Protein Alignment bi and TBX15

DIOPT Version :10

• Sequence 1: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_047285080.1
• Gene: TBX15 / 6913
• HGNCID: 11594
• Length: 698
• Species: Homo sapiens
• Alignment Length: 801
• Identity: 225/801 - (28%)
• Similarity: 319/801 - (39%)
• Gaps: 255/801 - (31%)

  Fly   205 PSTGAAAPPAGATGL--------PPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGP 261
            |.||.|.|...|.|.        |....|..|      ..:||...||    .||.|    |..|
Human    61 PGTGEAQPSVRAVGKESICGVRGPSWNTPEEL------ALNPALRRPP----LALKA----PVSP 111

  Fly   262 HPGLYPG------GGLRFPPHHPGAHPH--------AHHLGSAYTTAEDVVLASAVAHQLHPAMR 312
            .|   ||      ..|.|....|.:...        ......:::|..|  |||..|..:..||.
Human   112 SP---PGRAGRRKRSLNFQLQDPDSEQSTGSDSEVLTERTSCSFSTHTD--LASGAAGPVPAAMS 171

  Fly   313 PLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILL 377
            .:..:|           |.|:..|||::||.:||||:|||:||:|||.|:.:::|||...:|.:.
Human   172 SMEEIQ-----------VELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIA 225

  Fly   378 LDIVAADD--YRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISD 440
            :|||..|:  |||.:|:|:|||||.||..:|.|:||||||..:|:.||::||||.|||||||..|
Human   226 MDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELD 290

  Fly   441 KHGFVSTTILNSMHKYQPRFHLVR---ANDI---LKLPYST-FRTYVFKETEFIAVTAYQNEKIT 498
            ..|.:   ||:||||||||.|::|   ::|:   ..:|... .:|:.|.||.|..||||||::||
Human   291 DQGHI---ILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQIT 352

  Fly   499 QLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHA 563
            :||||.|||||||||:|. .|...:|:|....                      ..||
Human   353 RLKIDRNPFAKGFRDSGR-NRTGLEAIMETYA----------------------FWRP------- 387

  Fly   564 ALLDNQQDDDDKLLDVVGPPQSPLLPLSH----SLQQMHAHQHSAALAAWFNHLAGAGAGASEHA 624
                                  |:..|:.    ::|:..|.:.::           .|...::|
Human   388 ----------------------PVRTLTFEDFTTMQKQQASKKTS-----------QGYTVNQH- 418

  Fly   625 AAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAA 689
               ::...|.:...||:..   :||           .||||.:...:|||:|      :.:|::.
Human   419 ---SSETDAIELYERRVWL---MER-----------RGSTGTSPTTSSTGTP------SPSASSH 460

  Fly   690 GLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGL------------YPPPHLGLLHNPAAAAAM 742
            .|:|          |..||..   ||.|..:..|.            ||         |.|.:.|
Human   461 LLSP----------SCSPPTF---HLAPNTFNVGCRESQLCNLNLSDYP---------PCARSNM 503

  Fly   743 SPAGLNPGLLFNAQLAL------AAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGS--- 798
            :.....|||..:....|      |.|....|     ....|| |.:.|:.    :|.||||:
Human   504 AALQSYPGLSDSGYNRLQSGTTSATQPSETF-----MPQRTP-SLISGIP----TPPSLPGNSKM 558

  Fly   799 ------LG----SAFDAVTPGSNANRSGDPPGGGGG-----------------GLGGGVVENGPR 836
                  ||    |.|..|....||..|...|...||                 .|.|......||
Human   559 EAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPR 623

  Fly   837 SLSSSPRPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAG------AGVAQSQHSPSELKSMEKM 895
             |::||....||.|             ..|...|..|..|      :|:..|.|..|...:.::.
Human   624 -LAASPEKLSASQS-------------TLLCSSPSNGAFGERQYLPSGMEHSMHMISPSPNNQQA 674

  Fly   896 VNGLEVQHNGSAAAAAAALQL 916
            .|..:.:..|:...:::.:.:
Human   675 TNTCDGRQYGAVPGSSSQMSV 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:337907	15/71 (21%)
		T-box_TBX2_3-like	326..513	CDD:410314	102/195 (52%)
TBX15	XP_047285080.1	T-box_TBX15-like	170..367	CDD:410324	104/210 (50%)