DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rb and Ap3b2

DIOPT Version :9

Sequence 1:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster
Sequence 2:NP_001101002.2 Gene:Ap3b2 / 308777 RGDID:1308950 Length:1082 Species:Rattus norvegicus


Alignment Length:1157 Identity:601/1157 - (51%)
Similarity:761/1157 - (65%) Gaps:125/1157 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 EFGADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVS 90
            |:|.||||| ..|.||.::|||||:|||:|||.|||||||||:.|||||::||||||||||||..
  Rat    21 EYGHDPASG-GIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVAC 84

  Fly    91 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLA 155
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||.:||||:|||
  Rat    85 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLA 149

  Fly   156 IRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERV 220
            |:::|:|:|||||||||||||||||||:||||:|:.||||||:|:||||.||.||||:||||||:
  Rat   150 IKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERI 214

  Fly   221 DLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDES 285
            ||||||||||||.|:||:|||||:||:||||||||||:.|..      |:.|.|....:.||   
  Rat   215 DLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQ------NESLLEENPEKAFY--- 270

  Fly   286 SHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNS-YHIDVDHRLLLRQTKPLLQSRNA 349
                     ||.:||        ....|...:.|.:.|:.. |.:|.|||||||.||||||||:|
  Rat   271 ---------GSEEDE--------AKGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSA 318

  Fly   350 SVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVR 414
            :|||||||||.|:|||.||.:|||||:||||||.|||.|||..:|:||.||:.:|||:||||::|
  Rat   319 AVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIR 383

  Fly   415 TSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCL 479
            ::|||.||:|||::|||||:..:|..:||||||||.|.|:.|||||||||||||::|..|.:|||
  Rat   384 STDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCL 448

  Fly   480 SGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNE 544
            :|||.||||.||.||||||||||:|||.:.|:|.|||..:|||.|.|.||.|||:|:||||||.|
  Rat   449 NGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513

  Fly   545 KVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDR 609
            .||.|||||||||||||..|:|:|||||:||..||||||.:||.||.|||.:||:||.|||:|||
  Rat   514 HVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDR 578

  Fly   610 ARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674
            |||.||:|.| |.....||:||:::|||.||||:.||.::|.::||||||||.||..|.||:|||
  Rat   579 ARFTRQLIAP-SEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQLGSLSHLLNAKATGYQELP 642

  Fly   675 AFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEK----GAGGEKGFLSESDDKSS 735
            .:|...||.||||:      ::|.....|...|.|.     |||    .:.||.|....:|.:..
  Rat   643 DWPEEAPDPSVRNV------EVPEWTKCSNREKRKE-----KEKPFYSDSEGESGPTESADSEPE 696

  Fly   736 AYSESG----SSSGSGTSDSESDSD------GSGS-SDEEEEEVQKQQPTKVSSVKERLIDAGSN 789
            :.||||    |.||||.|.||||::      |.|| |::.|||.:|::.||.....|     |..
  Rat   697 SESESGSKSSSESGSGESSSESDNEDDDEEKGEGSESEQSEEEGEKKKKTKKKKASE-----GHR 756

  Fly   790 ELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEK 854
            |                   |||    ||:.|        ||:|.|::||.....:..  .:|..
  Rat   757 E-------------------GSS----SEEGS--------DSSSSSESEVTSESEEEQ--VEPAS 788

  Fly   855 LKEKHEKQPEQTAVKSNLDLLLDLDD-----IPPIGP--VMTPSLGGFLTPGTPMMAGQAAP--L 910
            .::|.....:.|.....:. ||||:|     :.|:.|  |::.||...| .|..:......|  |
  Rat   789 WRKKTPPSSKSTPAAKEIS-LLDLEDFTSPSVQPVSPPMVVSTSLAADL-EGLTLTDSSLVPSLL 851

  Fly   911 QPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEI 975
            .|      |..:|       .:|||::|:|.||.:.|.|:|.|......|.|:.:.|.|..|..|
  Rat   852 SP------VSSIG-------RQELLHRVAGEGLAVDYAFSRQPFSGDPHMVSLHIYFSNNSETPI 903

  Fly   976 TAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKPPV 1040
            ..:.:|...||||:.:.||..|..|.|.::.:.|:|::|.|||.|.:.:|.:......:.::|||
  Rat   904 KGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQAANFQLCTQTRQFYVSIQPPV 968

  Fly  1041 GELVRSVQIGESCHREERAKLRGMNEHQCELR---GLRQDLIDVVALRQKVFESINVAHTHSSSS 1102
            |||:..|.:.|:..::|:.||.||||...:|.   ..|.|.:.|    |||..:.|:......:|
  Rat   969 GELMAPVFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVV----QKVTATANLGRVPCGAS 1029

  Fly  1103 GQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNELRNAL 1154
            .: :.|||:||:|.||||||||.:...|..|.||.||||||:|::.::..||
  Rat  1030 DE-YRFAGRTLTSGSLVLLTLDARGTGAAQLTVNSEKMVIGTMLVKDVIQAL 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 399/581 (69%)
HEAT repeat 48..73 CDD:293787 19/24 (79%)
HEAT repeat 117..144 CDD:293787 25/26 (96%)
Cnd1 129..>252 CDD:289487 99/122 (81%)
HEAT repeat 147..179 CDD:293787 24/31 (77%)
HEAT repeat 188..214 CDD:293787 18/25 (72%)
AP3B1_C 881..1019 CDD:291462 44/141 (31%)
Ap3b2NP_001101002.2 Adaptin_N 34..590 CDD:366724 399/582 (69%)
HEAT repeat 111..139 CDD:293787 26/27 (96%)
HEAT repeat 145..173 CDD:293787 21/27 (78%)
HEAT repeat 182..208 CDD:293787 18/25 (72%)
AP3B1_C 804..947 CDD:373301 49/157 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337029
Domainoid 1 1.000 757 1.000 Domainoid score I86
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1002 1.000 Inparanoid score I280
OMA 1 1.010 - - QHG54550
OrthoDB 1 1.010 - - D147356at33208
OrthoFinder 1 1.000 - - FOG0002006
OrthoInspector 1 1.000 - - otm45529
orthoMCL 1 0.900 - - OOG6_101595
Panther 1 1.100 - - O PTHR11134
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1748
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.910

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