DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rb and AP3B2

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_001265441.1	Gene:	AP3B2 / 8120	HGNCID:	567	Length:	1101	Species:	Homo sapiens

Alignment Length:	1181	Identity:	602/1181 - (50%)
Similarity:	761/1181 - (64%)	Gaps:	154/1181 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EFGADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVS 90
            |:|.||||| ..|.||.::|||||:|||:|||.|||||||||:.|||||::||||||||||||..
Human    21 EYGHDPASG-GIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVAC 84

  Fly    91 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLA 155
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||.:||||:|||
Human    85 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLA 149

  Fly   156 IRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERV 220
            |:::|:|:|||||||||||||||||||:||||:|:.||||||:|:||||.||.||||:||||||:
Human   150 IKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERI 214

  Fly   221 DLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDES 285
            ||||||||||||.|:||:|||||:||:||||||||||:.|..      |:.|.|....:.||
Human   215 DLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQ------NESLLEENAEKAFY--- 270

  Fly   286 SHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNS-YHIDVDHRLLLRQTKPLLQSRNA 349
                     ||.:||        ....|...:...::||.. |.:|.|||||||.||||||||:|
Human   271 ---------GSEEDE--------AKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSA 318

  Fly   350 SVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVR 414
            :|||||||||.|:|||.||.:|||||:||||||.|||.|||..:|:||.||:.:|||:||||::|
Human   319 AVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIR 383

  Fly   415 TSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCL 479
            ::|||.||:|||::|||||:..:|..:||||||||.|.|:.|||||||||||||::|..|.:|||
Human   384 STDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCL 448

  Fly   480 SGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNE 544
            :|||.||||.||.||||||||||:|||.:.|:|.|||..:|||.|.|.||.|||:|:||||||.|
Human   449 NGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513

  Fly   545 KVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDR 609
            .||.|||||||||||||..|:|:|||||:||..||||||.:||.||.|||.:||:||.|||:|||
Human   514 HVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDR 578

  Fly   610 ARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674
            |||.||:|.| |.....||:||:::|||.|||||.||.::|.::||||||||.||..|.||:|||
Human   579 ARFTRQLIVP-SEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELP 642

  Fly   675 AFPVIPPDSSVRNI-----------AGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLS 728
            .:|...||.||||:           .|.:     ||.:........|.||..|||    ||.|.|
Human   643 DWPEEAPDPSVRNVEEEDLSLIETHVGLL-----GEYTEVPEWTKCSNREKRKEK----EKPFYS 698

  Fly   729 ES--------------DDKSSAYSESGSSSGSGTSDSESDSD--------GSGSSDEEEEEVQKQ 771
            :|              :.:|.:.|:|.|.||||.|.||||::        |.||..|:.||..|:
Human   699 DSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKR 763

  Fly   772 QPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSD 836
            :..|  .|.||                             .|.:.|.|..:.|.|||.:|...|:
Human   764 KTKK--KVPER-----------------------------KGEASSSDEGSDSSSSSSESEMTSE 797

  Fly   837 NEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDDI--PPIGPVMTPSL------ 892
            :|.::.|..:.:...|          |...:..:..:: ||||:|.  |.:.||..|::
Human   798 SEEEQLEPASWSRKTP----------PSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLA 852

  Fly   893 ----GGFLTPGT--PMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTR 951
                |..||..|  |.:      |.|      |..||       .:|||::|:|.||.:.|.|:|
Human   853 ADLEGLTLTDSTLVPSL------LSP------VSGVG-------RQELLHRVAGEGLAVDYTFSR 898

  Fly   952 SPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFND 1016
            .|......|.|:.:.|.|..:..|..:.:|...||||:.:.||..|..|.|.::|:.|:|::|.|
Human   899 QPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCD 963

  Fly  1017 STHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELR---GLRQDL 1078
            ||.|.:.:|.:......:.::||||||:..|.:.|:..::|:.||.||||...:|.   ..|.|.
Human   964 STQAANFQLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDH 1028

  Fly  1079 IDVVALRQKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIG 1143
            |.|    |||..:.|:......:|.: :.|||:||:..||||||||.:...|..|.||.||||||
Human  1029 IVV----QKVTATANLGRVPCGTSDE-YRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIG 1088

  Fly  1144 SMVLNELRNAL 1154
            :|::.::..||
Human  1089 TMLVKDVIQAL 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	399/581 (69%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	25/26 (96%)
		Cnd1	129..>252	CDD:289487	99/122 (81%)
		HEAT repeat	147..179	CDD:293787	24/31 (77%)
		HEAT repeat	188..214	CDD:293787	18/25 (72%)
		AP3B1_C	881..1019	CDD:291462	46/151 (30%)
AP3B2	NP_001265441.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/9 (78%)
		Adaptin_N	34..590	CDD:279882	399/582 (69%)
		HEAT repeat	111..139	CDD:293787	26/27 (96%)
		Cnd1	123..267	CDD:289487	110/149 (74%)
		HEAT repeat	145..173	CDD:293787	21/27 (78%)
		HEAT repeat	182..208	CDD:293787	18/25 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..295		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..821		47/180 (26%)
		AP3B1_C	823..966	CDD:291462	51/161 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143297
Domainoid	1	1.000	760	1.000	Domainoid score	I86
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I295
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54550
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	1	1.000	-	-		otm41413
orthoMCL	1	0.900	-	-		OOG6_101595
Panther	1	1.100	-	-	O	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2031
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940