DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3556 and TCN1

DIOPT Version :9

Sequence 1:NP_001245529.1 Gene:CG3556 / 31380 FlyBaseID:FBgn0029708 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_001053.2 Gene:TCN1 / 6947 HGNCID:11652 Length:433 Species:Homo sapiens


Alignment Length:447 Identity:87/447 - (19%)
Similarity:165/447 - (36%) Gaps:106/447 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 EAILRALDWLKEKRASDYGWGNDTHVVILAKELSGGRDPNDSVDGHVQVIQELEDTLSVKEMEIE 230
            :.:::.:.:..:.|.||...| :..::|||..:....:.|...|.|  :|.:||:..   :.|||
Human    73 QKMIQQIKYNVKSRLSDVSSG-ELALIILALGVCRNAEENLIYDYH--LIDKLENKF---QAEIE 131

  Fly   231 ILAMLDRHHTLP----KPLDLDKLARYVLALGSLCKDPKHFHGHDLVATLQHHEPAQDIEFALTT 291
               .::.|:..|    ..|.||.||        ||.    |:|:...|.:.:|...::..:... 
Human   132 ---NMEAHNGTPLTNYYQLSLDVLA--------LCL----FNGNYSTAEVVNHFTPENKNYYFG- 180

  Fly   292 LSACSSAAHVRKRQIRRLLDIASGVTDQSVDAIAMVILALRCI----------VTDHRHRHLQHF 346
                                     :..|||..||.:|||.|:          ..:...:::..:
Human   181 -------------------------SQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIY 220

  Fly   347 VRRPARGLATLQDQRGSFGSLRSTALAMQAL-QDLEYDPAGHWNRTAASRYILSRQRADGGWSEE 410
            .:.....:.:.:.:.|..|:..||..||||| ...:|.....||.......:|: :.:.|.:|..
Human   221 TKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLT-EISQGAFSNP 284

  Fly   411 PLQDGQEPDIGVGLTADIILALGWKGLGAVRALQCDHVIRESSDPTENGEPKLAVPFGLSSSAEE 475
                        ...|.::.||..|....:.        ::||..:.:|...::....::.:..:
Human   285 ------------NAAAQVLPALMGKTFLDIN--------KDSSCVSASGNFNISADEPITVTPPD 329

  Fly   476 SDAKNISYTYTLWVGSNVTESFSLSLVSPKNTSFFKAMTQAAEMDPR---FIFEAREWPNGHYVH 537
            |.: .||..|::    .:.|::..::.....:.|...|.:|.:|:..   |..|.|.|  |.|:.
Human   330 SQS-YISVNYSV----RINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSW--GPYIT 387

  Fly   538 TLYGKKEEPRGYHYWLLYRLPELPDPNNTPGNQLIAPVGVDELMVEDGEHY-LYWYK 593
            .:.|.........||.|.       ....|.:|     |....:|.:||:. :.|.|
Human   388 CIQGLCANNNDRTYWELL-------SGGEPLSQ-----GAGSYVVRNGENLEVRWSK 432

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG3556NP_001245529.1 ISOPREN_C2_like 165..411 CDD:298658 53/259 (20%)
TCN1NP_001053.2 Cobalamin_bind 24..327 CDD:279466 60/321 (19%)
Globular N-terminal alpha domain 24..310 59/304 (19%)
Cyanocob(III)alamin binding. /evidence=ECO:0000269|PubMed:23846701, ECO:0007744|PDB:4KKI 142..146 0/3 (0%)
Flexible linker 311..332 2/20 (10%)
Globular C-terminal beta domain 333..433 26/118 (22%)
DUF4430 356..432 CDD:291166 21/89 (24%)