DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rb and ap1b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	XP_009299618.1	Gene:	ap1b1 / 562166	ZFINID:	ZDB-GENE-061025-1	Length:	995	Species:	Danio rerio

Alignment Length:	1149	Identity:	285/1149 - (24%)
Similarity:	480/1149 - (41%)	Gaps:	266/1149 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|:|:|...|.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Zfish    33 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 97

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|:::::||.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Zfish    98 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 162

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..::.|:||...:||.:||.|..|:....     :||..:...||...|
Zfish   163 KLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPNSNLLDLNPQTINKLLTAL 227

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|..|                      ||                    .||
Zfish   228 NECTEWGQIFILDCLANY----------------------TP--------------------RDD 250

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL---YHH 361
            .:::|                               :..:..|.|...|::||::..::   :..
Zfish   251 RESQS-------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFME 284

  Fly   362 VAPKN------EVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTH 420
            :.||:      .::.:|..|:.||.:..|:|.|.|..|..:..||..|.:..:|.|||:.:||.:
Zfish   285 MLPKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIY 349

  Fly   421 IKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHL 485
            :||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.|:.|
Zfish   350 VKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 414

  Fly   486 LSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIA 550
            :.....:||.|::||||.:.:....::..:|..:.:.:|.::.|.||||:||::|||.|::. .|
Zfish   415 IQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID-NA 478

  Fly   551 PDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRARFLR 614
            .::|....:.|.||...|:||:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.....
Zfish   479 DELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYW 543

  Fly   615 QIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVI 679
            :::    .|..|.   |::|.||.||....|:...:..  .|..|..::...|:.|.:
Zfish   544 RLL----STDPVA---AKEVVLAEKPLISEETDLIEPT--LLDELICHIGTLASVYHK------- 592

  Fly   680 PPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESGSSS 744
            ||.:.|....|....:||                                            :.:
Zfish   593 PPSAFVEGSRGVQHKRLP--------------------------------------------ARA 613

  Fly   745 GSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNAR 809
            |||.|....:...||:|:        ..|..:.|..:.|.|..:.:||    |...|:
Zfish   614 GSGESAESPEVGQSGTSE--------APPAVIPSQGDLLGDLLNLDLA----PATTTV------- 659

  Fly   810 GSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL 874
                  .|...|...|:.  |...|..:.:..:|:.|     |........:.|:.::..|..:|
Zfish   660 ------PSVQPSMQMGAM--DLLGGGLDSLMGDESDT-----PGVSHRTEMQSPQPSSDYSEREL 711

  Fly   875 LLDLDDIPPIGPVM------------TPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHI 927
            ..|:...|.:|..:            .|::||.|.....:..|...|..        ..|.|..:
Zfish   712 GGDIGGSPSMGAALGAPAAMPAALSNAPAVGGGLGDLFDLGGGVGMPTG--------FYVAPKTL 768

  Fly   928 EFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQTTL---PA 987
                  .|..:...||.::..|.|     ...:..::|...|:....:|  ||:..:.:.   ||
Zfish   769 ------FLPAMKAKGLEISGTFAR-----RGGIIQMDLSLTNKAMSVMTDFAIQFNRNSFGLAPA 822

  Fly   988 G-MQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGE 1051
            | :|:     :|.|.|.||               :|:.|........::::|     :.::|:..
Zfish   823 GPLQV-----LTPLTPNQT---------------IDVSLPLGTTGPVMKMEP-----LNNLQVAV 862

  Fly  1052 ---------SCHREERAKLRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHSSSSGQLHC 1107
                     ||  :....|..:.:.:.|.:.......|:....:..|: |...|.:|.:
Zfish   863 KNNIDVFYFSC--QYPLSLLFVEDGKMERQVFLATWKDIPNDNEAQFQ-IKDVHLNSDA------ 918

  Fly  1108 FAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNELR 1151
             |...|...:  :.|:..:|.||..:|....|:..|..||.|:|
Zfish   919 -ASNKLQGSN--IFTIAKRTVDAQDMLYQSIKLTNGIWVLAEMR 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	184/590 (31%)
		HEAT repeat	48..73	CDD:293787	10/24 (42%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	8/27 (30%)
		AP3B1_C	881..1019	CDD:291462	29/155 (19%)
ap1b1	XP_009299618.1	Adaptin_N	27..550	CDD:279882	185/594 (31%)
		HEAT repeat	67..91	CDD:293787	13/23 (57%)
		HEAT repeat	103..130	CDD:293787	11/26 (42%)
		Cnd1	115..284	CDD:289487	55/241 (23%)
		HEAT repeat	137..167	CDD:293787	12/29 (41%)
		HEAT repeat	176..202	CDD:293787	8/25 (32%)
		HEAT repeat	213..244	CDD:293787	11/30 (37%)
		HEAT repeat	371..395	CDD:293787	8/23 (35%)
		HEAT repeat	407..435	CDD:293787	11/27 (41%)
		HEAT repeat	443..474	CDD:293787	12/30 (40%)
		HEAT repeat	480..506	CDD:293787	8/25 (32%)
		Alpha_adaptinC2	772..872	CDD:197886	22/129 (17%)
		B2-adapt-app_C	881..994	CDD:198088	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920