Protein Alignment rb and g

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1106
• Identity: 202/1106 - (18%)
• Similarity: 371/1106 - (33%)
• Gaps: 377/1106 - (34%)

  Fly    46 DDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQ 110
            :::||.|..:...:|..|:.::..:...|.|.|.....:::.:.|.....|::.|:...:.....
  Fly    42 EEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPD 106

  Fly   111 QDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADL-------SPYVR 168
            .:|.:|:.:..::.|...||.....||..||    ..|.|.:.   ||.|.|:       .||:|
  Fly   107 SELLMLTTNMIRKDLNSQNQYDAGVALSGLS----CFISPDLS---RDLANDIMTLMSSTKPYLR 164

  Fly   169 KTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNF 233
            ..|...:.|::                              :.:.|.       :...:.||...
  Fly   165 MKAVLMMYKVF------------------------------LRYPEA-------LRPAFPKLKEK 192

  Fly   234 LLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSD 298
            |.|.|...|...:|::...||.   :|.           ...|::..|:
  Fly   193 LEDPDPGVQSAAVNVICELARK---NPK-----------NYLPLAPIFF---------------- 227

  Fly   299 DEKNKSSTNNKNNG------GGNGSRTPSSP----------SNSYHIDVDHRLL----------L 337
                |..|.:.||.      ...|:.||..|          :|..|......||          |
  Fly   228 ----KLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECINTVIAVL 288

  Fly   338 RQTKPLLQSRNASVVMAVAQLYHHV--APKNEVQLIAKALIRLLRSH-KEVQS---VVLNCIASM 396
            ......:.:.:||:.:.|.:|...:  :.:|...|...|:.::|::| |.||:   ::|.|:...
  Fly   289 ISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDK 353

  Fly   397 STKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATI 461
            ...                     |:|..||:|..:.|..::..|::....::..::.|.....:
  Fly   354 DES---------------------IRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDEL 397

  Fly   462 --QAIGRCA-SSIKEVT--ETCLSGLVHLL-----SNHDEHVVAESVVVIKRLLQTKAAEHFEII 516
              :.|..|| ||...||  |..|:.||.|:     |.|. .::||.::.:  .::......| .:
  Fly   398 LYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHG-RLIAEQLLDV--AIRVPVVRQF-AV 458

  Fly   517 TQMAKLIDYINVPA-------ARAAIIWLIGEYNEKVP--------LIAPDVLRKMAKSFVDEQD 566
            .:|..|:|...|.|       ...|..|::||:..::.        |:.|.:|....:. |..|:
  Fly   459 NEMTNLLDTFTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRLLPGHIQG-VYVQN 522

  Fly   567 VVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARY---DPNYDVRDRA-------RFLRQ------ 615
            |:||........|.|.:......||.:|....::   ..:.:|::||       ..||.
  Fly   523 VIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTST 587

  Fly   616 -------------------------IIF-------------------------------PASGTS 624
                                     ::|                               |....|
  Fly   588 DAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPEDAAS 652

  Fly   625 SVLSQHAR-QVFLASKPA-----------------PVPESKYRDGNNFQLGSLSHYL-NMPAAG- 669
            |..|:|.: ::|:::..|                 |....:.|.....:..:..||| :.|.|.
  Fly   653 SSSSEHDKDELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLKSTPTASG 717

  Fly   670 ------YKELPAFPVIPPDSSVRNIAG-----------FMQDKLPGEDSPSGHSKDKSGREGGKE 717
                  |..:...|:......:..:|.           ::|::...:.|..|..|.|.|::..|.
  Fly   718 ASNADQYDNIDDIPITELPLDMEGVAALRVGITKRSDKYLQEQQAAQGSKDGKKKHKKGKKSKKA 782

  Fly   718 KG---------AGGE--------------KGF-LSESDDKSSAYSESG----------------- 741
            |.         :.||              :|. :|:|:||...|..:.
  Fly   783 KNKVAYNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDPNDPHRALDIELDITEFEAP 847

  Fly   742 ---SSSGSGTSDSE-----SDSDGSGSS-------DEEEEEVQKQQPTKVSSVKER--------- 782
               |:|....:|.|     :||.|.|::       |:::::.:|.:.....|.:||
  Fly   848 AVRSASKKSAADKENLKTPADSAGGGNAAKKDRKKDKDKDKERKVKREHRESKRERKEAAVQSVI 912

  Fly   783 -LIDAGSNELAATSSP--VKATINNNNNA--------------RGSSGTSDSEDSSAYSGSSSDD 830
             ||||.:    .|.||  :.||.||||.:              .....|.::.|:.|.:..||..
  Fly   913 DLIDADT----PTPSPSHISATSNNNNTSTVLPDAPKHHKKKKNKEKTTDEAPDALATATGSSII 973

  Fly   831 SASGSDNEVKKNETKTDTGTKPEKLKEKHE----KQPEQTAVKSNLDLLLDLDDI-PPIGPVMTP 890
            ...|        |..::..:|..|.|.|.|    |:.::.:..:::..::.:.|. .|:| :.||
  Fly   974 DVGG--------EEASEVASKVHKKKHKKEKSQRKEKKKASESASVSAIVSIGDYEQPLG-ISTP 1029

  Fly   891 S 891
            |
  Fly  1030 S 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	125/710 (18%)
		HEAT repeat	48..73	CDD:293787	5/24 (21%)
		HEAT repeat	117..144	CDD:293787	7/26 (27%)
		HEAT repeat	147..179	CDD:293787	11/38 (29%)
		HEAT repeat	188..214	CDD:293787	0/25 (0%)
		AP3B1_C	881..1019	CDD:464319	5/12 (42%)
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	121/639 (19%)
		AP3D1	687..840	CDD:461889	26/152 (17%)