DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and AT4G23460

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_194077.1	Gene:	AT4G23460 / 828445	AraportID:	AT4G23460	Length:	893	Species:	Arabidopsis thaliana

Alignment Length:	919	Identity:	244/919 - (26%)
Similarity:	389/919 - (42%)	Gaps:	203/919 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||:.|:|.....:.:|:|::|..:..|:|.|.||..||..:.::|:|:|||||:||:.||:.|.
plant    19 ELKEELNSQYKDKRKDAVKKVIAAMTVGKDVSSLFTDVVNCMQTENLELKKLVYLYLINYAKSQP 83

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |||:|:::||.:..:|||.||||.|:|.:..|||..|...:...::....|..||||||||..:.
plant    84 DLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKITEYLCDPLQKCLKDDDPYVRKTAAICVA 148

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHK----NYRKLCNFLL 235
            ||:.::|:..::  .:..::.|:||...:||.:||.|..|:.......|.:    ...||...|.
plant   149 KLFDINAELVEDRGFLEALKDLISDNNPMVVANAVAALAEIQENSTSPIFEINSTILTKLLTALN 213

  Fly   236 DVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDE 300
            :..|||||.|::.|:||.                                          :||
plant   214 ECTEWGQVFILDALSRYK------------------------------------------ASD-- 234

  Fly   301 KNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVM-AVAQLYHHV-- 362
                               |....|          ::.:..|.||..|.:||: ||..:...:
plant   235 -------------------PREAEN----------IVERVTPRLQHANCAVVLSAVKMILQQMEL 270

  Fly   363 -----APKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIK 422
                 ..:|..:.:|..|:.||.:..|:|.|.|..|..:..||..|....:|.||.:.:||.::|
plant   271 ITSTDVIRNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQKRPTILAHEIKVFFCKYNDPIYVK 335

  Fly   423 LLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLS 487
            :.||:|:..|||..:|..:|.||:.|.:..|..||...::||||||..::...|.|:|.|:.|:.
plant   336 MEKLEIMIKLASDRNIDQVLLEFKEYATEVDVDFVRKAVRAIGRCAIKLERAAERCISVLLELIK 400

  Fly   488 NHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPD 552
            ....:||.|:::|||.:.:.....:..||..:.:.:|.::.|.|:|::||:||||.|::. .|.:
plant   401 IKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESLDTLDEPEAKASMIWIIGEYAERID-NADE 464

  Fly   553 VLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP-EQTSLLCQYVFTLARYD-PNYDVRDRARFLRQ 615
            :|....::|.:|...|:||:|...|||:|..| |....:.|.|...|..: .|.|:||||....:
plant   465 LLESFLENFPEEPAQVQLQLLTATVKLFLKKPTEGPQQMIQVVLNNATVETDNPDLRDRAYIYWR 529

  Fly   616 IIFPASGTSSVLSQHARQVFLASKPAPVPESKYRD--------GNNFQLGSLSH----------- 661
            ::       |...:.|:.|.||.||....:|...|        .|...|.|:.|
plant   530 LL-------STDPEAAKDVVLAEKPVITDDSNQLDPSLLDELLANISTLSSVYHKPPEAFVTRLK 587

  Fly   662 ----------YLNMPAAGYKE---------------------LPAFPVIPPDSSVRNIAGFMQDK 695
                      |:.....||.|                     |.|.|...||         :...
plant   588 TTVQKTEDEDYVEGSETGYPEASGNPVDGAASPSATTGYVTKLAAAPAPVPD---------LLGD 643

  Fly   696 LPGEDSPSGHSKDKSGREGGK--------EKGAGGEKGFLSESDDKSSAYS---ESGSSSGSGTS 749
            |.|.|:.:....|:.....|:        .||.|.:........|....||   |:.|.|.....
plant   644 LMGSDNAAIVPVDEPTTPSGRPLPVVLPASKGQGLQISAQLTRQDGQVFYSMLLENNSQSLLDGF 708

  Fly   750 DSESDSDGSGSSDEEEEEVQKQQP-----TKVSSVKERLIDAGSNELAATSSPVKATINNNNNAR 809
            ..:.:.:..|.:.....:|...||     |.:..|..:.:..||     |||.::..:.||...
plant   709 MIQFNKNSFGLAAVGSLQVPPLQPGASARTMMPMVLSQNMSTGS-----TSSVLQVAVKNNQQP- 767

  Fly   810 GSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPE---KLKEKHEKQPE-----QT 866
                ....||....:...|:|.             :.:.||..|   .|.:.:|.|.|     .|
plant   768 ----VWYFEDKIVLNALFSEDG-------------RMERGTFLETWKSLPDSNEVQKEFPGITIT 815

  Fly   867 AVKSNLDLL 875
            :|:|.||||
plant   816 SVESTLDLL 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	177/589 (30%)
		HEAT repeat	48..73	CDD:293787	7/24 (29%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	43/128 (34%)
		HEAT repeat	147..179	CDD:293787	11/31 (35%)
		HEAT repeat	188..214	CDD:293787	8/27 (30%)
		AP3B1_C	881..1019	CDD:291462
AT4G23460	NP_194077.1	Adaptin_N	13..535	CDD:396262	178/596 (30%)
		HEAT repeat	56..77	CDD:293787	11/20 (55%)
		HEAT repeat	89..116	CDD:293787	11/26 (42%)
		HEAT repeat	123..153	CDD:293787	11/29 (38%)
		HEAT repeat	162..188	CDD:293787	8/25 (32%)
		HEAT repeat	201..229	CDD:293787	10/27 (37%)
		Alpha_adaptinC2	672..771	CDD:197886	22/108 (20%)
		B2-adapt-app_C	781..892	CDD:198088	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920