DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and tbx2a

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_005165613.1	Gene:	tbx2a / 573084	ZFINID:	ZDB-GENE-990917-4	Length:	690	Species:	Danio rerio

Alignment Length:	771	Identity:	304/771 - (39%)
Similarity:	375/771 - (48%)	Gaps:	215/771 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPG-AHPHAHHLGSAYTTAEDVVLASAVAHQ 306
            |..||.:|..|.|      .|..:|  .|..|   || :.|.|.|   |.:.|.:..|.:|:.|.
Zfish    21 PADFPMSAFLAAA------QPSFFP--ALTLP---PGLSKPLADH---ALSGAAEAGLHAALGHH 71

  Fly   307 LHPA--MRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLD 369
             |.|  :|..:.|:||:| |.||||||||.|:||::|||:|||||||||||:|||..|.||:|||
Zfish    72 -HQAAHLRSFKGLEPEED-VEDDPKVTLEAKELWDQFHKIGTEMVITKSGRRMFPPFKVRVNGLD 134

  Fly   370 AKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKL 434
            .|||||||:|||||||.||||||||||||||||||||||||||||||.||||||.|.|:||||||
Zfish   135 KKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKL 199

  Fly   435 TNNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQ 499
            ||||||||||   ||||||||||||||:|||||||||||||||||||.||:|||||||||:||||
Zfish   200 TNNISDKHGF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQ 261

  Fly   500 LKIDNNPFAKGFRDTGAGKREK-----KQALMSNR------------GSDSDKL----------- 536
            ||||||||||||||||.|:|||     ||..|.:.            |.|||..
Zfish   262 LKIDNNPFAKGFRDTGNGRREKSLNFRKQLAMPSMRMYDDQCKVDRDGGDSDDSSCEQTTGRDSV 326

  Fly   537 -NPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDD-DDKLLDVVGP---PQSPLLPLSH---- 592
             :||..::|  ||....:....:.:..    ||:.|. ||.::.|..|   ||||..|...
Zfish   327 HSPTGPATS--PLKFTRSREDKNFNES----DNELDQHDDGMIRVSSPEQRPQSPFSPRCEDRVK 385

  Fly   593 ---SLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDS 654
               :|::...:..|                ..|:.:|.:.....:|.|..|...|.|..:..:|
Zfish   386 DRLNLEKKGDYSDS----------------RKENDSAFSIRHLDKDKLDARNVKDQDSSKKEAD- 433

  Fly   655 SCSESVGGST----------------------------GGA-----FRPTSTG------------ 674
                |||.||                            .|.     |.|.|:|
Zfish   434 ----SVGMSTVKDGFSPLMVQTENPSHFSASHLQSLALSGLHNQHFFNPLSSGQSLLFHPGQFAM 494

  Fly   675 --SPKEAVG----AAAAAAAAGLNPG---GGSYPSPNISVGP-PIHPSPHLLPYLYPHGLYPPPH 729
              |....:|    .|:.:.|:||..|   ..|..|||    | |.|.|.|:|.   ..|:..|..
Zfish   495 TPSAFSTMGMGHLLASMSGASGLENGSLSSQSTSSPN----PFPFHLSQHMLA---SQGISMPTF 552

  Fly   730 LGLLHNP-------AAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSP-LQGLK 786
            .|||..|       ||||:..|||                         :||.....:| |...:
Zfish   553 GGLLPYPYTYMAAAAAAASALPAG-------------------------SAASSLSRNPFLNNTR 592

  Fly   787 SH-RFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHS 850
            .. |||||.:|.|...:...:|.|..:..|.:......|            |..|||.....||
Zfish   593 PRLRFSPYQIPMSFSQSSGLLTTGIPSTMSAESESSKSG------------SRESSPMSEHHSH- 644

  Fly   851 PPTRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGS 906
                             |...|...|:..:..:.|.:||::::::|:|||...:.|
Zfish   645 -----------------KTGNGQNTGSPKSSGKDSINELQNIQRLVSGLEKHRDAS 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	17/60 (28%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	158/182 (87%)
tbx2a	XP_005165613.1	TBOX	92..277	CDD:238106	163/187 (87%)
tbx2a	XP_005165613.1	TBX	297..372	CDD:204975	16/80 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1085
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1860
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm26063
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820