Protein Alignment rb and Ap3b2

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: XP_006540634.1
• Gene: Ap3b2 / 11775
• MGIID: 1100869
• Length: 1101
• Species: Mus musculus
• Alignment Length: 1174
• Identity: 604/1174 - (51%)
• Similarity: 765/1174 - (65%)
• Gaps: 140/1174 - (11%)

  Fly    26 EFGADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVS 90
            |:|.||||| ..|.||.::|||||:|||:|||.|||||||||:.|||||::||||||||||||..
Mouse    21 EYGHDPASG-GIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVAC 84

  Fly    91 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLA 155
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||.:||||:|||
Mouse    85 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLA 149

  Fly   156 IRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERV 220
            |:::|:|:|||||||||||||||||||:||||:|:.||||||:|:||||.||.||||:||||||:
Mouse   150 IKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERI 214

  Fly   221 DLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDES 285
            ||||||||||||.|:||:|||||:||:||||||||||:.|..      |:.|.|....:.||
Mouse   215 DLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQ------NESLLEENPEKAFY--- 270

  Fly   286 SHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNS-YHIDVDHRLLLRQTKPLLQSRNA 349
                     ||.:||        ....|...:.|.:.|:.. |.:|.|||||||.||||||||:|
Mouse   271 ---------GSEEDE--------AKGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSA 318

  Fly   350 SVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVR 414
            :|||||||||.|:|||.||.:|||||:||||||.|||.|||..:|:||.||:.:|||:||||::|
Mouse   319 AVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIR 383

  Fly   415 TSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCL 479
            ::|||.||:|||::|||||:..:|..:||||||||.|.|:.|||||||||||||::|..|.:|||
Mouse   384 STDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCL 448

  Fly   480 SGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNE 544
            :|||.||||.||.||||||||||:|||.:.|:|.|||..:|||.|.|.||.|||:|:||||||.|
Mouse   449 NGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513

  Fly   545 KVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDR 609
            .||.|||||||||||||..|:|:|||||:||..||||||.:||.||.|||.:||:||.|||:|||
Mouse   514 HVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDR 578

  Fly   610 ARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674
            |||.||:|.| |.....||:||:::|||.||||:.||.::|.::||||||||.||..|.||:|||
Mouse   579 ARFTRQLIVP-SEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQLGSLSHLLNAKATGYQELP 642

  Fly   675 AFPVIPPDSSVRNI-----------AGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLS 728
            .:|...||.||||:           .|.:     ||.:........|.||..|||    ||.|.|
Mouse   643 DWPEEAPDPSVRNVEEEDLSLIETHVGLL-----GEYTEVPEWTKCSNREKRKEK----EKPFYS 698

  Fly   729 ------------ESDDKSSAYSESGSSSGSGTSDSESDSD--------GSGS-SDEEEEEVQKQQ 772
                        :|:.:|.:.|||.||||||:.:|.|:||        |.|| |::.|||.:|::
Mouse   699 DSEGESGPTESADSEPESESESESKSSSGSGSGESSSESDNEEEDEEKGGGSESEQSEEEDEKKK 763

  Fly   773 PTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDN 837
            .||.....|     |..|                   |||    ||:.|        ||:|.|::
Mouse   764 KTKKKKASE-----GHRE-------------------GSS----SEEGS--------DSSSSSES 792

  Fly   838 EVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDD-----IPPIGP--VMTPSLGGF 895
            ||.....:..  .:|...::|.....:...|...:. ||||:|     :.|:.|  |::.||...
Mouse   793 EVTSESEEEQ--VEPASWRKKTPPGSKSAPVAKEIS-LLDLEDFTPPSVQPVSPPMVVSTSLAAD 854

  Fly   896 LTPGTPMMAGQAAP--LQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSS 958
            | .|..:......|  |.|      |..:|       .:|||::|:|.||.:.|.|:|.|.....
Mouse   855 L-EGLTLTDSSLVPSLLSP------VSSIG-------RQELLHRVAGEGLSVDYAFSRQPFSGDP 905

  Fly   959 SMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDL 1023
            .|.|:.:.|.|..|..|..:.:|...||||:.:.||..|..|.|.::.:.|:|::|.|||.|.:.
Mouse   906 HMVSLHIYFSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQAANF 970

  Fly  1024 ELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELR---GLRQDLIDVVALR 1085
            :|.:......:.::||||||:..|.:.|:..::|:.||.||||...:|.   ..|.|.:.|
Mouse   971 QLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVV---- 1031

  Fly  1086 QKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNEL 1150
            |||..:.|:......:|.: :.|||:||:|.||||||||.:...|..|.||.||||||:|::.::
Mouse  1032 QKVTATANLGRVPCGTSDE-YRFAGRTLTSGSLVLLTLDARAAGAAQLTVNSEKMVIGTMLVKDV 1095

  Fly  1151 RNAL 1154
            ..||
Mouse  1096 IQAL 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	399/581 (69%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	25/26 (96%)
		HEAT repeat	147..179	CDD:293787	24/31 (77%)
		HEAT repeat	188..214	CDD:293787	18/25 (72%)
		AP3B1_C	881..1019	CDD:464319	44/141 (31%)
Ap3b2	XP_006540634.1	Adaptin_N	34..590	CDD:396262	399/582 (69%)
		HEAT repeat	111..139	CDD:293787	26/27 (96%)
		HEAT repeat	145..173	CDD:293787	21/27 (78%)
		HEAT repeat	182..208	CDD:293787	18/25 (72%)
		AP3B1_C	823..966	CDD:464319	49/157 (31%)