Protein Alignment rb and APL6

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_011777.3
• Gene: APL6 / 853177
• SGDID: S000003493
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 872
• Identity: 221/872 - (25%)
• Similarity: 391/872 - (44%)
• Gaps: 176/872 - (20%)

  Fly    38 FQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDL---FPAVVKNVVSKNIEVKKLV 99
            :.|.......|..:|:|.......:||||||.::|...|:.|:   |..||||:.:.:.:||:|:
Yeast    37 YYSQNINPQQLVTLLNSRNSREVRDAMKRIISIMASDDDSIDVQLYFADVVKNITTNDTKVKRLI 101

  Fly   100 YVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLS 164
            ::||:|:||...:|.||||::.|::|.|.|..:|..||..||.:::|.:.||::..::....|.|
Yeast   102 HLYLLRFAENDPNLTLLSINSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILHTVKKLVTDPS 166

  Fly   165 PYVRKTAAHAIPKLYSLDA-DQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYR 228
            ..||...|.||.|||.... |..:||:.::::|::|....|:..||:|:.|...:.::|:|.::|
Yeast   167 AMVRGEVALAIIKLYRAGKNDYHEELLDILKELMADTDPKVISCAVLAYKECYADHLELLHGHFR 231

  Fly   229 KLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGET-PVSERFYDESSHSSSHS 292
            :.|..:..:|.|.|..:|.:|.:|.:.....|...|:.  ::|...: |:.:: |:|..:
Yeast   232 RYCRIIKQLDSWSQSYLIELLIKYCKQYLPKPTVVDKS--SEGSPRSCPLPDK-YNEIEY----- 288

  Fly   293 DDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQ 357
                                          ||.....|.|..|.|:....|:.|.|.:|:::...
Yeast   289 ------------------------------PSYEVVNDPDLDLFLQSLNCLIYSSNPTVILSCCN 323

  Fly   358 -LYHHVAP---KNEVQLIAKALIRLL-----RSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFV 413
             ||...:|   ||  ....:||:|.:     :.:||   ::|..|..:|...:.:|.|:.|.|:|
Yeast   324 ALYQLASPLQMKN--TKFIEALVRTVTMTENQGNKE---MLLQAIHFLSILDQTLFLPYTKKFYV 383

  Fly   414 RTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSS--DRSFVAATIQAIGRCASSIKEVTE 476
            ...||....:.|:.||:.|.:..::..|.:|.:.|::|:  ..:.|...::::.||.    :::.
Yeast   384 FPKDPIVASIWKIQILSTLINESNVKEIFKELKYYVASAHFPENVVIMAVKSLSRCG----QLST 444

  Fly   477 TCLSGLVHLLSNH-DEHVVAESVV-----VIKRLLQTKAAEHFEIITQMAKLIDYINVPA--ARA 533
            :..|.::..|.:| :.|.::.||:     ||:.|:|....:|..||.::|.|:......|  |||
Yeast   445 SWESHVMKWLIDHMESHNLSASVLDAYVNVIRMLVQKNPTKHLRIIFKLADLLTVQTSLADNARA 509

  Fly   534 AIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKL-----------YLTNPEQT 587
            .|:||.||.......|.|||||::.::|.:|....:.|:|.|..||           .:|..|:.
Yeast   510 GIVWLFGEIASIEFKICPDVLRRLIQNFSNEGPETRCQILVLSAKLLSYDIDNFKQAQVTGSEEN 574

  Fly   588 --------------SLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLAS 638
                          |.:...|..||:||..:|:|||||.:..:.  .||...::|      .|..
Yeast   575 NQNPPYYDFSGSRISQMYNAVLYLAKYDDEFDIRDRARMISSLF--DSGKYEIVS------LLLQ 631

  Fly   639 KPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPS 703
            .|.|...|     ::|   .:|..|.......||.  |.::|.::.:..:..      .|.|.
Yeast   632 APKPTARS-----DDF---IVSARLETHTPEIKEF--FRMLPWNTEITEVGE------TGNDI-- 678

  Fly   704 GHSKDKSGREGGKEKGAGG-EKGFLSES---DDKSSAYSESGSSSGSGTSDSESDS-DGSG---- 759
                    |||.:.|.... :|.|.|:|   ::.:.:::.|.::..:|.:|.:|:| .|.|
Yeast   679 --------REGAELKDYNKYKKSFSSQSFITNNSARSFTSSSNAKLTGINDGDSNSISGKGNVNT 735

  Fly   760 ------------SSDEEEEEV--QKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARG 810
                        |.||...::  :|.:|.|:..|.|...|...:|
Yeast   736 FTSQNGKKYRLQSLDEFFSDIPERKSKPRKIIKVVEESSDEDEDE-------------------- 780

  Fly   811 SSGTSDSEDSSAYSGSSSDDSASGSDN 837
               :.:|.|...||.||...|:||:.:
Yeast   781 ---SEESSDDDEYSDSSLGTSSSGTSS 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	171/629 (27%)
		HEAT repeat	48..73	CDD:293787	9/24 (38%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		HEAT repeat	147..179	CDD:293787	10/31 (32%)
		HEAT repeat	188..214	CDD:293787	8/25 (32%)
		AP3B1_C	881..1019	CDD:464319
APL6	NP_011777.3	COG5096	6..770	CDD:227427	208/813 (26%)
		HEAT repeat	45..69	CDD:293787	9/23 (39%)
		HEAT repeat	119..146	CDD:293787	11/26 (42%)
		HEAT repeat	153..182	CDD:293787	10/28 (36%)