DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rb and AP1B1

DIOPT Version :9

Sequence 1:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster
Sequence 2:	NP_001118.3	Gene:	AP1B1 / 162	HGNCID:	554	Length:	949	Species:	Homo sapiens

Alignment Length:	1021	Identity:	269/1021 - (26%)
Similarity:	433/1021 - (42%)	Gaps:	258/1021 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|:|:|...|.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Human    17 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|:::::||.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Human    82 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..::.|:||...:||.:||.|..|:....     :||..::..||...|
Human   147 KLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|..|.                                          ..||
Human   212 NECTEWGQIFILDCLANYM------------------------------------------PKDD 234

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL------ 358
            .:.:|                               :..:..|.|...|::||::..::
Human   235 REAQS-------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFME 268

  Fly   359 -------YHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
                   |:....|.    :|..|:.||.:..|:|.|.|..|..:..||..|.:..:|.|||:.:
Human   269 MLSKDLDYYGTLLKK----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYN 329

  Fly   417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSG 481
            ||.::||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.
Human   330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394

  Fly   482 LVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKV 546
            |:.|:.....:||.|::||||.:.:....::..:|..:.:.:|.::.|.||||:||::|||.|::
Human   395 LLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERI 459

  Fly   547 PLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRA 610
            . .|.::|....:.|.||...|:||:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.
Human   460 D-NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRG 523

  Fly   611 RFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPA 675
            ....:::    .|..|.   |::|.||.||....|:...:..  .|..|..|:...|:.|.:
Human   524 YIYWRLL----STDPVA---AKEVVLAEKPLISEETDLIEPT--LLDELICYIGTLASVYHK--- 576

  Fly   676 FPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSES 740
                ||.:.|                           |||        :|.:.:|....:|.|||
Human   577 ----PPSAFV---------------------------EGG--------RGVVHKSLPPRTASSES 602

  Fly   741 GSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNN 805
            ..|         .::..:|:...|:.:|...|...:..:..  :|.|    ...|.|..||
Human   603 AES---------PETAPTGAPPGEQPDVIPAQGDLLGDLLN--LDLG----PPVSGPPLAT---- 648

  Fly   806 NNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKS 870
                          ||...| :.|....|.|:.:         |.:||.:...:...|...||.:
Human   649 --------------SSVQMG-AVDLLGGGLDSLM---------GDEPEGIGGTNFVAPPTAAVPA 689

  Fly   871 NLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELL 935
            ||.        .|||..::....  ||.|...::|              ..|.|..:      .|
Human   690 NLG--------APIGSGLSDLFD--LTSGVGTLSG--------------SYVAPKAV------WL 724

  Fly   936 NKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQTTL---PAGMQLNEFA 995
            ..:...||.::..|||     .....|::||..|:..:.:|  ||:..:.:.   ||       |
Human   725 PAMKAKGLEISGTFTR-----QVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPA-------A 777

  Fly   996 PITV---LQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKP 1038
            |:.|   |.|.||               |::.|..|...|.::::|
Human   778 PLQVHAPLSPNQT---------------VEISLPLSTVGSVMKMEP 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	182/594 (31%)
		HEAT repeat	48..73	CDD:293787	10/24 (42%)
		HEAT repeat	117..144	CDD:293787	11/26 (42%)
		Cnd1	129..>252	CDD:289487	44/129 (34%)
		HEAT repeat	147..179	CDD:293787	12/31 (39%)
		HEAT repeat	188..214	CDD:293787	8/27 (30%)
		AP3B1_C	881..1019	CDD:291462	31/145 (21%)
AP1B1	NP_001118.3	Adaptin_N	11..534	CDD:396262	183/598 (31%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	11/26 (42%)
		HEAT repeat	121..151	CDD:293787	12/29 (41%)
		HEAT repeat	160..186	CDD:293787	8/25 (32%)
		HEAT repeat	197..228	CDD:293787	11/30 (37%)
		HEAT repeat	355..379	CDD:293787	8/23 (35%)
		HEAT repeat	391..419	CDD:293787	11/27 (41%)
		HEAT repeat	427..458	CDD:293787	12/30 (40%)
		HEAT repeat	464..490	CDD:293787	8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		12/57 (21%)
		Alpha_adaptinC2	726..826	CDD:197886	26/110 (24%)
		B2-adapt-app_C	835..948	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920