DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and ap2b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_956213.2	Gene:	ap2b1 / 334632	ZFINID:	ZDB-GENE-030131-6564	Length:	951	Species:	Danio rerio

Alignment Length:	1001	Identity:	252/1001 - (25%)
Similarity:	410/1001 - (40%)	Gaps:	239/1001 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|::.|...:.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Zfish    17 ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|::::::|.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Zfish    82 DMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..:..|::|...:||.:||.|..|:....     :||..:|..||...|
Zfish   147 KLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|:.|                                           :..|
Zfish   212 NECTEWGQIFILDCLSNY-------------------------------------------NPKD 233

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL---YHH 361
            |:...|                              :..:..|.|...|::||::..::   :..
Zfish   234 EREAQS------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFLE 268

  Fly   362 VAPKNE------VQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTH 420
            :.||:.      ::.::..|:.||....|||.|.|..|..:..||..|.:..:|.|||:.:||.:
Zfish   269 LLPKDSDYYNTLLKKLSPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY 333

  Fly   421 IKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHL 485
            :||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.|:.|
Zfish   334 VKLEKLDIMIRLASHANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 398

  Fly   486 LSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIA 550
            :.....:||.|::|||:.:.:....::..||..:.:.:|.::.|.||.|:||::|||.|::. .|
Zfish   399 IQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGEYAERID-NA 462

  Fly   551 PDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRARFLR 614
            .::|....:.|.||...|:|.:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.....
Zfish   463 DELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYW 527

  Fly   615 QIIFPASGTSSVLSQHARQVFLASKP-----APVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674
            :::    .|..|.   |::|.|:.||     ..:.|....|.....:|||       |:.|.:
Zfish   528 RLL----STDPVT---AKEVVLSEKPLISEETDLIEPTLLDELICHIGSL-------ASVYHK-- 576

  Fly   675 AFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSE 739
                 ||::.|....|..:..||.:     |....:|                           |
Zfish   577 -----PPNAFVEGSHGIHRKHLPIQ-----HGSIDTG---------------------------E 604

  Fly   740 SGSSSGSGTS-DSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATIN 803
            |..|:|...| |........|....:...:....|..|..|       .|.::||...
Zfish   605 SPVSTGPAASIDQPQVIPSQGDLLGDLLNLDLGPPVNVPQV-------SSMQIAAVDL------- 655

  Fly   804 NNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAV 868
                   ..|..||.......|......|.| .|.:            |..:.......|...|:
Zfish   656 -------LGGGLDSLLGGDLGGGVGGSPAVG-QNFI------------PSSVPNTFAPSPTPAAL 700

  Fly   869 KSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKE 933
            .|.|:.|.:|      ...|..:.||::...|..
Zfish   701 SSGLNDLFEL------STGMATATGGYVAAKTVW------------------------------- 728

  Fly   934 LLNKVSGHGLHLAYRFT-RSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQ--------TTLPA 987
             |..|...||.::..|: |..|:|      :::.|.|:..:.:|  ||:..:        |.||.
Zfish   729 -LPAVKAKGLEISGTFSRRQGHMY------MDMTFTNKALQHMTDFAIQFNKNSFGVIPTTPLPV 786

  Fly   988 GMQLNEFAPITVLQPQQTASGVLGVD 1013
            ...|.....|.:..|..|...|:.:|
Zfish   787 HTPLMPSQSIDISLPLNTIGPVMKMD 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	177/590 (30%)
		HEAT repeat	48..73	CDD:293787	8/24 (33%)
		HEAT repeat	117..144	CDD:293787	10/26 (38%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	7/27 (26%)
		AP3B1_C	881..1019	CDD:291462	26/144 (18%)
ap2b1	NP_956213.2	Adaptin_N	11..534	CDD:279882	178/594 (30%)
		HEAT repeat	15..42	CDD:293787	8/24 (33%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..268	CDD:289487	53/241 (22%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	7/25 (28%)
		HEAT repeat	197..228	CDD:293787	12/30 (40%)
		HEAT repeat	392..416	CDD:293787	9/23 (39%)
		HEAT repeat	428..457	CDD:293787	12/28 (43%)
		HEAT repeat	464..494	CDD:293787	10/29 (34%)
		HEAT repeat	505..541	CDD:293787	12/42 (29%)
		Alpha_adaptinC2	731..831	CDD:197886	21/88 (24%)
		B2-adapt-app_C	840..950	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850