DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and AT4G11380

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_001190701.1	Gene:	AT4G11380 / 826741	AraportID:	AT4G11380	Length:	916	Species:	Arabidopsis thaliana

Alignment Length:	987	Identity:	248/987 - (25%)
Similarity:	403/987 - (40%)	Gaps:	219/987 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQD 112
            :|..||..||     |:|::|..:..|:|.|.||..||..:.::|:|:|||||:||:.||:.|.|
plant    47 VKLRLDKRKD-----AVKKVIAAMTVGKDVSSLFTDVVNCMQTENLELKKLVYLYLINYAKSQPD 106

  Fly   113 LALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPK 177
            ||:|:::||.:..:|||.||||.|:|.:..|||..|...:...::....|..||||||||..:.|
plant   107 LAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKITEYLCDPLQKCLKDDDPYVRKTAAICVAK 171

  Fly   178 LYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHK----NYRKLCNFLLD 236
            |:.::|:..::  .:..::.|:||...:||.:||.|..|:.......|.:    ...||...|.:
plant   172 LFDINAELVEDRGFLEALKDLISDNNPMVVANAVAALAEIQENSSSPIFEINSTTLTKLLTALNE 236

  Fly   237 VDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEK 301
            ..|||||.|::.|::|..       ||..:..|
plant   237 CTEWGQVFILDALSKYKA-------ADPREAEN-------------------------------- 262

  Fly   302 NKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVM-AVAQLYHHV--- 362
                                              ::.:..|.||..|.:||: ||..:...:
plant   263 ----------------------------------IVERVTPRLQHANCAVVLSAVKMILQQMELI 293

  Fly   363 ----APKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKL 423
                ..:|..:.:|..|:.||.:..|:|.|.|..|..:..||..|....:|.||.:.:||.::|:
plant   294 TSTDVIRNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQKRPTILAHEIKVFFCKYNDPIYVKM 358

  Fly   424 LKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSN 488
            .||:|:..|||..:|..:|.||:.|.:..|..||...::||||||..::...|.|:|.|:.|:..
plant   359 EKLEIMIKLASDRNIDQVLLEFKEYATEVDVDFVRKAVRAIGRCAIKLERAAERCISVLLELIKI 423

  Fly   489 HDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDV 553
            ...:||.|:::|||.:.:.....:..||..:.:.:|.::.|.|:|::||:||||.|::. .|.::
plant   424 KVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESLDTLDEPEAKASMIWIIGEYAERID-NADEL 487

  Fly   554 LRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP-EQTSLLCQYVFTLARYD-PNYDVRDRARFLRQI 616
            |....::|.:|...|:||:|...|||:|..| |....:.|.|...|..: .|.|:||||....::
plant   488 LESFLENFPEEPAQVQLQLLTATVKLFLKKPTEGPQQMIQVVLNNATVETDNPDLRDRAYIYWRL 552

  Fly   617 IFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPP 681
            :       |...:.|:.|.||.||....:|...|.:  .|..|...::..::.|.:       ||
plant   553 L-------STDPEAAKDVVLAEKPVISDDSNQLDPS--LLDELLTNISTLSSVYHK-------PP 601

  Fly   682 DSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESGSSSGS 746
            ::.|..:...:| |...||...|                                 ||:|.||.:
plant   602 EAFVTRLKTTVQ-KTEDEDFAEG---------------------------------SEAGYSSSN 632

  Fly   747 GTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAA--------TSS----PVK 799
            ..     ||..|...:..:...::..|...:.|.:.|.|....:.||        |.|    ||.
plant   633 PV-----DSAASPPGNIPQPSGRQPAPAVPAPVPDLLGDLMGLDNAAIVPVDDPITQSGPPLPVV 692

  Fly   800 ATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPE 864
            ...::....:.|:..|..:....||....::|.|..|.                 ...:..|...
plant   693 VPASSGQGLQISAQLSRKDGQVFYSMLFENNSQSVLDG-----------------FMIQFNKNTF 740

  Fly   865 QTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEF 929
            ..|...:|       .|||:.|                 |..|..:.|......:....||.:
plant   741 GLAAAGSL-------QIPPLHP-----------------ATSARTMLPMVLFQNMSAGPPSSL-- 779

  Fly   930 KHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQ-LNE 993
                         |.:|.:..:.|..|.:....:...|...|..|.........:||...: |.|
plant   780 -------------LQVAVKNNQQPVWYFTDKIILHALFGEDGRMERGTFLETWRSLPDSNEVLKE 831

  Fly   994 FAPITVLQPQQT 1005
            |..||:...:.|
plant   832 FPGITITSVEST 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	176/588 (30%)
		HEAT repeat	48..73	CDD:293787	8/24 (33%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	43/128 (34%)
		HEAT repeat	147..179	CDD:293787	11/31 (35%)
		HEAT repeat	188..214	CDD:293787	8/27 (30%)
		AP3B1_C	881..1019	CDD:291462	24/126 (19%)
AT4G11380	NP_001190701.1	Adaptin_N	46..557	CDD:279882	177/595 (30%)
		HEAT repeat	78..99	CDD:293787	11/20 (55%)
		HEAT repeat	111..138	CDD:293787	11/26 (42%)
		Cnd1	123..291	CDD:289487	55/240 (23%)
		HEAT repeat	145..175	CDD:293787	11/29 (38%)
		Alpha_adaptinC2	695..794	CDD:197886	22/154 (14%)
		B2-adapt-app_C	804..915	CDD:198088	11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920