Protein Alignment rb and AP2B1

DIOPT Version :9

• Sequence 1: NP_001162664.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: XP_011522750.1
• Gene: AP2B1 / 163
• HGNCID: 563
• Length: 983
• Species: Homo sapiens
• Alignment Length: 1011
• Identity: 253/1011 - (25%)
• Similarity: 412/1011 - (40%)
• Gaps: 269/1011 - (26%)

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|::.|...:.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Human    17 ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|::::::|.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Human    82 DMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..:..|::|...:||.:||.|..|:....     :||..:|..||...|
Human   147 KLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|:.|                                          ...||
Human   212 NECTEWGQIFILDCLSNY------------------------------------------NPKDD 234

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL---YHH 361
            .:.:|                               :..:..|.|...|::||::..::   :..
Human   235 REAQS-------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFLE 268

  Fly   362 VAPKNE------VQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTH 420
            :.||:.      ::.:|..|:.||....|||.|.|..|..:..||..|.:..:|.|||:.:||.:
Human   269 LLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY 333

  Fly   421 IKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHL 485
            :||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.|:.|
Human   334 VKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 398

  Fly   486 LSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIA 550
            :.....:||.|::|||:.:.:....::..||..:.:.:|.::.|.||||:||::|||.|::. .|
Human   399 IQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID-NA 462

  Fly   551 PDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRARFLR 614
            .::|....:.|.||...|:|.:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.....
Human   463 DELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYW 527

  Fly   615 QIIFPASGTSSVLSQHARQVFLASKP-----APVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674
            :::    .|..|.   |::|.|:.||     ..:.|....|.....:|||       |:.|.:
Human   528 RLL----STDPVT---AKEVVLSEKPLISEETDLIEPTLLDELICHIGSL-------ASVYHK-- 576

  Fly   675 AFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSE 739
                 ||::.|....|..:..||
Human   577 -----PPNAFVEGSHGIHRKHLP------------------------------------------ 594

  Fly   740 SGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINN 804
                ...|::|:.....|:.::...|      ||..:.|..:.|.|..:.:|   ..||
Human   595 ----IHHGSTDAGDSPVGTTTATNLE------QPQVIPSQGDLLGDLLNLDL---GPPV------ 640

  Fly   805 NNNARGSS----------GTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKH 859
             |..:.||          |..||...|...|......|.|.             ...|..:....
Human   641 -NVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQ-------------SFIPSSVPATF 691

  Fly   860 EKQPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGP 924
            ...|....|.|.|:.|.:|.    .|..|.|  ||::.|....
Human   692 APSPTPAVVSSGLNDLFELS----TGIGMAP--GGYVAPKAVW---------------------- 728

  Fly   925 SHIEFKHKELLNKVSGHGLHLAYRFT-RSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQT--- 983
                      |..|...||.::..|| |..|:|      :|:.|.|:..:.:|  ||:..:.
Human   729 ----------LPAVKAKGLEISGTFTHRQGHIY------MEMNFTNKALQHMTDFAIQFNKNSFG 777

  Fly   984 -----------------TLPAGMQLNEFAPITVLQP 1002
                             ::...:.||...|:..::|
Human   778 VIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEP 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	179/590 (30%)
		HEAT repeat	48..73	CDD:293787	8/24 (33%)
		HEAT repeat	117..144	CDD:293787	10/26 (38%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	7/27 (26%)
		AP3B1_C	881..1019	CDD:291462	25/145 (17%)
AP2B1	XP_011522750.1	Adaptin_N	11..534	CDD:307641	180/594 (30%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	7/25 (28%)
		HEAT repeat	197..228	CDD:293787	12/30 (40%)
		HEAT repeat	392..416	CDD:293787	9/23 (39%)
		HEAT repeat	428..457	CDD:293787	13/28 (46%)
		HEAT repeat	464..494	CDD:293787	10/29 (34%)
		HEAT repeat	505..541	CDD:293787	12/42 (29%)
		Alpha_adaptinC2	731..825	CDD:197886	18/89 (20%)
		B2-adapt-app_C	872..982	CDD:198088

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850