Protein Alignment rb and apl2

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: NP_595274.1
• Gene: apl2 / 2541255
• PomBaseID: SPBC947.02
• Length: 683
• Species: Schizosaccharomyces pombe
• Alignment Length: 799
• Identity: 194/799 - (24%)
• Similarity: 350/799 - (43%)
• Gaps: 180/799 - (22%)

  Fly    36 AFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVY 100
            ||.:|:   ..:|::.|.|.....:::|:||.|..:..|:|.|.|||.|:||:.:::|.:|||||
pombe    13 AFKKSE---TSELQKGLVSQYAYERIDAVKRTIAAMTVGKDVSSLFPDVLKNLATRDITLKKLVY 74

  Fly   101 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSP 165
            :||:.||:...||.:|:::||.:..::.|..:||.|:|.:..|||:.|:..:...:|.:..|..|
pombe    75 LYLINYAKTHPDLCILAVNTFVKDSEEYNPTLRALAIRTMGCIRVNKIIGYLADPLRKALKDEHP 139

  Fly   166 YVRKTAAHAIPKLYSLDAD--QKDELVMVIEKLLSDRTTLVVGSAVMAFDEV---CPER--VDLI 223
            ||||.||..:.|:|.||.:  ..:..:..::.|:||...:||.:||.:..|:   .||:  .:::
pombe   140 YVRKAAAVCVVKMYDLDREYCASNGFIEQLQALVSDPNPVVVANAVRSLAEIHDQDPEKGYFNVV 204

  Fly   224 HKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHS 288
            :....:|...|.:.:|||::.|:|.|.|: ||                   :.:.|..|
pombe   205 YTMTDRLMVALSECNEWGRITILNSLARF-RT-------------------SDIKEAEY------ 243

  Fly   289 SSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVM 353
                                                           :..:..|..|..|:.||:
pombe   244 -----------------------------------------------VCERVVPQFQHANSGVVL 261

  Fly   354 AVAQ----------------LYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKA 402
            :..:                ||..:||         .|:.||.:..|:|.|.|..|..:..||.:
pombe   262 SAVKVIMVHIPLFSSDFTDFLYKKMAP---------PLLTLLSTDSEIQYVALRNINLILQKRPS 317

  Fly   403 IFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRC 467
            ||:...:.||.:.:||.:||:.||.|:|.||...:|:..:.|.:.|:|..:..||..||:.:|..
pombe   318 IFDVKTRVFFCKYNDPLYIKMEKLKIITMLACDENINETISELRAYVSEVELEFVKQTIKCLGDV 382

  Fly   468 ASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAAR 532
            |..:..|...|:|..:.:...:..::|.|..||::.:|:....:...::..::::|:.:..|.||
pombe   383 ALKVPSVINDCISIFLEIYELNISYMVQEVTVVMETVLRKYPQKIDLLLPYLSRVIEELGDPRAR 447

  Fly   533 AAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPE-QTSLLCQYVFT 596
            :::.|::||::..:| .:..:|.:|..:..||...::|.:|...|||.|.|.: ....|.|.|..
pombe   448 SSMAWILGEFSHVIP-TSSKLLSEMISTMADEDLQIQLALLTAVVKLSLMNGKGNDEELVQKVLN 511

  Fly   597 LA-RYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLS 660
            .| ....|.|:||||...::::.|.:      .:.|:::....||                 |:|
pombe   512 YAINQSSNQDLRDRAFAYQRLLTPEN------VRKAQKIVCCEKP-----------------SVS 553

  Fly   661 HYLNMP--------------AAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSG 711
            :..|:|              |:.|.:||              ..|:.....|.|:....:.::..
pombe   554 YNNNLPEALLDALLCEITTLASVYHKLP--------------ESFIGQGKFGADAIQRRAVEELN 604

  Fly   712 REGGK-----EKGAGGEKGFLSESDDKSSAYSESGSSSGSGTS-DSESDSDGSGSSDE-----EE 765
            .|...     ||||..|.  |.:.|     :::.|::|.|.:. .|.....||.|:.:     |.
pombe   605 IEEANVHEAIEKGANVEN--LLDLD-----FTDPGATSASDSPITSAQPQSGSNSAMDLFMAFEA 662

  Fly   766 EEVQKQQPTKVSSVKERLI 784
            ......:|.|..|..:.|:
pombe   663 PSTNNAEPVKARSATDDLL 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	158/605 (26%)
		HEAT repeat	48..73	CDD:293787	7/24 (29%)
		HEAT repeat	117..144	CDD:293787	7/26 (27%)
		HEAT repeat	147..179	CDD:293787	11/31 (35%)
		HEAT repeat	188..214	CDD:293787	7/25 (28%)
		AP3B1_C	881..1019	CDD:464319
apl2	NP_595274.1	COG5096	1..677	CDD:227427	193/793 (24%)
		HEAT repeat	57..79	CDD:293787	11/21 (52%)
		HEAT repeat	91..118	CDD:293787	7/26 (27%)
		HEAT repeat	125..155	CDD:293787	11/29 (38%)
		HEAT repeat	164..190	CDD:293787	7/25 (28%)
		HEAT repeat	201..233	CDD:293787	8/31 (26%)