DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rb and Ap1b1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	XP_038947721.1	Gene:	Ap1b1 / 29663	RGDID:	2064	Length:	952	Species:	Rattus norvegicus

Alignment Length:	1170	Identity:	294/1170 - (25%)
Similarity:	473/1170 - (40%)	Gaps:	335/1170 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|:|:|...|.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
  Rat    17 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|:::::||.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
  Rat    82 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..::.|:||...:||.:||.|..|:....     :||..::..||...|
  Rat   147 KLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|..|.                                          ..||
  Rat   212 NECTEWGQIFILDCLANYM------------------------------------------PKDD 234

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL------ 358
            .:.:|                               :..:..|.|...|::||::..::
  Rat   235 REAQS-------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFME 268

  Fly   359 -------YHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
                   |:....|.    :|..|:.||.:..|:|.|.|..|..:..||..|.:..:|.|||:.:
  Rat   269 MLSKDLDYYATLLKK----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYN 329

  Fly   417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSG 481
            ||.::||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.
  Rat   330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394

  Fly   482 LVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKV 546
            |:.|:.....:||.|::||||.:.:....::..:|..:.:.:|.::.|.||||:||::|||.|::
  Rat   395 LLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERI 459

  Fly   547 PLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRA 610
            . .|.::|......|.||...|:||:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.
  Rat   460 D-NADELLESFLDGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRG 523

  Fly   611 RFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPA 675
            ....:::    .|..|.   |::|.||.||....|:...:..  .|..|..|:...|:.|.:
  Rat   524 YIYWRLL----STDPVA---AKEVVLAEKPLISEETDLIEPT--LLDELICYIGTLASVYHK--- 576

  Fly   676 FPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSES 740
                ||::.|                           |||        :|.:.:|....:|.|||
  Rat   577 ----PPNAFV---------------------------EGG--------RGVVHKSLPPRTASSES 602

  Fly   741 GSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELA-ATSSPVKATINN 804
                   |...|:...|:.:||         ||..:.:..:.|.|..:.:|. ..|.|..|.
  Rat   603 -------TESPEAAPAGAPASD---------QPDVIPAQGDLLGDLLNLDLGPPVSGPPLAA--- 648

  Fly   805 NNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTA-- 867
                           ||...| :.|....|.|:.:         |.:||.:.:.:...|..:.
  Rat   649 ---------------SSVQMG-AVDLLGGGLDSLM---------GDEPEGIGDSNFGAPPASVAA 688

  Fly   868 ---------VKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVG 923
                     |.|.|..|.|                  ||.|...::|              ..|.
  Rat   689 AAPARLGAPVSSGLSDLFD------------------LTSGVGTLSG--------------SYVA 721

  Fly   924 PSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQTTL- 985
            |..:      .|..:...||.::..|||     .....|::||..|:..:.:|  ||:..:.:.
  Rat   722 PKAV------WLPAMKAKGLEISGTFTR-----QVGSISMDLQLTNKALQVMTDFAIQFNRNSFG 775

  Fly   986 --PAGMQLNEFAPITV---LQPQQTASGVLGVDFNDSTHAVDLEL-LSSAGSSRLQLKPPVGEL- 1043
              ||       ||:.|   |.|.||               |::.| |::.||  :....|:..|
  Rat   776 LAPA-------APLQVHAPLSPNQT---------------VEISLPLNTVGS--VMKMEPLNNLQ 816

  Fly  1044 -------------------VRSVQIGESCHREERAKLRGM---NEHQCELRGLRQDLIDVVALRQ 1086
                               |..|:.|:...:...|..:.:   ||.|.::|..
  Rat   817 VAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKDIPNENEAQFQIRDC------------ 869

  Fly  1087 KVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNELR 1151
                   ..:|.::||         .|.|.:  :.|:..:|.:...:|....|:..|..||.|||
  Rat   870 -------PLNTEAASS---------KLQSSN--IFTVAKRTVEGQDMLYQSLKLTNGIWVLAELR 916

Fly 1152 1151
Rat 917 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	182/594 (31%)
		HEAT repeat	48..73	CDD:293787	10/24 (42%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	8/27 (30%)
		AP3B1_C	881..1019	CDD:291462	28/145 (19%)
Ap1b1	XP_038947721.1	Adaptin_N	11..534	CDD:396262	183/598 (31%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	11/26 (42%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	8/25 (32%)
		HEAT repeat	197..228	CDD:293787	11/30 (37%)
		HEAT repeat	392..416	CDD:293787	9/23 (39%)
		HEAT repeat	428..457	CDD:293787	12/28 (43%)
		HEAT repeat	464..494	CDD:293787	11/29 (38%)
		HEAT repeat	505..541	CDD:293787	12/42 (29%)
		Alpha_adaptinC2	729..829	CDD:197886	28/128 (22%)
		B2-adapt-app_C	838..951	CDD:198088	22/109 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920