Protein Alignment rb and Ap3b1

DIOPT Version :10

• Sequence 1: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: XP_006517586.1
• Gene: Ap3b1 / 11774
• MGIID: 1333879
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 586/1201 - (48%)
• Similarity: 772/1201 - (64%)
• Gaps: 139/1201 - (11%)

  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64
            :||.||   |.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
Mouse     2 SSNSFA---YNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAM 63

  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
Mouse    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128

  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194
            ||||||||||||||||.:|||::||||::::|||||||||.|||||.||||||.:||:.|:.|||
Mouse   129 QLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193

  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259
            |||.|::|||.||.||||:||||:|:||||:|||||||.|:||:|||||:||:|||||||||||.
Mouse   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258

  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324
            |..:|..|.::       .:.||:..          ..::||.|||.                 .
Mouse   259 PWREDGGLEDN-------EKNFYESE----------EEEEEKEKSSR-----------------K 289

  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389
            .||.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
Mouse   290 KSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGVISKSLVRLLRSNREVQYIV 354

  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
Mouse   355 LQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDK 419

  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519
            .|.|||||.|||||:||.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
Mouse   420 QFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIRHM 484

  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:|||..||||||.
Mouse   485 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAAKLYLTNS 549

  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
Mouse   550 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NEKSGALSKYAKKIFLAPKPAPLLESPFK 613

  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714
            |.:.||||:|||.||:.|:||.||..:|.:.||.||||:......|   |.:|.|.:|
Mouse   614 DRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAK---EWTPLGKTK------- 668

  Fly   715 GKEKGAGGEKGFLSESDDK-----------------------SSAYSESGSSSGSGTSDSESDSD 756
             |||..   |.|.|||:::                       ||:.|||||.|.||.:.:|..|:
Mouse   669 -KEKPM---KKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSE 729

  Fly   757 GSGSSDEEE----EEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDS 817
            .|.|..:.|    .|.::|:..|.:|..:|..|:.:.|            ..|.|::.|.  |.|
Mouse   730 DSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENRE------------KKNENSKASE--SSS 780

  Fly   818 EDSSAYSGSSSD-DSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDD 880
            |:||:...|||: :|.||||:|           ..|..:....|::|:|.....:.|: ||||||
Mouse   781 EESSSMEDSSSESESESGSDSE-----------PAPRNVAPAKERKPQQERHPPSKDVFLLDLDD 834

  Fly   881 IPPIG-PVMTPSLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGL 943
            ..|:. ||..|      ||. :|.:......|....:.:.:.:..|..:..|..|||:::.|.||
Mouse   835 FNPVSTPVALP------TPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGL 893

  Fly   944 HLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASG 1008
            ...|.|.|.|.::|..|.|:::...|..:::|..|.:|...||.|||::.|.||..|:|:.:.:.
Mouse   894 AAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTV 958

  Fly  1009 VLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERA-------------K 1060
            .:|:||.|||.....:|.:......:.|:||||||:..|.:.|...::|:|             .
Mouse   959 SVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGT 1023

  Fly  1061 LRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHS--SSSGQLHCFAGQTLSSKSLVLLTL 1123
            |.||||....|....|:....:.| |||   :|||:..:  ||...:|.||.:|:.|.||:|:|:
Mouse  1024 LTGMNETSATLIAAPQNFTPSMIL-QKV---VNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTV 1084

  Fly  1124 DWKTEDALTLLVNCEKMVIGSMVLNELRNAL 1154
            :.|......|::|.||.||||::|.||:..|
Mouse  1085 ELKEGSTAQLIINTEKTVIGSVLLRELKPVL 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	384/580 (66%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	26/26 (100%)
		HEAT repeat	147..179	CDD:293787	22/31 (71%)
		HEAT repeat	188..214	CDD:293787	17/25 (68%)
		AP3B1_C	881..1019	CDD:464319	42/139 (30%)
Ap3b1	XP_006517586.1	Adaptin_N	46..582	CDD:396262	379/569 (67%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		HEAT repeat	150..180	CDD:293787	21/29 (72%)
		HEAT repeat	188..213	CDD:293787	17/24 (71%)
		SEEEED	<734..792	CDD:434218	18/71 (25%)
		AP3B1_C	824..969	CDD:464319	49/150 (33%)