DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and TBX3

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_057653.3	Gene:	TBX3 / 6926	HGNCID:	11602	Length:	743	Species:	Homo sapiens

Alignment Length:	838	Identity:	309/838 - (36%)
Similarity:	394/838 - (47%)	Gaps:	233/838 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 SHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPA 259
            ::||...|.:|....:|.               |..|           ||:|||..|.. .|:.|
Human    16 AYHPFLPHRAPDFAMSAV---------------LGHQ-----------PPFFPALTLPP-NGAAA 53

  Fly   260 GPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGV 324
            ...||..             |.|....|..|   ||..:..|::..|.|  :|||:.::||:: |
Human    54 LSLPGAL-------------AKPIMDQLVGA---AETGIPFSSLGPQAH--LRPLKTMEPEEE-V 99

  Fly   325 VDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYK 389
            .|||||.||.|:||::|||.|||||||||||:|||..|.|.||||.|||||||:||:||||.|||
Human   100 EDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYK 164

  Fly   390 FHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFV--------- 445
            |||||||||||||||||||||||||||.||||||.|||:||||||||||||||||.
Human   165 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHAT 229

  Fly   446 --------STTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKI 502
                    :.||||||||||||||:|||||||||||||||||:|.||||||||||||:|||||||
Human   230 WQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKI 294

  Fly   503 DNNPFAKGFRDTGAGKREKKQ--ALMSNRGSDS--DKLNPT--HVSSSRAPLH-LGHAGRP---- 556
            |||||||||||||.|:|||::  .|.|.|..|.  .|.|.|  ..||.:|..: ...|..|
Human   295 DNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAAST 359

  Fly   557 ------PHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQ----------MHAH----- 600
                  ..|.|.    :.:.|.:.:..:..||.......:|.:..:          :.||
Human   360 VGTSNLKDLCPS----EGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE 420

  Fly   601 ---------------QHSAALAAWFNHLAGAGAGASEHAA---AAAANASAEDALRRRLQ----- 642
                           :||.|..:    .:..|.||.|..:   ...|.|..|:|  |.|.
Human   421 RPRDSGRLDKASPDSRHSPATIS----SSTRGLGAEERRSPVREGTAPAKVEEA--RALPGKEAF 479

  Fly   643 ADADVERDGSDSSCSE----------SVGG----------------STGGAFRP----------- 670
            |...|:.|.:.:..::          .:.|                :.||||..
Human   480 APLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMGPLLA 544

  Fly   671 ----TSTG-SPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLP----YLYPHG-LY 725
                .||| |..::...|:||||.||:  |.|      :...|.|...|:|.    .:.|.| |:
Human   545 TVSGASTGVSGLDSTAMASAAAAQGLS--GAS------AATLPFHLQQHVLASQGLAMSPFGSLF 601

  Fly   726 PPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRF 790
            |.|:..:    |||||.|.|..:..:..:..|.|....|.|                      |:
Human   602 PYPYTYM----AAAAAASSAAASSSVHRHPFLNLNTMRPRL----------------------RY 640

  Fly   791 SPYSLPGSLGSAFDAVTPGSNANRSGDPP-GGGGGGLGGGV--VENGPRSLSSSPRPRPASHSPP 852
            ||||:|       ..|..||:...:..|. ....|.|.|.|  :...|.|::........|.|..
Human   641 SPYSIP-------VPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSST 698

  Fly   853 TRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAA 910
            ....|||  ..|.|            .|:.:.:.|||:|::::|:|||.:.:.|.:|:
Human   699 LSSSSMS--LSPKL------------CAEKEAATSELQSIQRLVSGLEAKPDRSRSAS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	14/57 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	157/199 (79%)
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	160/202 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..342		19/40 (48%)
		TBX	323..411	CDD:204975	16/91 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..465		16/115 (14%)
		Transcription repression	544..695		49/191 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..707		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1123
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1962
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm40607
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850