DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and eomesa

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_571754.3	Gene:	eomesa / 64603	ZFINID:	ZDB-GENE-001228-1	Length:	661	Species:	Danio rerio

Alignment Length:	775	Identity:	202/775 - (26%)
Similarity:	297/775 - (38%)	Gaps:	244/775 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 NNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTS------QKQGHHLSTTEEPPSPAGTPPPTIVGL 169
            |.|||:.:.|||..:...:..:.:..::..:|      .......|.|....:.|.|..|.....
Zfish    20 NLSSSSESTNNSPGSTQIDFQDMDRTDSEQSSGAKKFLMDDADSESFTGTKAAAAATAAPDARKS 84

  Fly   170 PPIPPPNNNSSSS---------------SSNNSASAAAHP-------------------SHHPTA 200
            .|:...::..||:               ||:..:|..|:|                   |.:.::
Zfish    85 SPVIGADDELSSTRRYNIDDLGTDRYFISSSQPSSDVANPCSLFPYGGQTGSVYSGSNGSRYSSS 149

  Fly   201 AHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALA----GSPAGP 261
            .|:    |:..||||                              |.:|..|:.:    |...|.
Zfish   150 LHY----GSVLPPAG------------------------------FSSAVCASRSQFGGGYQFGQ 180

  Fly   262 HPG-LYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVV 325
            .|| |||.        :||.       ||:.::.......||...|::...||
Zfish   181 GPGCLYPS--------YPGP-------GSSLSSMPIPGSGSAARAQVYLCNRP------------ 218

  Fly   326 DDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKF 390
                       ||.|||:..|||:|||.||:|||.:.|.::||:..|.|.:.::||.||...::|
Zfish   219 -----------LWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNLTAHYNVFVEIVLADPNHWRF 272

  Fly   391 HNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMH 454
            ...:|:..||||..|. .::|:||:||.||..||::.:||.|||||||....:......:|.|:|
Zfish   273 QGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLH 337

  Fly   455 KYQPRFHLVRANDILKLPYST---FRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGA 516
            |||||.|:|...:......|:   .:|:.|.|.:|||||||||..|||||||:|||||||||
Zfish   338 KYQPRLHIVEVTEDGVEDMSSEAKTQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRD--- 399

  Fly   517 GKREKKQALMSNRGS-----DSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKL 576
                       |..|     :||:|.|:...|.|:     |...|...:.......:|
Zfish   400 -----------NYDSMYTAPESDRLTPSPTDSPRS-----HQIVPGARYAMQPFFQDQ------- 441

  Fly   577 LDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANAS-------AE 634
                         ..::|.|.|....|.......|   |..:..||.:||.:|:|.       .:
Zfish   442 -------------FVNNLPQNHRFYGSERAVPQTN---GLLSPQSEDSAAGSASAQRWFVGPVQQ 490

  Fly   635 DALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVG----AAAAAAAAGLNPGG 695
            .....:|    |:..|...|:.|....|     .:|....|| .|:|    :|.|:.|||.: ..
Zfish   491 SGATTKL----DLSYDSEYSASSLLPYG-----IKPLPLQSP-HALGYYPDSAFASMAAGWS-SR 544

  Fly   696 GSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPHL-------GLLHNPAAAAAMSPAGLNPGLLF 753
            .|| ...::.|.|..|.|.           ||.:.       ..|.:..:.||.:.|...|.:
Zfish   545 SSY-QRKMTTGLPWSPRPS-----------PPAYTDDLLSSKDKLQDENSTAAPTAASTGPWM-- 595

  Fly   754 NAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSL--------PGSLGSAFDA 805
                    :.|             ||  |:.:.|...|.||:        ||  ||:.||
Zfish   596 --------EAP-------------PV--LKSVDSGDTSGYSMACKRRRVSPG--GSSTDA 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	15/58 (26%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	87/186 (47%)
eomesa	NP_571754.3	TBOX	210..403	CDD:238106	93/229 (41%)
eomesa	NP_571754.3	T-box_assoc	425..659	CDD:292794	57/279 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810