29%)
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		8/31 (26%)
		Adaptin_N	46..581	CDD:396262	381/569 (67%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		HEAT repeat	150..180	CDD:293787	22/29 (76%)
		HEAT repeat	188..213	CDD:293787	17/24 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		9/58 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		50/178 (28%)
		SEEEED	<731..>764	CDD:434218	8/34 (24%)
		AP3B1_C	813..958	CDD:464319	48/155 (31%)