DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rb and Ap1b1

DIOPT Version :9

Sequence 1:NP_001162664.2 Gene:rb / 31381 FlyBaseID:FBgn0003210 Length:1160 Species:Drosophila melanogaster
Sequence 2:NP_001229972.1 Gene:Ap1b1 / 11764 MGIID:1096368 Length:953 Species:Mus musculus


Alignment Length:1030 Identity:269/1030 - (26%)
Similarity:431/1030 - (41%) Gaps:272/1030 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 DLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQ 111
            :||..|:|:|...|.||:|::|..:..|:|.|.|||.||..:.:.|:|:|||||:||:.||:.|.
Mouse    17 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81

  Fly   112 DLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIP 176
            |:|:::::||.:..:|||.||||.|:|.:..|||..|...:...:|....|..||||||||..:.
Mouse    82 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA 146

  Fly   177 KLYSLDADQKDE--LVMVIEKLLSDRTTLVVGSAVMAFDEVCPER-----VDLIHKNYRKLCNFL 234
            ||:.::|...::  .:..::.|:||...:||.:||.|..|:....     :||..::..||...|
Mouse   147 KLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTAL 211

  Fly   235 LDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDD 299
            .:..||||:.|::.|..|.                                          ..||
Mouse   212 NECTEWGQIFILDCLANYM------------------------------------------PKDD 234

  Fly   300 EKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQL------ 358
            .:.:|                               :..:..|.|...|::||::..::      
Mouse   235 REAQS-------------------------------ICERVTPRLSHANSAVVLSAVKVLMKFME 268

  Fly   359 -------YHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
                   |:....|.    :|..|:.||.:..|:|.|.|..|..:..||..|.:..:|.|||:.:
Mouse   269 MLSKDLDYYATLLKK----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYN 329

  Fly   417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSG 481
            ||.::||.||||:..|||..:|:.:|.|.:.|.:..|..||...::||||||..:::..|.|:|.
Mouse   330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394

  Fly   482 LVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKV 546
            |:.|:.....:||.|::||||.:.:....::..:|..:.:.:|.::.|.||||:||::|||.|::
Mouse   395 LLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERI 459

  Fly   547 PLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYD-PNYDVRDRA 610
            . .|.::|....:.|.||...|:||:|...|||:|..|.:|..|.|.|.:||..| .|.|:|||.
Mouse   460 D-NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRG 523

  Fly   611 RFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPA 675
            ....:::    .|..|.   |::|.||.||....|:...:..  .|..|..|:...|:.|.:   
Mouse   524 YIYWRLL----STDPVA---AKEVVLAEKPLISEETDLIEPT--LLDELICYIGTLASVYHK--- 576

  Fly   676 FPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSES 740
                ||::.|                           |||        :|.:.:|....:|.|||
Mouse   577 ----PPNAFV---------------------------EGG--------RGVVHKSLPPRTASSES 602

  Fly   741 GSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERL-----IDAG----SNELAATSS 796
                   |...|:...|:.:.|         ||..:.:..:.|     :|.|    ...|||:|.
Mouse   603 -------TESPETAPAGAPAGD---------QPDVIPAQGDLLGDLLNLDLGPPVSGPPLAASSV 651

  Fly   797 PVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEK 861
            .:.|.     :..|....|...|.|...|.|:..:.|.|          ......|.:|      
Mouse   652 QMGAV-----DLLGGGLDSLMGDESEGIGDSNFGAPSAS----------VAAAPAPARL------ 695

  Fly   862 QPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSH 926
               ...:.|.|..|.|                  ||.|...::|              ..|.|..
Mouse   696 ---GAPISSGLSDLFD------------------LTSGVGTLSG--------------SYVAPKA 725

  Fly   927 IEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEIT--AIRLGQTTL---P 986
            :      .|..:...||.::..|||     .:...|::||..|:..:.:|  ||:..:.:.   |
Mouse   726 V------WLPAMKAKGLEISGTFTR-----QAGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAP 779

  Fly   987 AGMQLNEFAPITV---LQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKP 1038
            |       ||:.|   |.|.||               |::.|..:...|.|:::|
Mouse   780 A-------APLQVHVPLSPNQT---------------VEISLPLNTVGSVLKMEP 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rbNP_001162664.2 Adaptin_N 40..621 CDD:279882 182/594 (31%)
HEAT repeat 48..73 CDD:293787 10/24 (42%)
HEAT repeat 117..144 CDD:293787 11/26 (42%)
Cnd1 129..>252 CDD:289487 44/129 (34%)
HEAT repeat 147..179 CDD:293787 12/31 (39%)
HEAT repeat 188..214 CDD:293787 8/27 (30%)
AP3B1_C 881..1019 CDD:291462 28/145 (19%)
Ap1b1NP_001229972.1 Adaptin_N 11..534 CDD:366724 183/598 (31%)
HEAT repeat 51..75 CDD:293787 13/23 (57%)
HEAT repeat 87..114 CDD:293787 11/26 (42%)
HEAT repeat 121..151 CDD:293787 12/29 (41%)
HEAT repeat 160..186 CDD:293787 8/25 (32%)
HEAT repeat 197..228 CDD:293787 11/30 (37%)
HEAT repeat 355..379 CDD:293787 8/23 (35%)
HEAT repeat 391..419 CDD:293787 11/27 (41%)
HEAT repeat 427..458 CDD:293787 12/30 (40%)
HEAT repeat 464..490 CDD:293787 8/25 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..621 14/60 (23%)
Alpha_adaptinC2 730..830 CDD:197886 26/110 (24%)
B2-adapt-app_C 839..952 CDD:198088
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323029at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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