DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and tbx2

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001030291.1	Gene:	tbx2 / 619588	XenbaseID:	XB-GENE-1018115	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	298/768 - (38%)
Similarity:	369/768 - (48%)	Gaps:	201/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 HP-APPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLA 300
            || ..|.|..||.:|..|.|      .|..:|  .|..||...|.......|..|   ||..:..
Frog    14 HPFHAPRPADFPMSAFLAAA------QPSFFP--ALTLPPAALGKPLSDPSLAGA---AEAGLHV 67

  Fly   301 SAVAHQLHPA--MRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKF 363
            ||:.|. |.|  :|.|::|:||:: |.||||||||.|:||::|||||||||||||||:|||..|.
Frog    68 SALGHH-HQAAHLRSLKSLEPEEE-VEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKV 130

  Fly   364 RVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVS 428
            ||||||.|||||||:|||||||.||||||||||||||||||||||||||||||.||||||.|.|:
Frog   131 RVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVA 195

  Fly   429 FHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQ 493
            ||||||||||||||||   ||||||||||||||:|||||||||||||||||||.||:||||||||
Frog   196 FHKLKLTNNISDKHGF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQ 257

  Fly   494 NEKITQLKIDNNPFAKGFRDTGAGKREKKQAL---------------MSNRGSDSDKLNPTHVSS 543
            |:||||||||||||||||||||.|:|||::.|               .....||:...:|   :.
Frog   258 NDKITQLKIDNNPFAKGFRDTGNGRREKRKQLSLPSLRMYEEQCKADRDGAESDASSCDP---AP 319

  Fly   544 SRAPLHLGHAGRPPHLHPHAALLDNQQD----DDDKLLD-----------VVG---PPQSPLLPL 590
            .|..||...:..|..|..|.:   |:::    |.|:.||           .||   ||.||
Frog   320 GRDSLHSPLSTEPSPLRLHRS---NREEKFGADSDQELDRREVRTARSHSPVGHRSPPSSP---- 377

  Fly   591 SHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAED----ALRRRLQADADVERDG 651
                                 .|...|...:.....:.:..|.:|    ...|.|:.|....|..
Frog   378 ---------------------RLEDRGKDKNTPEKKSESPESRKDGGDNVFSRSLEKDKGESRRK 421

  Fly   652 SDSSCSESVGGSTGGAFRP--TSTGSPKE-AVGAAAAAAAAGL------NPGGGSYP----SPNI 703
            .||......|..:...|.|  ..|.||.. :.....:.|.:||      ||...:.|    ....
Frog   422 EDSKSDPECGSLSKETFAPLMVQTDSPPHLSASHLQSLALSGLHGQQFFNPLNAAQPLFIHPGQF 486

  Fly   704 SVGP--------------------------------------PIHPSPHLL-----PYLYPHGLY 725
            ::||                                      |.|.|.|:|     |.....||:
Frog   487 TMGPGAFSAMGMGHLLASMTGASALDNGSLSSVQGATGAATFPFHLSQHMLASQGIPMPAFGGLF 551

  Fly   726 PPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSP-LQGLKSH- 788
            |.|:..:....|||:||.                          |.:||...|.:| |...:..
Frog   552 PYPYTYMAAAAAAASAMP--------------------------ATSAATTMPRNPFLSSTRPRL 590

  Fly   789 RFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPT 853
            ||:||.:|..:..:.:.:|.|.:|:.:   ||......|.        |..|||.|....|. .:
Frog   591 RFNPYQIPVGIPPSTNLLTTGLSASLN---PGSESSKPGS--------SRESSPIPDTPGHK-RS 643

  Fly   854 RPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGS 906
            ...|:||.                  |..:.|.:||::::::|:|||.|...|
Frog   644 HSNSLSPK------------------ASMKDSINELQNIQRLVSGLESQREVS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	17/59 (29%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	160/182 (88%)
tbx2	NP_001030291.1	T-box	97..277	CDD:366363	160/182 (88%)
		T-box	99..277		158/180 (88%)
		TBX	295..370	CDD:372213	15/80 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..660		17/83 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	338	1.000	Domainoid score	I1114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1978
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm47785
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090