DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and copb1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_001002013.1	Gene:	copb1 / 338138	ZFINID:	ZDB-GENE-030219-38	Length:	953	Species:	Danio rerio

Alignment Length:	907	Identity:	178/907 - (19%)
Similarity:	323/907 - (35%)	Gaps:	237/907 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVS-KNIEVKKLVYVYLVRYAEEQQ 111
            ||..|:..:...|.||:|::|.||..|.....|...:::.|:. ::..:|||:.|:.....:...
Zfish    26 LKTDLEKGEIKAKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTP 90

  Fly   112 DLALLS-----ISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTA 171
            |..||.     ...:::.|:.||:.||.|.||.|..::.|.::..:|.|||........|||:.|
Zfish    91 DGKLLQEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKESELLEPLMPAIRACLERRHSYVRRNA 155

  Fly   172 AHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPER--VDLIHKNYRKLCNFL 234
            ..||..:|           ...|.|:.|...|:....|...|..|...  :.|||.:..:..::|
Zfish   156 VLAIYTIY-----------RNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYL 209

  Fly   235 ---LD-VDEWG---QVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHS 292
               :| |..:|   |::|:.::.:....                   .|.....:....::...|
Zfish   210 STCIDQVHTFGDILQLVIVELIYKVCHA-------------------NPSERARFIRCIYNLLQS 255

  Fly   293 DDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQ 357
                                        |||:..|  :....|:...:.|       :.:.|.||
Zfish   256 ----------------------------SSPAVKY--EAAGTLVTLSSAP-------TAIKAAAQ 283

  Fly   358 LYHHVAPK---NEVQLIAKALIRLLRSH----KEVQSVVLNCIASMSTK----RKAIFEPHLKSF 411
            .|..:..|   |.|:||....:..|:.|    :.:|.:|::.:..::|.    ||...:..|...
Zfish   284 CYIDLIIKESDNNVKLIVLDRLIELKEHPTHERVLQDLVMDILRVLTTPDLEVRKKTLQLALDLV 348

  Fly   412 FVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTE 476
            ..|..:...|.|.|..|.||..             |....:|: :....::.:..|:....::..
Zfish   349 SSRNVEELVIVLKKEVIKTNNV-------------TEHEDTDK-YRQLLVRTLHSCSVRFPDMAA 399

  Fly   477 TCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFE-----IITQMAKLIDYINVPAARAAII 536
            ..:..|:..||:.:|...|:.:..::     :|.:.|:     ||.:|.::...|.........:
Zfish   400 NVIPVLMEFLSDTNEAAAADVLEFVR-----EAIQRFDNLRPLIIEKMLEVFHAIKTVKIYRGAL 459

  Fly   537 WLIGEYNE-----------------KVPLIAPDVLRKMAKSFVDEQDVV-----KLQVLNLGVKL 579
            |::|||..                 ::|::..: |:|.|.....|::|.     || |..:|.
Zfish   460 WILGEYCSTKEDIQSVMTEVRRSLGEIPIVENE-LKKEAGEVKPEEEVTAAPAPKL-VTEMGT-- 520

  Fly   580 YLTNPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQII-----FPASGTSSVLSQHA-RQVFLAS 638
            |:|         |...:.:|  |:....||.. ||..:     :.|:..::.|::.| |.|.||
Zfish   521 YVT---------QSALSTSR--PSKKEEDRPP-LRGFLMDGDFYVAASLATTLTKVALRYVALA- 572

  Fly   639 KPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSP- 702
                  |.|.|. |:|...::.....:...|...||..|:  .|..|..|:..:  |:..|.||
Zfish   573 ------EDKRRQ-NSFVAEAMLIMATVLHLGKSSLPKKPI--TDDDVDRISLCL--KVLSECSPL 626

  Fly   703 ------------SGH------SKDKSGREGGKEKGAGGEKGFLSESDDKSS-----AYSESGSS- 743
                        ..|      .::|..::...||     :....::||..|     |.:|..|.
Zfish   627 MNDIFNKECRRSLSHMLAVRLEEEKLSQKKESEK-----RNVTVQADDPISFMQLTAKNEMASKE 686

  Fly   744 --------SGSGTSDSESDSDG-----------SGSSDEEEEE---------------VQKQQPT 774
                    :..|.:..:..:|.           :|.||....|               |..|...
Zfish   687 DQFQLSLLAAMGNTQRKEATDPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSD 751

  Fly   775 KVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSD 836
            .:.:....|...|..:|....||:....::..|.:.:...:.:|:...:.....|.|.:.||
Zfish   752 TLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASD 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	126/630 (20%)
		HEAT repeat	48..73	CDD:293787	10/24 (42%)
		HEAT repeat	117..144	CDD:293787	9/31 (29%)
		Cnd1	129..>252	CDD:289487	35/131 (27%)
		HEAT repeat	147..179	CDD:293787	10/31 (32%)
		HEAT repeat	188..214	CDD:293787	5/25 (20%)
		AP3B1_C	881..1019	CDD:291462
copb1	NP_001002013.1	Adaptin_N	26..550	CDD:279882	126/625 (20%)
		HEAT 1. /evidence=ECO:0000255	96..131		9/34 (26%)
		HEAT 2. /evidence=ECO:0000255	132..168		11/46 (24%)
		HEAT repeat	137..161	CDD:293787	10/23 (43%)
		HEAT repeat	173..211	CDD:293787	8/37 (22%)
		HEAT repeat	221..272	CDD:293787	9/99 (9%)
		HEAT 3. /evidence=ECO:0000255	240..276		7/72 (10%)
		HEAT 4. /evidence=ECO:0000255	277..314		11/36 (31%)
		HEAT repeat	280..307	CDD:293787	9/26 (35%)
		HEAT 5. /evidence=ECO:0000255	316..353		7/36 (19%)
		HEAT repeat	318..342	CDD:293787	5/23 (22%)
		HEAT 6. /evidence=ECO:0000255	396..433		7/41 (17%)
		Coatamer_beta_C	667..807	CDD:285019	21/139 (15%)
		Coatomer_b_Cpla	816..944	CDD:291472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910