DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and ap4b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_956632.1	Gene:	ap4b1 / 393309	ZFINID:	ZDB-GENE-040426-1284	Length:	729	Species:	Danio rerio

Alignment Length:	626	Identity:	153/626 - (24%)
Similarity:	269/626 - (42%)	Gaps:	127/626 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDS---NKDGLKLEA-MKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYA 107
            :||:.|.:   ..|.|:.:: :.::|..:.:|.|.|.||..:||...:.:|..|||||:|:..||
Zfish    12 ELKRALSNPNVQADRLRYKSYITKVIRYMTQGLDVSALFMDMVKASATVDIVQKKLVYLYMCTYA 76

  Fly   108 EEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIV-----PIVMLAIRDSAADLSPYV 167
            .::.|||||:|:|.::...|||.::|..|||.:.:.|:..:.     ||| ..:||.|:    ||
Zfish    77 SDKPDLALLAINTLRKDCADPNPMVRGLALRNMCNFRMPGMTEYIEQPIV-AGLRDKAS----YV 136

  Fly   168 RKTAAHAIPKLYSLD--ADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKN--YR 228
            |:.|.....|::||.  .:....||..:..||.|...:||.:.:.|.:::..:...::...  ..
Zfish   137 RRVAVLGCAKMHSLQPRTEIDGSLVNELYALLRDPDPVVVVNCLRALEDILKDEGGVVINKPIAH 201

  Fly   229 KLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSD 293
            .|.|.|.|:|.|.|..::..|.||.      |..|||               .:|
Zfish   202 HLLNRLKDLDCWAQSEVLTFLLRYR------PRNDDE---------------LFD---------- 235

  Fly   294 DGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL 358
                                                      :|....|.|||..:.|.::..:|
Zfish   236 ------------------------------------------ILSLLDPFLQSSQSHVAISTLRL 258

  Fly   359 YHHVA---PKNEVQLIAKALIRLL----RSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
            :.|:|   |..:...:..:...||    .:.:|::...|..|..:...:.|:|..|.|.||...|
Zfish   259 FLHLAAAHPAVQADALLCSSAPLLATCGAASRELRFAGLCHIQQVMRSQPALFNTHYKRFFCGYS 323

  Fly   417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSG 481
            :|::||..|::||..|.:..:::|:|.|.::|.:........|.|.||||..   :..:|.||..
Zfish   324 EPSYIKFRKMEILVALVNDENVALVLEEMKSYCTDVSAELAQAAIAAIGRIG---RTYSEKCLDI 385

  Fly   482 LVHLLSNHDEHVVAESVVVIKRLL----QTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEY 542
            |..||:...:|:.:..:...:.|:    |..||    :...:...:||......:.|::||:||:
Zfish   386 LTGLLALKQDHITSAVIQTFRDLVWFCPQCTAA----VCLTVESCVDYPQDSEGKQALLWLLGEH 446

  Fly   543 NEKVPLIAPDVLRKMAKSFVDE-QDVVKLQVLNLGVKLYLTNPEQT-SLLCQYVFTLARYDPNYD 605
            .:::. .||.:|.........| ...:|:::|...:|::|..|.:| .:|.:.:......:.:..
Zfish   447 ADQIS-SAPYLLEVYIDGLKTELSAALKMEILTAALKMFLRRPAETQDMLGRLLHYCIEEESDMC 510

  Fly   606 VRDRA----RFLRQIIFPASGTSSVLSQHARQVFLASKPAP 642
            |||||    |.|::.|           :..|:|....|..|
Zfish   511 VRDRALLYYRLLQRGI-----------EETRKVVTGPKSDP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	149/603 (25%)
		HEAT repeat	48..73	CDD:293787	6/28 (21%)
		HEAT repeat	117..144	CDD:293787	9/26 (35%)
		Cnd1	129..>252	CDD:289487	35/131 (27%)
		HEAT repeat	147..179	CDD:293787	11/36 (31%)
		HEAT repeat	188..214	CDD:293787	8/25 (32%)
		AP3B1_C	881..1019	CDD:291462
ap4b1	NP_956632.1	Adaptin_N	11..525	CDD:279882	148/598 (25%)
		HEAT repeat	86..113	CDD:293787	9/26 (35%)
		Cnd1	98..>225	CDD:289487	35/131 (27%)
		HEAT repeat	120..150	CDD:293787	11/34 (32%)
		HEAT repeat	159..185	CDD:293787	8/25 (32%)
		HEAT repeat	196..222	CDD:293787	7/25 (28%)
		HEAT repeat	233..257	CDD:293787	7/75 (9%)
		B2-adapt-app_C	614..718	CDD:286193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850