DRSC/TRiP Functional Genomics Resources

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Protein Alignment rb and Ap4b1

DIOPT Version :9

Sequence 1:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster
Sequence 2:NP_001157024.1 Gene:Ap4b1 / 67489 MGIID:1337130 Length:738 Species:Mus musculus


Alignment Length:704 Identity:173/704 - (24%)
Similarity:289/704 - (41%) Gaps:175/704 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 MKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDP 128
            ::|:|..:.:|.|.||:|..:||...:.:|..|||||:|:..||..:.|||||:|:|..:...||
Mouse    33 IQRVIRHMTQGLDMSDVFMEMVKASATVDIVQKKLVYLYMGTYAPLKPDLALLAINTLCKDCSDP 97

  Fly   129 NQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDE--LVM 191
            |.::|..|||.:.|:|:..:...:...:.:...|.:.|||:.|.....|:::|..|.:.:  ||.
Mouse    98 NPMVRGLALRSMCSLRMPGVQEYIQQPVVNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVN 162

  Fly   192 VIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKN--YRKLCNFLLDVDEWGQVIIINMLTRYAR 254
            .:..||.|:..:||.:.:.:.:|:..:...::...  ...|.|.:..:|:|||..::|.|.||  
Mouse   163 ELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRY-- 225

  Fly   255 TQFVDPNADDE--DLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGS 317
                .|.:::|  |::|                                                
Mouse   226 ----QPRSEEELFDILN------------------------------------------------ 238

  Fly   318 RTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPK-NEVQLIAKALIR---- 377
                 ..:||                |:|.:..|||...:|:..:|.| ..||  ...|:|    
Mouse   239 -----LLDSY----------------LKSSSTGVVMGATKLFLILAKKFPHVQ--TDVLVRVKGP 280

  Fly   378 -LLRSHKEVQSVVLNCIASMSTKRKAI------FEPHLKSFFVRTSDPTHIKLLKLDILTNLASA 435
             |.....|.:.:   |.|::...|:.:      |..|.|.||...|:|.:|||.|:::|..|.:.
Mouse   281 LLAACSSESREL---CFAALCHVRQVLHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVND 342

  Fly   436 GSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVV 500
            .::..:|.|.:.|.:.....|..|.|.|||..|   |..|:.|:..|..||....||:   :.||
Mouse   343 ENVQQVLEELRGYCTDVAADFAQAAIFAIGSIA---KTYTDQCVQILTELLGLRQEHI---TTVV 401

  Fly   501 IK--RLLQTKAAEHFEIITQ-MAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFV 562
            ::  |.|.....:..|.:.| :....:.|.....:.|:|||:|.:.||:| .||.||    :.||
Mouse   402 VQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGEKIP-NAPYVL----EDFV 461

  Fly   563 DEQ-----DVVKLQVLNLGVKLYLTNPEQTSLLCQYVF-TLARY----DPNYDVRDRARFLRQII 617
            |..     ..||:::|...::|.|:.|.:    ||.:. .|..|    :.:..||||..|..:::
Mouse   462 DNVKSETFPAVKMELLTALMRLVLSRPAE----CQDMLGRLLHYCIEEEKDMAVRDRGLFYYRLL 522

  Fly   618 FPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPD 682
            .  .|...|     :|:..:.|..|            .||.|           ::.|..||....
Mouse   523 L--VGIDKV-----KQILCSPKSDP------------SLGLL-----------EDQPERPVNSWA 557

  Fly   683 SSVRNIAGFM-----------------QDKLPGEDS--PSGHSKDKSGREGGKE 717
            |....:|...                 :.:||...|  .|||...:..:||.:|
Mouse   558 SDFNTLAPVYGRAHWATISKCQQVERHRLELPHNASFATSGHLISEENKEGAQE 611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 151/587 (26%)
HEAT repeat 48..73 CDD:293787 2/8 (25%)
HEAT repeat 117..144 CDD:293787 10/26 (38%)
Cnd1 129..>252 CDD:289487 31/126 (25%)
HEAT repeat 147..179 CDD:293787 6/31 (19%)
HEAT repeat 188..214 CDD:293787 7/27 (26%)
AP3B1_C 881..1019 CDD:291462
Ap4b1NP_001157024.1 Adaptin_N 9..525 CDD:396262 151/588 (26%)
HEAT repeat 86..113 CDD:293787 10/26 (38%)
HEAT repeat 120..150 CDD:293787 6/29 (21%)
HEAT repeat 159..185 CDD:293787 7/25 (28%)
HEAT repeat 198..222 CDD:293787 7/23 (30%)
Hinge. /evidence=ECO:0000250|UniProtKB:Q9Y6B7 534..600 15/88 (17%)
Ear, mediates interaction with TEPSIN. /evidence=ECO:0000250|UniProtKB:Q9Y6B7 601..738 3/11 (27%)
B2-adapt-app_C 620..729 CDD:401126
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833474
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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