DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and Ap3b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_001101116.1	Gene:	Ap3b1 / 309969	RGDID:	1310256	Length:	794	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	367/842 - (43%)
Similarity:	505/842 - (59%)	Gaps:	91/842 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 MAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSD 417
            |||||||.|::|::|..:|:|:|:||||||:|||.:||..||:||.:||.:|||:||||:||::|
  Rat     1 MAVAQLYWHISPRSEAGVISKSLVRLLRSHREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTD 65

  Fly   418 PTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGL 482
            ||.||.|||:||||||:..:||.:|||||||:.|.|:.|.|||||.|||||:||.|||:|||:||
  Rat    66 PTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDKQFAAATIQTIGRCATSIAEVTDTCLNGL 130

  Fly   483 VHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVP 547
            |.||||.||.||||||||||:|||.:.|:|.|||..||||:|.|.||.|||:|:|||||..|:||
  Rat   131 VCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVP 195

  Fly   548 LIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDRARF 612
            .|||||||||||||..|.|:||||:||||.||||||.:||.||.||:..|.:||.|||:|||.||
  Rat   196 KIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRF 260

  Fly   613 LRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFP 677
            :||:|.| :..|..||::|:::|||.||||:.||.::|.::||||:|||.||:.|:||.||..:|
  Rat   261 IRQLIVP-NEKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNVKASGYLELSNWP 324

  Fly   678 VIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDK--------- 733
            .:.||.||||:......|   |.:|.|.:|        |||   .||.|.|||:::
  Rat   325 EVAPDPSVRNVEVIESAK---EWTPLGKTK--------KEK---PEKKFYSESEEEEEEEEEDEE 375

  Fly   734 --------SSAYSESGS---SSGSGTSDSESDSDGSGSSDEE---EEEVQKQQPTKVSSVKERLI 784
                    ||:.|||||   |..||:|..:|..|.|...|.|   |.|.:.|:..|.:|..:|..
  Rat   376 DEEEDPSDSSSDSESGSGRESGDSGSSSEDSSEDSSSGQDSETGSEAEAEHQRVAKTNSKTKRKS 440

  Fly   785 DAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTG 849
            .:...|              ..|.:..:..|.||:||:...||| :|.||||:|
  Rat   441 ASEDRE--------------KKNGKSQASESSSEESSSTEESSS-ESESGSDSE----------- 479

  Fly   850 TKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDDIPPIG-PVMTPSLGGFLTPG-TPMMAGQAAPLQ 911
            ..|.|..:..|::|:|.....:.|: ||||||..|:. ||..|      ||. :|.:......|.
  Rat   480 PAPRKTAKAKERKPQQERHPPSKDVFLLDLDDFNPVSTPVALP------TPALSPSLIADLEGLN 538

  Fly   912 PQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEIT 976
            ...:.:.:.:..|..:..|..|||:::.|.||...|.|.|.|.::...|.|:::...|..:.:|.
  Rat   539 LSTSSSIINVSTPVFVPTKTHELLHRMRGKGLAAHYCFPRQPCIFGDKMVSVQITLTNTSDGKIE 603

  Fly   977 AIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVG 1041
            .|.:|...|..|:|::.|.||..|:|:.:.:..:|:||.|||.....:|.:......:.::||||
  Rat   604 NIHVGGKKLAVGVQMHVFHPIESLEPEGSVTVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVG 668

  Fly  1042 ELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHS--SSSGQ 1104
            ||:..|.:.|...::|:..|.||||....|....|:....:.| |||   :|||:..:  ||...
  Rat   669 ELLLPVAMSEKDFKKEQGMLTGMNETSATLIAAPQNFTPSMIL-QKV---VNVANLGAVPSSQDN 729

  Fly  1105 LH------------CFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNELRNAL 1154
            :|            .||.:|:.|.||:|:|::.|......|::|.||.||||::|.||:..|
  Rat   730 IHRYERLKFQVLQERFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	180/267 (67%)
		HEAT repeat	48..73	CDD:293787
		HEAT repeat	117..144	CDD:293787
		Cnd1	129..>252	CDD:289487
		HEAT repeat	147..179	CDD:293787
		HEAT repeat	188..214	CDD:293787
		AP3B1_C	881..1019	CDD:291462	39/139 (28%)
Ap3b1	NP_001101116.1	Adaptin_N	<1..269	CDD:279882	180/268 (67%)
		SEEEED	<413..>454	CDD:291463	10/54 (19%)
		AP3B1_C	502..646	CDD:291462	46/149 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337030
Domainoid	1	1.000	757	1.000	Domainoid score	I86
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I280
OMA	1	1.010	-	-		QHG54550
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	1	1.000	-	-		otm45529
orthoMCL	1	0.900	-	-		OOG6_101595
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910