DRSC/TRiP Functional Genomics Resources

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Protein Alignment rb and Ap3b1

DIOPT Version :9

Sequence 1:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster
Sequence 2:XP_006517586.1 Gene:Ap3b1 / 11774 MGIID:1333879 Length:1118 Species:Mus musculus


Alignment Length:1201 Identity:586/1201 - (48%)
Similarity:772/1201 - (64%) Gaps:139/1201 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64
            :||.||   |.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
Mouse     2 SSNSFA---YNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAM 63

  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
Mouse    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128

  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194
            ||||||||||||||||.:|||::||||::::|||||||||.|||||.||||||.:||:.|:.|||
Mouse   129 QLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193

  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259
            |||.|::|||.||.||||:||||:|:||||:|||||||.|:||:|||||:||:|||||||||||.
Mouse   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258

  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324
            |..:|..|.::       .:.||:..          ..::||.|||.                 .
Mouse   259 PWREDGGLEDN-------EKNFYESE----------EEEEEKEKSSR-----------------K 289

  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389
            .||.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
Mouse   290 KSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGVISKSLVRLLRSNREVQYIV 354

  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
Mouse   355 LQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDK 419

  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519
            .|.|||||.|||||:||.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
Mouse   420 QFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIRHM 484

  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:|||..||||||.
Mouse   485 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAAKLYLTNS 549

  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
Mouse   550 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NEKSGALSKYAKKIFLAPKPAPLLESPFK 613

  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714
            |.:.||||:|||.||:.|:||.||..:|.:.||.||||:......|   |.:|.|.:|       
Mouse   614 DRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAK---EWTPLGKTK------- 668

  Fly   715 GKEKGAGGEKGFLSESDDK-----------------------SSAYSESGSSSGSGTSDSESDSD 756
             |||..   |.|.|||:::                       ||:.|||||.|.||.:.:|..|:
Mouse   669 -KEKPM---KKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSE 729

  Fly   757 GSGSSDEEE----EEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDS 817
            .|.|..:.|    .|.::|:..|.:|..:|..|:.:.|            ..|.|::.|.  |.|
Mouse   730 DSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENRE------------KKNENSKASE--SSS 780

  Fly   818 EDSSAYSGSSSD-DSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDD 880
            |:||:...|||: :|.||||:|           ..|..:....|::|:|.....:.|: ||||||
Mouse   781 EESSSMEDSSSESESESGSDSE-----------PAPRNVAPAKERKPQQERHPPSKDVFLLDLDD 834

  Fly   881 IPPIG-PVMTPSLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGL 943
            ..|:. ||..|      ||. :|.:......|....:.:.:.:..|..:..|..|||:::.|.||
Mouse   835 FNPVSTPVALP------TPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGL 893

  Fly   944 HLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASG 1008
            ...|.|.|.|.::|..|.|:::...|..:::|..|.:|...||.|||::.|.||..|:|:.:.:.
Mouse   894 AAHYCFPRQPCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTV 958

  Fly  1009 VLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERA-------------K 1060
            .:|:||.|||.....:|.:......:.|:||||||:..|.:.|...::|:|             .
Mouse   959 SVGIDFCDSTQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGT 1023

  Fly  1061 LRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHS--SSSGQLHCFAGQTLSSKSLVLLTL 1123
            |.||||....|....|:....:.| |||   :|||:..:  ||...:|.||.:|:.|.||:|:|:
Mouse  1024 LTGMNETSATLIAAPQNFTPSMIL-QKV---VNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTV 1084

  Fly  1124 DWKTEDALTLLVNCEKMVIGSMVLNELRNAL 1154
            :.|......|::|.||.||||::|.||:..|
Mouse  1085 ELKEGSTAQLIINTEKTVIGSVLLRELKPVL 1115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 384/580 (66%)
HEAT repeat 48..73 CDD:293787 19/24 (79%)
HEAT repeat 117..144 CDD:293787 26/26 (100%)
Cnd1 129..>252 CDD:289487 92/122 (75%)
HEAT repeat 147..179 CDD:293787 22/31 (71%)
HEAT repeat 188..214 CDD:293787 17/25 (68%)
AP3B1_C 881..1019 CDD:291462 42/139 (30%)
Ap3b1XP_006517586.1 Adaptin_N 46..582 CDD:366724 379/569 (67%)
HEAT repeat 116..144 CDD:293787 27/27 (100%)
HEAT repeat 150..180 CDD:293787 21/29 (72%)
HEAT repeat 188..213 CDD:293787 17/24 (71%)
SEEEED <734..812 CDD:373302 26/102 (25%)
AP3B1_C 824..969 CDD:373301 49/150 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833471
Domainoid 1 1.000 757 1.000 Domainoid score I87
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68125
Inparanoid 1 1.050 1003 1.000 Inparanoid score I293
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54550
OrthoDB 1 1.010 - - D147356at33208
OrthoFinder 1 1.000 - - FOG0002006
OrthoInspector 1 1.000 - - otm43466
orthoMCL 1 0.900 - - OOG6_101595
Panther 1 1.100 - - LDO PTHR11134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2031
SonicParanoid 1 1.000 - - X1748
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.940

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