DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and TBX20

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001071121.1	Gene:	TBX20 / 57057	HGNCID:	11598	Length:	447	Species:	Homo sapiens

Alignment Length:	446	Identity:	160/446 - (35%)
Similarity:	220/446 - (49%)	Gaps:	135/446 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 TLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADD--YRYKFHNS 393
            :||.|:||:|||:|||||:||||||:|||.::...||:|.:||||:|:|||..|:  |||.:|.|
Human   103 SLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRS 167

  Fly   394 RWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQP 458
            .|:|||||||.:|.|:|:|||||.||||.::::|||.|:|||||..|:||.:   ||||||||||
Human   168 SWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHI---ILNSMHKYQP 229

  Fly   459 RFHLVRAND----ILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGA--- 516
            |.|:::..|    :|.|....|||::|.||.|.|||||||:.||:||||:|||||||||:..
Human   230 RVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTD 294

  Fly   517 GKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKLLDVVG 581
            .:||..::|:...            |.:|:|:.. :.|..                     ||:|
Human   295 IERESVESLIQKH------------SYARSPIRT-YGGEE---------------------DVLG 325

  Fly   582 ------PPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDALRRR 640
                  |.:......|.:|          :|::|.
Human   326 DESQTTPNRGSAFTTSDNL----------SLSSWV------------------------------ 350

  Fly   641 LQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGL-NPGGGSYPSPNIS 704
                       |.||       |..|...|.|.    .|:|.:.|:.|..: :|..||.| |...
Human   351 -----------SSSS-------SFPGFQHPQSL----TALGTSTASIATPIPHPIQGSLP-PYSR 392

  Fly   705 VGPPIHPS-------------PHLLPYLYPHGLYPPPHL---GLLHNPAAAAAMSP 744
            :|.|:.||             |......|.|.....|:.   ||.|   ::|.|:|
Human   393 LGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRH---SSAVMTP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988
bi	NP_001259238.1	T-box	330..513	CDD:279278	113/187 (60%)
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..81
		T-box	102..288	CDD:307177	113/187 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		5/45 (11%)
		DUF853	<357..>409	CDD:331106	16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810