DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bi and Tbx20

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_919239.1	Gene:	Tbx20 / 57246	MGIID:	1888496	Length:	445	Species:	Mus musculus

Alignment Length:	441	Identity:	156/441 - (35%)
Similarity:	217/441 - (49%)	Gaps:	126/441 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 TLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADD--YRYKFHNS 393
            :||.|:||:|||:|||||:||||||:|||.::...||:|.::|||:|:|||..|:  |||.:|.|
Mouse   102 SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYRYAYHRS 166

  Fly   394 RWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQP 458
            .|:|||||||.:|.|:|:|||||.||||.::::|||.|:|||||..|:||.:   ||||||||||
Mouse   167 SWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHI---ILNSMHKYQP 228

  Fly   459 RFHLVRAND----ILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKR 519
            |.|:::..|    :|.|....|||::|.||.|.|||||||:.||:||||:|||||||||
Mouse   229 RVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD------ 287

  Fly   520 EKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQ 584
                                   |||                   |.|.:::..:.|:
Mouse   288 -----------------------SSR-------------------LTDIERESVESLI------- 303

  Fly   585 SPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDALRRRLQADADVER 649
                           .:||                   :|.:.......||.|....|.   .:.
Mouse   304 ---------------QKHS-------------------YARSPIRTYGEEDVLGEESQT---TQS 331

  Fly   650 DGSDSSCSESVG----GSTGGAFRPTSTGSPKEAVGAAAAAAAAGL-NPGGGSYPSPNISVGPPI 709
            .||..:.|:::.    .|:..:|.......|..|:|.:.|:.|..: :|..||.| |...:|.|:
Mouse   332 RGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIATPIPHPIQGSLP-PYSRLGMPL 395

  Fly   710 HPS-------------PHLLPYLYPHGLYPPPHL---GLLHNPAAAAAMSP 744
            .||             |......|.|.....|:.   ||.|   ::|.|:|
Mouse   396 TPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRH---SSAVMTP 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988
bi	NP_001259238.1	T-box	330..513	CDD:279278	112/187 (60%)
Tbx20	NP_919239.1	TBOX	98..290	CDD:238106	115/219 (53%)
Tbx20	NP_919239.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..337		6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810