Protein Alignment bi and tbx3a

DIOPT Version :10

• Sequence 1: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: NP_001095140.2
• Gene: tbx3a / 556870
• ZFINID: ZDB-GENE-070209-80
• Length: 689
• Species: Danio rerio
• Alignment Length: 787
• Identity: 304/787 - (38%)
• Similarity: 380/787 - (48%)
• Gaps: 201/787 - (25%)

  Fly   195 SHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPA 259
            ::||...|..|....:|               .|..|           ||:|||.||.
Zfish    12 AYHPFLPHRGPEFAMSA---------------MLGHQ-----------PPFFPALALP------- 43

  Fly   260 GPHPGLYPGGGLRFPPHHPGA--HPHAHHLGSAYTTAEDVVLASAVAHQ-LHPAMRPLRALQPED 321
                   |.|.|..    |||  .|....|..|   ||..:..|::.|| .|  :|||:.|:||:
Zfish    44 -------PNGSLSL----PGALGKPIMEQLMGA---AETGLHFSSLGHQAAH--LRPLKTLEPEE 92

  Fly   322 DGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDY 386
            : |.|||||.||.|:|||.|||.|||||||||||:|||..|.|.:|||.|||||||:|||||||.
Zfish    93 E-VEDDPKVHLEAKELWELFHKRGTEMVITKSGRRMFPPFKVRCTGLDKKAKYILLMDIVAADDC 156

  Fly   387 RYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILN 451
            ||||||||||||||||||||||||||||||.||||||.|||:||||||||||||||||   ||||
Zfish   157 RYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVNFHKLKLTNNISDKHGF---TILN 218

  Fly   452 SMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGA 516
            ||||||||||:|||||||||||||||||||.||:|||||||||:||||||||:|||||||||||.
Zfish   219 SMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDHNPFAKGFRDTGN 283

  Fly   517 GKREKKQ--ALMSNRGSDSD--KLNPTHVSSS--RAPLHLGHAGRPPHL----HPHAA-LLDNQQ 570
            |:|||::  ||.|.|..:..  |.|.|...||  :|..........|.:    |.|.. ..|:.:
Zfish   284 GRREKRKQLALQSMRSYEEQQKKENGTSDDSSGEQASFKCFRQASSPAVSTAGHNHLKDFCDSDE 348

  Fly   571 DDDDKLLDV---VGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAA------ 626
            |.|::..|.   .||..|.:...:...:...|....:.    |.....:....||...|
Zfish   349 DSDEEDKDANAKEGPDSSKISTTTEDSKDQDAGLGKSV----FGESDSSSGRRSEKTRADSRSPI 409

  Fly   627 ---AAANASAED---ALRRRLQADAD-------------VERDGS---DSSCSESVGGSTG---- 665
               ::...|.|:   .:|...:...|             |:.||:   :.:...:.|...|
Zfish   410 TLISSTTRSGEELKSPVREPAKTTDDCRTVSKENYMPLTVQTDGAAHLNQNHLHNFGFPPGLAGQ 474

  Fly   666 ------GAFRPTSTGSPKEAVGAAAAAAAAGLNP-------------GGGSYPSPNISV--GP-P 708
                  |...|......:..:|.|.:..|||:.|             .|.|.|||:.|:  .| |
Zfish   475 QFFNHLGGAHPFLLHPSQFNMGGAFSNMAAGMGPILAAVSSGGVGSLDGSSLPSPSQSLTGAPMP 539

  Fly   709 IHPSPHLL--------PYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPA 765
            .|...|:|        |:   .||:|.|:   .:..|||||.|.|.           :...:||.
Zfish   540 FHLQQHVLASQGLAMSPF---GGLFPYPY---TYMAAAAAASSAAS-----------SSVHRHPF 587

  Fly   766 LFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGV 830
            |          :.|.|     ..|:||||||        :|...:....:..|....|..:.|..
Zfish   588 L----------SAVRP-----RLRYSPYSLP--------SVPDSTLLTTAMQPMASSGLEVKGDG 629

  Fly   831 VENGPRS--LSSSPRPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSME 893
            :...|.|  |.|....|.:.      .:|:||.|                 ...:.|.|||:|::
Zfish   630 MNTSPASAALDSEVTSRSSG------SVSLSPKT-----------------CTEKDSSSELQSIQ 671

  Fly   894 KMVNGLE 900
            ::|:|||
Zfish   672 RLVSGLE 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:337907	18/60 (30%)
		T-box_TBX2_3-like	326..513	CDD:410314	161/186 (87%)
tbx3a	NP_001095140.2	T-box_TBX2_3-like	99..280	CDD:410314	158/183 (86%)
		TBX	298..379	CDD:432659	17/80 (21%)