DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and TBX2

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_005985.3	Gene:	TBX2 / 6909	HGNCID:	11597	Length:	712	Species:	Homo sapiens

Alignment Length:	825	Identity:	317/825 - (38%)
Similarity:	384/825 - (46%)	Gaps:	239/825 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SASAAA-HPSHHPTAAHHSPSTG-AAAPPA--GATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFP 247
            :|||.| ||.|.|..|....|.. |||.|:  .|..|||..              .|.|.|....
Human     7 AASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGA--------------LAKPLPDPGL 57

  Fly   248 AAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMR 312
            |.|.||.|.:.|....||:...   ..||.|.||                             :|
Human    58 AGAAAAAAAAAAAAEAGLHVSA---LGPHPPAAH-----------------------------LR 90

  Fly   313 PLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILL 377
            .|::|:|||: |.||||||||.|:||::|||||||||||||||:|||..|.||||||.|||||||
Human    91 SLKSLEPEDE-VEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILL 154

  Fly   378 LDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKH 442
            :|||||||.||||||||||||||||||||||||||||||.||||||.|.|:||||||||||||||
Human   155 MDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKH 219

  Fly   443 GFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPF 507
            ||   ||||||||||||||:|||||||||||||||||||.||:|||||||||:||||||||||||
Human   220 GF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPF 281

  Fly   508 AKGFRDTGAGKREKKQALM-------------SNRGSDSDKLN---------PTHVSSSRAPLHL 550
            ||||||||.|:|||::.|.             ...|::||..:         ||...::.:||.|
Human   282 AKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRL 346

  Fly   551 GHA---------------------------GRPPH---------LHPHAA--------------- 564
            ..|                           ||.|.         ..|..|
Human   347 HRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAES 411

  Fly   565 --------------LLDNQQDDDDKLLDVVGPPQ--SPLLPLSHSLQQMHAHQHSAALAAWFNHL 613
                          ..:.::.|:.:.....|..|  :||:..:.|...:.| .|...| |:.:||
Human   412 GGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGA-GHLPGL-AFSSHL 474

  Fly   614 --------AGAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRP 670
                    .|||.....|.........|..|:             |.....:...||..||.
Human   475 HGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAM-------------GMGHLLASVAGGGNGGG--- 523

  Fly   671 TSTGSPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGP-PIHPSPHLL-----PYLYPHGLYPPPH 729
               |.|    |.||...|.||.|..    |...:..| |.|.|.|:|     |.....||:|.|:
Human   524 ---GGP----GTAAGLDAGGLGPAA----SAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPY 577

  Fly   730 LGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSH--RFSP 792
            ..:....|||:|:.           |..|.||        |.||||....||..|....  ||||
Human   578 TYMAAAAAAASALP-----------ATSAAAA--------AAAAAGSLSRSPFLGSARPRLRFSP 623

  Fly   793 YSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPIS 857
            |.:|.::..:...:|.|..:  .|....||.               |..|.|.|        .::
Human   624 YQIPVTIPPSTSLLTTGLAS--EGSKAAGGN---------------SREPSPLP--------ELA 663

  Fly   858 MSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQ 902
            :.....||     ||..:.:|.|  :.:.:||:|::::|:|||.|
Human   664 LRKVGAPS-----RGALSPSGSA--KEAANELQSIQRLVSGLESQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	9/57 (16%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	160/182 (88%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	164/186 (88%)
		PHA03307	300..>467	CDD:223039	22/167 (13%)
		TBX	305..383	CDD:403708	12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..450		17/136 (13%)
		Repression domain 1 (RD1)	518..601		33/115 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..687		15/81 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1123
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1962
Isobase	1	0.950	-	0	Normalized mean entropy	S3847
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm40607
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890