DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and APL2

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_012787.1	Gene:	APL2 / 853723	SGDID:	S000001618	Length:	726	Species:	Saccharomyces cerevisiae

Alignment Length:	811	Identity:	188/811 - (23%)
Similarity:	332/811 - (40%)	Gaps:	157/811 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :|:..|.|.....:.:|:|:.|..:..|:|.|.|||.|:||:.:.::|.|||||:|::.|||...
Yeast    30 ELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNYAETHP 94

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            :|.:|:::||....:|||.|||..|:|.:|.|||..|:..:...:|.:..|.:.||||||...:.
Yeast    95 ELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTAVICVA 159

  Fly   177 KLYSLDADQKDELVMVIEKL---LSDRTTLVVGSAVMAFDEV---CPERVDLIHKNYRKLCNFLL 235
            ||:.|:.|...|| .|:|.|   |.|...||:.:|..|..|:   ..:.|||.......:..|||
Yeast   160 KLFQLNKDLCVEL-GVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVSQFLL 223

  Fly   236 ---DVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSS 297
               :..||.::||:..|:.|:              ..|.|....:.:|.       ::|
Yeast   224 ALNECTEWARIIILGTLSEYS--------------AKDSLEAQDIIDRV-------TAH------ 261

  Fly   298 DDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHV 362
                                                          ||..|.:||:|..::....
Yeast   262 ----------------------------------------------LQHVNPAVVLATIKVIVRN 280

  Fly   363 APKNE-------VQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTH 420
            .|:.|       ::.::.|.:.|:.:..|:|.|.|..|..:..|...:....|:.|:|:.:||.:
Yeast   281 LPQIEYSSNSLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLY 345

  Fly   421 IKLLKLDILTNLASAGSI---SLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSG- 481
            :||.|:|||..|....::   :|:|.|.:.|....:..||:..|||:.:.  .||...|:.:|.
Yeast   346 VKLEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQL--GIKYAQESFVSKV 408

  Fly   482 ---LVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLI-----------DYINVPAAR 532
               |:.||...|. :..:..:.:..||:     |.....:|||.:           ..:....|:
Yeast   409 LDILLELLERQDT-IKDDCCISLCDLLR-----HCPGNDKMAKQVCAVFNTWSNPEVLLQSDIAK 467

  Fly   533 AAIIWLIGEYNEKVPLIAPDVLRKM---AKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYV 594
            ...:||:|::    |....|:..|:   .::||.|:.:.::.:|...|:|:.|   .|..:.|.|
Yeast   468 CNYVWLLGQH----PNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRLHAT---LTGSMLQSV 525

  Fly   595 FTLARYDPN-YDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGS 658
            ..||....: .||||.|....:.:...:..|.|......::.:.|........:..:....:||:
Yeast   526 LELATQQTHELDVRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGT 590

  Fly   659 LSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGE 723
            :|..               ...|||:.|....::|:.:.|:......|..|:      |..:...
Yeast   591 ISSI---------------YFKPDSNRRKGKKYVQNIVKGKHIEELESMAKN------EISSKAN 634

  Fly   724 KGFLSESDDKSSAYSESGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGS 788
            ...|.:.|::....:.:.....:.|:..:.|........|:..::.......|..:||..:...|
Yeast   635 DDVLLDFDERDDVTNTNAGMLNTLTTLGDLDDLFDFGPSEDATQINTNDTKAVQGLKELKLGGDS 699

  Fly   789 NELAATSSPVKATINNNNNARGSSGTSDSED 819
            |.:::         ...||...|.|...|:|
Yeast   700 NGISS---------GGKNNPDVSGGNIVSQD 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	157/611 (26%)
		HEAT repeat	48..73	CDD:293787	6/24 (25%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	46/131 (35%)
		HEAT repeat	147..179	CDD:293787	10/31 (32%)
		HEAT repeat	188..214	CDD:293787	11/28 (39%)
		AP3B1_C	881..1019	CDD:291462
APL2	NP_012787.1	COG5096	6..726	CDD:227427	188/811 (23%)
		HEAT repeat	64..88	CDD:293787	12/23 (52%)
		HEAT repeat	100..127	CDD:293787	11/26 (42%)
		HEAT repeat	134..164	CDD:293787	10/29 (34%)
		HEAT repeat	173..199	CDD:293787	9/25 (36%)
		HEAT repeat	214..242	CDD:293787	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910