Protein Alignment bi and TBX1

DIOPT Version :9

• Sequence 1: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_016884414.1
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 545
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 222/696 - (31%)
• Similarity: 284/696 - (40%)
• Gaps: 225/696 - (32%)

  Fly   175 PNNNSSSSSSNNSASAAAHPSHH----------------PTAAHHS--------------PSTGA 209
            |..::.|.:|..:|.||...:|.                |...|.|              .|.||
Human     9 PRASAFSIASLVAAEAAERTAHQGSGSSDRVKLRWLPGSPAGMHFSTVTRDMEAFTASSLSSLGA 73

  Fly   210 AA--PPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLR 272
            |.  |.|.:.|..|..|           :.|.||||.|.|.|  ||..|:| ||.|
Human    74 AGGFPGAASPGADPYGP-----------REPPPPPPRYDPCA--AAAPGAP-GPPP--------- 115

  Fly   273 FPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHP-------AMRPLRALQPEDDGVVDDPKV 330
             |||   |:|.|...|:|         .||.|....|       |..|::     .:..|....|
Human   116 -PPH---AYPFAPAAGAA---------TSAAAEPEGPGASCAAAAKAPVK-----KNAKVAGVSV 162

  Fly   331 TLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADD--YRYKFHNS 393
            .||.|.||::|::|||||::||:||:|||..:.::.|:|..|.|:||:|.|..||  |||.||:|
Human   163 QLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSS 227

  Fly   394 RWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQP 458
            .|:|||||||..|.|::.|||||..|.|||:::|||.|||||||:.|.:|.:   ||||||:|||
Human   228 SWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHI---ILNSMHRYQP 289

  Fly   459 RFHLVRAN---DILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKRE 520
            |||:|..:   |..|.....|:|:||:||.|.|||||||.:||||||.:|||||||||
Human   290 RFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRD------- 347

  Fly   521 KKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQS 585
                      .|.:.....|              ||..|...:|...::           .|..|
Human   348 ----------CDPEDWPRNH--------------RPGALPLMSAFARSR-----------NPVAS 377

  Fly   586 PLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDALRRRLQADADVERD 650
            |..|                            :|..:.||.|          ||..|.||
Human   378 PTQP----------------------------SGTEKDAAEA----------RREFQRDA----- 399

  Fly   651 GSDSSCSESVGGSTGGAFRPTSTGS---PKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPS 712
                          ||   |...|.   |.:.:....:.:..|....||..|.|....|.|..|:
Human   400 --------------GG---PAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVPLPGAPGGRPSPPN 447

  Fly   713 P-------------HLLPYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHP 764
            |             |..||.||...| ..:||....||      |..| |||..:      ..||
Human   448 PELRLEAPGASEPLHHHPYKYPAAAY-DHYLGAKSRPA------PYPL-PGLRGH------GYHP 498

  Fly   765 ALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLGSAFDAVTPGS 810
                ||:....|.||||.....:...:..:......|| .|..|||
Human   499 ----HAHPHHHHHPVSPAAAAAAAAAAAAAAANMYSSA-GAAPPGS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	17/64 (27%)
		T-box	330..513	CDD:279278	108/187 (58%)
TBX1	XP_016884414.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840