DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rb and ap3b1a

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	XP_021324676.1	Gene:	ap3b1a / 563316	ZFINID:	ZDB-GENE-031112-8	Length:	1111	Species:	Danio rerio

Alignment Length:	1186	Identity:	590/1186 - (49%)
Similarity:	769/1186 - (64%)	Gaps:	115/1186 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQQNSASNPFAMSTYVERPQMGLDVEFGADPA----------SG--AAF--FQSDGRKHDDLKQM 51
            |..||.|       |.::   |..||.|.|.|          ||  |||  |.:|.:|::|||:|
Zfish     4 MSANSVS-------YNDQ---GSSVESGVDAAQENSNIQASISGGAAAFSLFSADYKKNEDLKEM 58

  Fly    52 LDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALL 116
            |:|||:.||||||||::|:||.|::||:|||||||||.|||||:|||||||||||||||||||||
Zfish    59 LESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALL 123

  Fly   117 SISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSL 181
            |||||||||||||||||||||||||||||.:||||:||||:::|.||||||||||||||.|||||
Zfish   124 SISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSL 188

  Fly   182 DADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIII 246
            |.|||:.|:.||||||.|::|||.||.||||:||||:|:||||||||||||.|:||:|||||:||
Zfish   189 DPDQKEHLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVII 253

  Fly   247 NMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNN 311
            :||||||||||:.|..:|               ..:||:|..:.:    .|::|:....
Zfish   254 HMLTRYARTQFISPWRED---------------AIFDENSEKTFY----DSEEERRVDQ------ 293

  Fly   312 GGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALI 376
                        |..|.:|.|||||||.|||||||||.:|||||.|||.|:|||:|:.:|.|:|:
Zfish   294 ------------SKPYIMDPDHRLLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHEISIITKSLV 346

  Fly   377 RLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLI 441
            ||||||:|||.|||..||:||.:||.:|||.:|||:||::|.||||.|||:||||||:..:||.|
Zfish   347 RLLRSHREVQYVVLQNIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTI 411

  Fly   442 LREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQ 506
            |||||||:.|.|::|.|||||||||||::|.|||:|||:|||.||||.||.||||||||||:|||
Zfish   412 LREFQTYVKSQDKAFAAATIQAIGRCATNISEVTDTCLNGLVLLLSNRDETVVAESVVVIKKLLQ 476

  Fly   507 TKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQ 571
            |:.::|.:||..||||.|.|.||.|||:|:||:|||.|.||.|||||||||||||..|:|:||||
Zfish   477 TQPSQHSDIIKHMAKLFDNITVPMARASILWLMGEYCEHVPKIAPDVLRKMAKSFTSEEDIVKLQ 541

  Fly   572 VLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFL 636
            .:||..||||||.:||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::||::.:
Zfish   542 TVNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NEKSGALSKYARRILM 605

  Fly   637 ASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGE-- 699
            |.|||||.:|.::|.:.:|||:|||.||..|.||.||..:|...||.||||:......|..|.
Zfish   606 APKPAPVLQSAFKDRDRYQLGTLSHTLNSQATGYLELSDWPAAAPDQSVRNVEVVEPVKESGAPS 670

  Fly   700 --DSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESG-------------SSSGSGTS 749
              .|.:|.||:|...:..:|:....|:....:|...||..||||             |||.|..|
Zfish   671 LGKSKAGKSKEKFYSDEEEEEEEEDEESNSEDSSSSSSEESESGSESEENSEVSNKSSSSQSEKS 735

  Fly   750 DSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGT 814
            .|||||| .....::.:::|:|:|.. .:.|::..:||.:|..:.|          .:..|||.:
Zfish   736 SSESDSD-KKKKTQKNKKIQQQKPDS-KNRKQKNGNAGKSESRSES----------ESGSGSSSS 788

  Fly   815 SDSEDSSAYSGSS-SDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDL 878
            ..|.||.:.|||. ..||.||:|.  |||     |.:||.:.|.. .||.|:..|.     ||||
Zfish   789 ESSSDSGSESGSELESDSDSGTDQ--KKN-----TKSKPVQSKPV-VKQVEKKEVS-----LLDL 840

  Fly   879 DDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGL 943
            ||..|. ||.||. ...|:|.. :...|...:.|..|   ::...|..:.....|||::::|.||
Zfish   841 DDFAPT-PVTTPK-SSILSPSL-LSDLQGLSISPTSA---LQASSPVFVPETSYELLHRMTGKGL 899

  Fly   944 HLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASG 1008
            ...|||||.|.:|.|||.|::|...|..|:.:..|.:.|.:..| ..::.|..:..|:||.:.:.
Zfish   900 SGQYRFTRQPCIYDSSMVSLQLTLSNSSEQPLENIHISQKSSSA-QNIHCFNAVERLEPQASVTV 963

  Fly  1009 VLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRG 1073
            .:||:|||||.|.:.:|.:......:.::|.||||:..|.:.|:....|:.||.||||....:.
Zfish   964 SIGVNFNDSTQAANFQLCTKEDEFSVSIQPAVGELLLPVSMSEADFTREQGKLLGMNESSATIT- 1027

  Fly  1074 LRQDLIDVVALRQKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCE 1138
            :..:.|...::.:||....|:. ..||:...:|.|||:|:||.||||:::..|..|| .:.||.|
Zfish  1028 MSPENISSQSVSRKVVSVANLG-VISSTQENIHRFAGKTVSSSSLVLVSVTLKDPDA-QITVNTE 1090

  Fly  1139 KMVIGSMVLNELRNAL 1154
            |.|:|||:|.:|:.||
Zfish  1091 KSVMGSMLLRQLKTAL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	381/580 (66%)
		HEAT repeat	48..73	CDD:293787	17/24 (71%)
		HEAT repeat	117..144	CDD:293787	26/26 (100%)
		Cnd1	129..>252	CDD:289487	96/122 (79%)
		HEAT repeat	147..179	CDD:293787	24/31 (77%)
		HEAT repeat	188..214	CDD:293787	17/25 (68%)
		AP3B1_C	881..1019	CDD:291462	44/137 (32%)
ap3b1a	XP_021324676.1	Adaptin_N	54..587	CDD:307641	377/569 (66%)
		HEAT repeat	124..152	CDD:293787	27/27 (100%)
		HEAT repeat	158..186	CDD:293787	21/27 (78%)
		HEAT repeat	195..221	CDD:293787	17/25 (68%)
		AP3B1_C	832..974	CDD:317233	51/153 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54550
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101595
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.930