DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Tbx21

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_062380.2	Gene:	Tbx21 / 57765	MGIID:	1888984	Length:	530	Species:	Mus musculus

Alignment Length:	736	Identity:	198/736 - (26%)
Similarity:	262/736 - (35%)	Gaps:	286/736 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GHHLSTTEEPPSPAGTPP----------PTIVGLPPIPPPNNNSSSSSSNNSASAA--------- 191
            |..|:.||..||..|..|          |.    |....|.:..:.||.....|..
Mouse     9 GDMLTGTEPMPSDEGRGPGADQQHRFFYPE----PGAQDPTDRRAGSSLGTPYSGGALVPAAPGR 69

  Fly   192 -----AHPSHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAAL 251
                 |:|.....|....|.. ...|||||.|.||            ...:|||
Mouse    70 FLGSFAYPPRAQVAGFPGPGE-FFPPPAGAEGYPP------------VDGYPAP----------- 110

  Fly   252 AALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRA 316
                    .|..|||||                        ..||..|.:.:
Mouse   111 --------DPRAGLYPG------------------------PREDYALPAGL------------- 130

  Fly   317 LQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIV 381
               |..|.:   :|.|....||.||::..|||:|||.||:|||.:.|.|:||:..:.|.:.:|:|
Mouse   131 ---EVSGKL---RVALSNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVV 189

  Fly   382 AADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFV 445
            ..|.:.:::.:.:|:..|||:..|| .|:|:|||||.||..||::.|||.|||||||....:...
Mouse   190 LVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVT 254

  Fly   446 STTILNSMHKYQPRFHLVRAND---ILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPF 507
            ...:|.|:||||||.|:|..||   ......|....:.|:||:|||||||||.:|||||||||||
Mouse   255 QMIVLQSLHKYQPRLHIVEVNDGEPEAACSASNTHVFTFQETQFIAVTAYQNAEITQLKIDNNPF 319

  Fly   508 AKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDD 572
            |||||:    ..|...|.:.           |.|.|            ||  .|:..||.
Mouse   320 AKGFRE----NFESMYASVD-----------TSVPS------------PP--GPNCQLLG----- 350

  Fly   573 DDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDAL 637
                    |.|.||||          ::|:... :.::..|.|                ..:|.:
Mouse   351 --------GDPFSPLL----------SNQYPVP-SRFYPDLPG----------------QPKDMI 380

  Fly   638 RRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAA---AAAAAAGLNPGGGSYP 699
            .                              :|...|:|:|....|   |.:....|.|   |.|
Mouse   381 S------------------------------QPYWLGTPREHSYEAEFRAVSMKPTLLP---SAP 412

  Fly   700 SPNI-----------SVGPPIHPSPHLLPYLYPHGLYPPPHLGLLHNPAAAAAMSPAG------- 746
            .|.:           ..|.|:.|.            |||             .|||||
Mouse   413 GPTVPYYRGQDVLAPGAGWPVAPQ------------YPP-------------KMSPAGWFRPMRT 452

  Fly   747 --LNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQ------GL-----KSHRFSPY----- 793
              ::|||..:.:   ....|:|:         ..|:.||      ||     |..|.|||
Mouse   453 LPMDPGLGSSEE---QGSSPSLW---------PEVTSLQPEPSDSGLGEGDTKRRRISPYPSSGD 505

  Fly   794 -SLPGSLGSAFDAVTPGSNAN 813
             |.|....|.||..|.|...|
Mouse   506 SSSPAGAPSPFDKETEGQFYN 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	9/57 (16%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	92/186 (49%)
Tbx21	NP_062380.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		13/49 (27%)
		T-box	138..325	CDD:279278	92/186 (49%)
		T-box_assoc	<393..520	CDD:292794	38/166 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..530		25/95 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810