DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rb and apb-3

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_492170.2	Gene:	apb-3 / 172553	WormBaseID:	WBGene00000163	Length:	945	Species:	Caenorhabditis elegans

Alignment Length:	1150	Identity:	425/1150 - (36%)
Similarity:	601/1150 - (52%)	Gaps:	228/1150 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MSTYVE---RPQMGLDVEFGADPASGAAFFQSDGR-KHDDLKQMLDSNKDGLKLEAMKRIIGMIA 72
            |:::||   .|:|.:        |.|....  |.| :..|||.|||||||.||::||||||.:||
Worm     1 MTSFVEGLTSPEMEI--------AEGGVIL--DNRTRFADLKAMLDSNKDNLKVDAMKRIINLIA 55

  Fly    73 RGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASAL 137
            :|:|.|:||.||||||.:||:|:||||:|||||||||||||||||||||||||||||||||.|||
Worm    56 KGKDVSELFAAVVKNVAAKNVELKKLVFVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRGSAL 120

  Fly   138 RVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTT 202
            |||:||||.|:.||::|||:|:..|:||||||.|||||||||||:.:.:.:||..|:.||:||.:
Worm   121 RVLTSIRVPMVAPIMLLAIKDAVRDMSPYVRKVAAHAIPKLYSLEPELEPQLVDCIDFLLADRRS 185

  Fly   203 LVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDL 267
            ||:||||.||||:||.|:||:||::|.||..|.|||||||:::|||||||||.:..||:
Worm   186 LVLGSAVYAFDEICPHRLDLLHKHFRALCRGLADVDEWGQIVMINMLTRYARHELADPD------ 244

  Fly   268 VNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVD 332
                                                              |.|.        |.|
Worm   245 --------------------------------------------------RGPP--------DTD 251

  Fly   333 HRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMS 397
            ..|||...:|||||||.||||||.||::|||||.::..||:||:||||..:|.|.|||..||::.
Worm   252 VVLLLNSARPLLQSRNCSVVMAVVQLFYHVAPKAQLSQIARALVRLLRGPRETQYVVLTNIATIC 316

  Fly   398 TKR----------KAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSS 452
            .:.          |.:|:|.|||||||:.|.:.:|.|||.:||:|.|..::.:||||.|||:..|
Worm   317 ERNPVEEGTYAISKTMFDPFLKSFFVRSCDSSLVKKLKLHVLTSLVSEANVHIILRELQTYVHMS 381

  Fly   453 DRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIIT 517
            |  ..:..::||||||..:..|::.|::|||.|:|:.||.||..:||||||||...|.  ..:::
Worm   382 D--LASPAVEAIGRCAVRVGAVSDQCMTGLVQLISSSDEKVVCSAVVVIKRLLHASAP--LNLLS 442

  Fly   518 QMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLT 582
            ::.:|:..:....|||.:|||:..:.|:|..:|||.||.:||.|..|.::|||:.|.|.|||:|.
Worm   443 RLMRLMPNMIAAQARACVIWLVATHVEQVLHMAPDFLRLIAKKFSTENELVKLEALKLAVKLWLV 507

  Fly   583 NPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESK 647
            ..:.:..:.||||.|||:|.:||||||.||||.::|    .:.:||||..::|::.||||...|.
Worm   508 KRDDSEKIVQYVFQLARFDLSYDVRDRCRFLRNLMF----NTEILSQHMEEIFMSKKPAPELISS 568

  Fly   648 YRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGR 712
            :::.:.||||||||.||.....|.:||.||....||.:|..|          .:|:....|.|..
Worm   569 FKERDKFQLGSLSHVLNQRCTKYIDLPEFPATSSDSLLRKEA----------HAPNELKLDDSDE 623

  Fly   713 EGGKEKGAGGEKGFLSESDDKSSAYSESGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVS 777
            |              .:.||:.....|         .:.|.|.|   ..||||||.:.::..:..
Worm   624 E--------------EDDDDEDEEEDE---------DEEEEDED---EEDEEEEENESEEEEEDD 662

  Fly   778 SVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKN 842
            ..:|                             |...||.||........|:.....:.....|.
Worm   663 EDEE-----------------------------SEEESDEEDEEEEEEDDSEPEEKPNPKPSTKK 698

  Fly   843 ETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQA 907
            :......:||...|.|.|        :::||||:|:|               |...|:.
Worm   699 QALILNKSKPMNGKPKTE--------RNDLDLLIDVD---------------FSAAGSR------ 734

  Fly   908 APLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGE 972
                        :::..:|||.|..||||.:.|:||.|:..:   |.:......:|.....|:.:
Worm   735 ------------QIMDATHIEEKEIELLNVIEGNGLILSISY---PRINDGQYTAIRFGITNKTD 784

  Fly   973 KEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSR-LQL 1036
            .::..:.|   ....|:.:...:.|..:......|..|.|||.||..:.:..|....|..: .:.
Worm   785 GDLLGVEL---KTEEGLDVKGNSIIGDIPSGARVSVDLLVDFGDSATSREWILTRDDGHEKHFRF 846

  Fly  1037 KPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHSSS 1101
            :.|.||.|:.:::......:||::|.|:|.|             |:.|...:..| ::|...::.
Worm   847 EVPYGEQVQPIRLSPEDISKERSRLGGLNRH-------------VIQLENPINPS-SIALFVNAF 897

  Fly  1102 SGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMV 1146
            |..|..|..||.|.|.:.:||:..|:.:..     |:..|||.|:
Worm   898 SSDLTIFTCQTRSRKDVCILTVSEKSIECC-----CDNSVIGRML 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	296/591 (50%)
		HEAT repeat	48..73	CDD:293787	18/24 (75%)
		HEAT repeat	117..144	CDD:293787	24/26 (92%)
		Cnd1	129..>252	CDD:289487	80/122 (66%)
		HEAT repeat	147..179	CDD:293787	21/31 (68%)
		HEAT repeat	188..214	CDD:293787	15/25 (60%)
		AP3B1_C	881..1019	CDD:291462	27/137 (20%)
apb-3	NP_492170.2	Adaptin_N	23..546	CDD:279882	296/594 (50%)
		Motor_domain	<35..84	CDD:277568	34/48 (71%)
		HEAT repeat	100..128	CDD:293787	25/27 (93%)
		HEAT repeat	134..162	CDD:293787	19/27 (70%)
		HEAT repeat	171..197	CDD:293787	15/25 (60%)
		AP3B1_C	<740..826	CDD:291462	23/91 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166351
Domainoid	1	1.000	565	1.000	Domainoid score	I112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	660	1.000	Inparanoid score	I397
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	1	1.000	-	-		oto19770
orthoMCL	1	0.900	-	-		OOG6_101595
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2031
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930