Protein Alignment rb and apl6

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_593796.1
• Gene: apl6 / 2541771
• PomBaseID: SPAC23H3.06
• Length: 745
• Species: Schizosaccharomyces pombe
• Alignment Length: 820
• Identity: 255/820 - (31%)
• Similarity: 405/820 - (49%)
• Gaps: 146/820 - (17%)

  Fly    33 SGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKK 97
            |.:..|:.:...|.||.::|:||.|..||||:..|:..:..|.:.|..||.|||.|.|:|.|:::
pombe    23 SSSLSFEENELSHSDLLRLLNSNSDAGKLEAINFILAQMMHGENMSLYFPDVVKLVASENPEIRR 87

  Fly    98 LVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAAD 162
            ||::||::|||...||||||::|.|:.|.|.|.|.|::|:||:|||||..|..||:|||:....|
pombe    88 LVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITD 152

  Fly   163 LSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNY 227
            .:..||::||.||.|.||||...|.:|...|:.||||.:.:||.:|:..|:.||||::::||..|
pombe   153 TADRVRQSAALAITKCYSLDPSYKSQLEEHIKTLLSDNSPIVVPAALFTFEVVCPEKLEIIHPYY 217

  Fly   228 RKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHS 292
            .::|.....:::|.:|:.:..|.||||....:|:             ||            |:||
pombe   218 HRICTLFPQMNDWDKVVALKTLVRYARLTLPEPS-------------TP------------STHS 257

  Fly   293 DDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQ 357
                                                   |.:.||...|....|...|.::|.|:
pombe   258 ---------------------------------------DLKELLESIKSCFFSLLPSTIIAGAR 283

  Fly   358 LYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIK 422
            .::::||.|::.||.:.|::||.....|::..|..|:.:..|...:|:.|:||||:..||.....
pombe   284 AFYYLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSDDTC 348

  Fly   423 LLKLDILTNLASAGSISLILREFQTYISSSDRSFVAAT-IQAIGRCASSIKEVTETCLSGLVHLL 486
            |||::||:.|..|.:.|.||.|...||:|.....||:| ::|:|..||:...:..:||:.|:.||
pombe   349 LLKINILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPSCLNTLLLLL 413

  Fly   487 SNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAP 551
            .:|:..:|.|:...::.|:.....|.:  :..:|...:.:.||.|::..:|||.|:...:|.:.|
pombe   414 KSHNSLIVTEAASSLRLLIHNDPKEIY--LQYLAATYETLEVPRAKSVTLWLISEHILIIPRLVP 476

  Fly   552 DVLRKMAKSFVDEQDVVKLQVLNLGVKLY-LTNPEQ-----------TSLLCQYVFTLARYDPNY 604
            ||||...|:|.||...||.|:|.|.|:|| |::.|:           .|||..||.:|..:|.:|
pombe   477 DVLRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLIHFDMSY 541

  Fly   605 DVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGN---------NFQLGSLS 660
            |:||||||.:::      .|:..|:..|::.|.||           ||         ::.:|:.|
pombe   542 DLRDRARFYKEL------ASTPSSEFTRRIVLESK-----------GNSQKEIIASRDYCIGTAS 589

  Fly   661 HYLNMPAAGYKELPAFPVI---PPDSSVRNIAGFMQDKLP---------GEDSP--SGHSKDKSG 711
            ..||....||:.:|.:..:   ||||....|    :|.||         ..:||  ...|.|...
pombe   590 LCLNEDVMGYEPIPNWADVSDLPPDSVREGI----KDVLPINPHTGNIYSNNSPGVKALSSDNFK 650

  Fly   712 REGGKEKGAGGEKGFLSESDDKSSAYSESGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKV 776
            |:.|........| |:.:     ....|..:|..|.:|:.|.::..|.|.|||.::..:::
pombe   651 RDFGDTNAINRPK-FVGQ-----QTLEEFYASETSESSEGEYETSTSESEDEETDDTSQEE---- 705

  Fly   777 SSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSD 816
                       .||  ..|:|.:.|.|||.::..:....|
pombe   706 -----------DNE--KNSTPDEDTENNNTSSISTKSIMD 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	203/593 (34%)
		HEAT repeat	48..73	CDD:293787	10/24 (42%)
		HEAT repeat	117..144	CDD:293787	13/26 (50%)
		HEAT repeat	147..179	CDD:293787	14/31 (45%)
		HEAT repeat	188..214	CDD:293787	10/25 (40%)
		AP3B1_C	881..1019	CDD:464319
apl6	NP_593796.1	COG5096	1..745	CDD:227427	255/820 (31%)
		HEAT repeat	71..95	CDD:293787	13/23 (57%)
		HEAT repeat	107..135	CDD:293787	14/27 (52%)
		HEAT repeat	141..170	CDD:293787	13/28 (46%)
		HEAT repeat	178..204	CDD:293787	10/25 (40%)