Protein Alignment rb and ap3b1

DIOPT Version :9

• Sequence 1: NP_001162664.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Sequence 2: XP_012822818.3
• Gene: ap3b1 / 100493180
• XenbaseID: XB-GENE-987208
• Length: 1097
• Species: Xenopus tropicalis
• Alignment Length: 1129
• Identity: 552/1129 - (48%)
• Similarity: 748/1129 - (66%)
• Gaps: 76/1129 - (6%)

  Fly    28 GADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKN 92
            |....|....|.:|.:|::||||||:||||..||||||||:|||:.|::||:|||||||||.|||
 Frog    40 GNSTPSVFGLFSTDLKKNEDLKQMLESNKDSSKLEAMKRIVGMISDGKNASELFPAVVKNVASKN 104

  Fly    93 IEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIR 157
            :|:|||||||||||||||||||||||:||||.|||||||||||||||||||||.:||||:||||:
 Frog   105 LEIKKLVYVYLVRYAEEQQDLALLSIATFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIK 169

  Fly   158 DSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDL 222
            ::||||||||||||||||.||||||.:|||.|:.||||||.|::|||.||.||||:||||:|:||
 Frog   170 EAAADLSPYVRKTAAHAIQKLYSLDPEQKDMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDL 234

  Fly   223 IHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSH 287
            ||||||||||.|:||:|||||:||:|||||||.|||.|..::.|     .||. .::.||:
 Frog   235 IHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARMQFVSPWVEEGD-----SGEM-TTQSFYE---- 289

  Fly   288 SSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVV 352
                     ||:||: :.||.|               ..|.:|.|||||||.||||||||||:||
 Frog   290 ---------SDEEKD-ADTNQK---------------RPYVMDPDHRLLLRNTKPLLQSRNAAVV 329

  Fly   353 MAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSD 417
            |||||||.|:|||:|...:||:||||||||:|||.:||..||::|.:||.:|||:||||::|::|
 Frog   330 MAVAQLYWHLAPKSETSTVAKSLIRLLRSHREVQYIVLQNIATISIQRKGLFEPYLKSFYIRSTD 394

  Fly   418 PTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGL 482
            ||.||.|||:|:||||:..::|.:|||||||:.|.|:.|.|||||||||||::|..||:|||:||
 Frog   395 PTMIKTLKLEIMTNLANEANVSTLLREFQTYVRSQDKQFAAATIQAIGRCATNISAVTDTCLNGL 459

  Fly   483 VHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVP 547
            |.||||.|:.||||||||||:||||:.:.|.:||..||||.|.|.||.|||:|:||||||.|:||
 Frog   460 VLLLSNRDDVVVAESVVVIKKLLQTQTSHHSDIIRHMAKLFDKITVPMARASILWLIGEYCERVP 524

  Fly   548 LIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDRARF 612
            .||||||||.||||.:|.|:||||::||.|||:|||.:||.||.||:..|.:||.|||:|||.||
 Frog   525 KIAPDVLRKTAKSFTNEDDLVKLQIINLAVKLFLTNSKQTKLLAQYILNLGKYDQNYDIRDRTRF 589

  Fly   613 LRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFP 677
            ::|:|.| :..|..||::|:::|||.|||||.:|.::|..:||||:|||.||..|:||.||..:|
 Frog   590 VKQLIVP-NEKSGALSKYAKKIFLAQKPAPVLKSSFKDREHFQLGTLSHSLNTKASGYLELSDWP 653

  Fly   678 VIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESGS 742
            .|.||.||||:            .||...|:|:    .|::.|..||     |.||..:.||.|.
 Frog   654 EIAPDPSVRNV------------EPSEPVKNKA----TKQEMANTEK-----SSDKFYSDSEEGE 697

  Fly   743 SSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNN 807
            .....:|::||:|:  ..||.|:|...:|.....|:..|...|..|      |...|....::.:
 Frog   698 KESEESSENESESE--EDSDNEKESSSEQSDASSSAESESESDESS------SKEQKNRKKDSED 754

  Fly   808 ARGSSGTSDSEDSSAYSGSSSDDSASGSDNE-VKKNETKTDTGTKPEKLKEKHEKQPEQTAV-KS 870
            .:..:||. |||||.||..||:.::|.|.:| .:::|::.:|..|....|:...|..:|..: :.
 Frog   755 EKKGTGTK-SEDSSVYSEDSSESASSESSSESEEESESEPETSKKVTNSKKTENKPVKQKEIPRK 818

  Fly   871 NLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELL 935
            |...||||||......|..||:      .:|.:......|....:...:.:..||.:..|..|||
 Frog   819 NEVSLLDLDDFNMPAAVAKPSI------LSPSLLSDLEGLSLSSSSPVINVCTPSFVPSKTHELL 877

  Fly   936 NKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVL 1000
            :::||.||...|.|.|...::.:.|.::::.|.|..:|.|..|.:.:..:.||::::.|..|..|
 Frog   878 HRMSGKGLAAQYHFPRQQCIFGAQMVTVQITFNNTTDKRIEDIHIEEKKMAAGVKMHAFNQIDYL 942

  Fly  1001 QPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMN 1065
            :|:.:.:..:|:||.|||.....:|.:......:.::||.|||:..|.:.|:..::|:.||.|||
 Frog   943 EPEGSITVSMGIDFCDSTQTASFQLCTKENQFSVGIQPPPGELLLPVSLSEADFKKEQGKLTGMN 1007

  Fly  1066 EHQCELRGLRQDLIDVVALRQKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDA 1130
            |....: .:..:......:.|:..::.|:. ..:|....::.||.:|:.|.||:|:|::.|...|
 Frog  1008 ESSATI-AVNAEYSTPQIIGQRFLQAANLG-VVASGQNNIYRFAAKTVHSGSLMLVTVELKGGSA 1070

  Fly  1131 LTLLVNCEKMVIGSMVLNELRNAL 1154
            ..|::|.||.||||::|.||:..|
 Frog  1071 AQLIINTEKTVIGSVLLRELKPVL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	381/580 (66%)
		HEAT repeat	48..73	CDD:293787	20/24 (83%)
		HEAT repeat	117..144	CDD:293787	24/26 (92%)
		Cnd1	129..>252	CDD:289487	97/122 (80%)
		HEAT repeat	147..179	CDD:293787	25/31 (81%)
		HEAT repeat	188..214	CDD:293787	17/25 (68%)
		AP3B1_C	881..1019	CDD:291462	35/137 (26%)
ap3b1	XP_012822818.3	Adaptin_N	59..594	CDD:396262	377/569 (66%)
		HEAT repeat	129..157	CDD:293787	25/27 (93%)
		HEAT repeat	163..193	CDD:293787	24/29 (83%)
		HEAT repeat	201..226	CDD:293787	17/24 (71%)
		AP3B1_C	818..961	CDD:405483	42/148 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	769	1.000	Domainoid score	I86
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1011	1.000	Inparanoid score	I290
OMA	1	1.010	-	-		QHG54550
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	1	1.000	-	-		otm48621
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080