Protein Alignment rb and AP-1-2beta

DIOPT Version :9

• Sequence 1: NP_001162664.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_523415.1
• Gene: AP-1-2beta / 32987
• FlyBaseID: FBgn0010380
• Length: 921
• Species: Drosophila melanogaster
• Alignment Length: 1015
• Identity: 266/1015 - (26%)
• Similarity: 432/1015 - (42%)
• Gaps: 239/1015 - (23%)

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|:::|...|.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
  Fly    17 ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
  Fly    82 DMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER------VDLIHKNYRKLCNF 233
            |||.:.|...::  .:..::.||||...:||.:||.|..|:....      |::......||...
  Fly   147 KLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTA 211

  Fly   234 LLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSD 298
            |.:..|||||.|::.|..|                                           |..
  Fly   212 LNECTEWGQVFILDSLANY-------------------------------------------SPK 233

  Fly   299 DEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMA----VAQLY 359
            ||:...|                              :..:..|.|...||:||::    :.:|.
  Fly   234 DEREAQS------------------------------ICERITPRLAHANAAVVLSAVKVLMKLL 268

  Fly   360 HHVAPKNE-----VQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPT 419
            ..::..::     .:.:|..|:.||.|..|||.|.|..|..:..||..|.:..:|.|||:.:||.
  Fly   269 EMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPI 333

  Fly   420 HIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVH 484
            ::||.||||:..||:..:|:.:|.|.:.|.:..|..||...::||||||..::...|.|:|.|:.
  Fly   334 YVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLD 398

  Fly   485 LLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLI 549
            |:.....:||.|::||||.:.:....::..||:.:.:.:|.::.|.|||:::|:||||.|::. .
  Fly   399 LIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERID-N 462

  Fly   550 APDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRARFL 613
            |.::|....:.|.||...|:||:|...|||:|..|..|..|.|:|.:||..| .|.|:|||....
  Fly   463 ADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIY 527

  Fly   614 RQIIF--PASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAF 676
            .:::.  ||:         |::|.||.||....|:...:..  .|..|..:::..|:.|.:
  Fly   528 WRLLSTDPAA---------AKEVVLADKPLISEETDLLEPT--LLDELICHISSLASVYHK---- 577

  Fly   677 PVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESG 741
               ||.:.|                           ||   :|||..|...:.:         :|
  Fly   578 ---PPTAFV---------------------------EG---RGAGVRKSLPNRA---------AG 600

  Fly   742 SSSGSGTSDSESDSDGSGSSDEE-----------EEEVQKQQPTKVSSVKERLIDAGSNEL---- 791
            |::|:..:::.:.|:.....::|           ........|...|:|.  |:..|.:.|
  Fly   601 SAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVD--LLGGGLDILLGGP 663

  Fly   792 AATSSPVKAT-----INNNNNARGSSGTSDSE----DSSAYSGSSSDDSASGSDNEVKKNETKTD 847
            .|.::|..||     |.....|..|.|....:    .:....|.....:.|..:.||..:.|.|:
  Fly   664 PAEAAPGGATSLLGDIFGLGGATLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTN 728

  Fly   848 TGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQP 912
            ...:|                .:|..:.|:.:           |.|  |.|.:||   |||||.|
  Fly   729 KAMQP----------------MTNFAIQLNKN-----------SFG--LVPASPM---QAAPLPP 761

  Fly   913 QHARNRVELV------GPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRG 971
            ..:   :|:.      ||    .:..|.||     .|.:|.: ......|.:.:....:.|...|
  Fly   762 NQS---IEVSMALGTNGP----IQRMEPLN-----NLQVAVK-NNIDIFYFACLVHGNVLFAEDG 813

  Fly   972 EKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLG 1011
            :.:..........:||..:|           |.|.|||:|
  Fly   814 QLDKRVFLNTWKEIPAANEL-----------QYTLSGVIG 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	185/593 (31%)
		HEAT repeat	48..73	CDD:293787	9/24 (38%)
		HEAT repeat	117..144	CDD:293787	10/26 (38%)
		Cnd1	129..>252	CDD:289487	46/130 (35%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	9/27 (33%)
		AP3B1_C	881..1019	CDD:291462	32/137 (23%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	176/570 (31%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	58/242 (24%)
		HEAT repeat	121..151	CDD:293787	13/29 (45%)
		HEAT repeat	160..186	CDD:293787	9/25 (36%)
		HEAT repeat	197..229	CDD:293787	11/31 (35%)
		HEAT repeat	393..417	CDD:293787	9/23 (39%)
		HEAT repeat	429..458	CDD:293787	12/28 (43%)
		HEAT repeat	465..495	CDD:293787	11/29 (38%)
		HEAT repeat	506..542	CDD:293787	12/44 (27%)
		Alpha_adaptinC2	703..799	CDD:197886	29/140 (21%)
		B2-adapt-app_C	809..919	CDD:198088	11/45 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24905at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950