DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and ap2b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	XP_012812114.1	Gene:	ap2b1 / 394814	XenbaseID:	XB-GENE-5871354	Length:	958	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	245/903 - (27%)
Similarity:	394/903 - (43%)	Gaps:	164/903 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|::.|...:.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Frog    17 ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|::::::|.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Frog    82 DMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..:..|::|...:||.:||.|..|:....     :||..:|..||...|
Frog   147 KLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|:.|                                           :..|
Frog   212 NECTEWGQIFILDCLSNY-------------------------------------------NPKD 233

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL---YHH 361
            |:...|                              :..:..|.|...|::||::..::   :..
Frog   234 EREAQS------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFLE 268

  Fly   362 VAPKNE------VQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTH 420
            :.||:.      ::.:|..|:.||....|||.|.|..|..:..||..|.:..:|.|||:.:||.:
Frog   269 LLPKDSDYYTMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY 333

  Fly   421 IKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHL 485
            :||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.|:.|
Frog   334 VKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 398

  Fly   486 LSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIA 550
            :.....:||.|::|||:.:.:....::..||..:.:.:|.::.|.||.|:||::|||.|::. .|
Frog   399 IQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGEYAERID-NA 462

  Fly   551 PDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRARFLR 614
            .::|....:.|.||...|:|.:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.....
Frog   463 DELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYW 527

  Fly   615 QIIFPASGTSSVLSQHARQVFLASKP-----APVPESKYRDGNNFQLGSLSHYLNMPAAGY---- 670
            :::    .|..|.   |::|.|:.||     ..:.|....|.....:|||:...:.|...:
Frog   528 RLL----STDPVT---AKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGS 585

  Fly   671 -----KELPA---------FPVIPPDSS-------VRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714
                 |.||.         .||.|..|:       :.:....:.|.|..:..|.|:....|..:.
Frog   586 HGVHRKHLPIQHGSIDIGDSPVGPTPSAGLEQPQVIPSQGDLLGDLLNLDLGPPGNVPQVSTMQM 650

  Fly   715 GKEKGAGGEKGFLSESDDKSSAYSESGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQP-TKVSS 778
            |.....||....|...|.:     ..||..|.|.         .||....:..:....| |...|
Frog   651 GAVDLLGGGLDSLMGEDTQ-----WLGSDLGGGI---------GGSPAVGQTFIPSSVPATFAPS 701

  Fly   779 VKERLIDAGSNELAATSSPV----------KATINNNNNARG--SSGTSDSEDSSAYSGSSSDDS 831
            ....::.:|.|:|...||.:          ||.......|:|  .|||.....:..|...|..:.
Frog   702 PTPAVVSSGLNDLFELSSGIGMAPGGYVSQKAVWLPAVKAKGLEISGTFSHRQAHIYMDMSFTNK 766

  Fly   832 ASGSDNEVKKNETKTDTGTKPEKLKEKHEK-QPEQTAVKSNLDLLLDLDDIPPIGPVM 888
            |.....:......|...|..|......|.. .|.|     ::|:.|.|:   .:||||
Frog   767 ALQHMTDFAIQFNKNSFGVIPSAPLAIHTPLMPNQ-----SIDISLPLN---TLGPVM 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	178/590 (30%)
		HEAT repeat	48..73	CDD:293787	8/24 (33%)
		HEAT repeat	117..144	CDD:293787	10/26 (38%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	7/27 (26%)
		AP3B1_C	881..1019	CDD:291462	4/8 (50%)
ap2b1	XP_012812114.1	Adaptin_N	11..534	CDD:366724	179/594 (30%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	7/25 (28%)
		HEAT repeat	197..228	CDD:293787	12/30 (40%)
		HEAT repeat	392..416	CDD:293787	9/23 (39%)
		HEAT repeat	428..457	CDD:293787	12/28 (43%)
		HEAT repeat	464..494	CDD:293787	10/29 (34%)
		HEAT repeat	505..541	CDD:293787	12/42 (29%)
		Alpha_adaptinC2	738..838	CDD:197886	21/87 (24%)
		B2-adapt-app_C	847..957	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920