DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Tbx3

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_853669.1	Gene:	Tbx3 / 353305	RGDID:	735203	Length:	743	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	305/835 - (36%)
Similarity:	394/835 - (47%)	Gaps:	227/835 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 SHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPA 259
            ::||...|.:|....:|.               |..|           ||:|||..|.. .|:.|
  Rat    16 AYHPFLPHRAPDFAMSAV---------------LGHQ-----------PPFFPALTLPP-NGAAA 53

  Fly   260 GPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGV 324
            ...||..             |.|....|..|   ||..:..|::..|.|  :|||:.::||:| |
  Rat    54 LSLPGAL-------------AKPIMDQLVGA---AETGIPFSSLGPQAH--LRPLKTMEPEED-V 99

  Fly   325 VDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYK 389
            .|||||.||.|:||::|||.|||||||||||:|||..|.|.||||.|||||||:||:||||.|||
  Rat   100 EDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYK 164

  Fly   390 FHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFV--------- 445
            |||||||||||||||||||||||||||.||||||.|||:||||||||||||||||.
  Rat   165 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHAT 229

  Fly   446 --------STTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKI 502
                    :.||||||||||||||:|||||||||||||||||:|.||||||||||||:|||||||
  Rat   230 WQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKI 294

  Fly   503 DNNPFAKGFRDTGAGKREKKQ--ALMSNRGSDSDKLNPT----HVSSSRAPLH-LGHAGRP---- 556
            |||||||||||||.|:|||::  .|.|.|..|......|    ..||.:|..: ...|..|
  Rat   295 DNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKETGTSDESSSEQAAFNCFAQASSPAVST 359

  Fly   557 ------PHLHPHAALLDNQQD----------DDDKLLDVV--------GPP--QSPLLPLSHSLQ 595
                  ..|.|..|..|.:.:          |..|:....        |.|  ::.|.|...|..
  Rat   360 VGTSNLKDLCPSEAESDAEAESKEEHGPEACDTAKISTTTAEEPGRDKGSPATRAQLFPAEPSRA 424

  Fly   596 QMHAH--------QHSAALAAWFNHLAGAGAGASEHAA---AAAANASAEDALRRRLQA-DA--- 645
            :..|.        :||.|..:....:    .||.||.:   ....:|..::|  |.|.| ||
  Rat   425 RDTARLDKASPDSRHSPATISSSTRV----PGADEHRSPGREGPVSAKVDEA--RALPAKDAFAP 483

  Fly   646 -DVERDGSDSSCSESVGG-------------------------STGGAFRPTSTG---------- 674
             .|:.|.:.......:.|                         :.||||...:.|
  Rat   484 LSVQTDATAHLTQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSG 548

  Fly   675 -----SPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLP----YLYPHG-LYPPPH 729
                 |..::...|:||||.||:  |.|      :...|.|...|:|.    .:.|.| |:|.|:
  Rat   549 ASTGVSGLDSTAMASAAAAQGLS--GAS------AATLPFHLQQHVLASQGLAMSPFGSLFPYPY 605

  Fly   730 LGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYS 794
            ..:    |||||.|.|..:..:..:..|.|.:..|.|                      |:||||
  Rat   606 TYM----AAAAAASSAAASSSVHRHPFLNLNSMRPRL----------------------RYSPYS 644

  Fly   795 LPGSL--GSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLS--SSPRPRPASHSPPTRP 855
            :|..:  .|:..|....|.|:.:|...|      ...|:...|.|::  |.......|.:..:..
  Rat   645 IPVPVPDSSSLLATALPSMASAAGPLDG------KSAVLAASPASVAVDSGSELNSRSSTLSSGS 703

  Fly   856 ISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAA 910
            :|:||..                .::.:.:.|||:|::::|:|||.:.:.|.:.:
  Rat   704 VSLSPKL----------------CSEKEAATSELQSIQRLVSGLEAKPDRSCSGS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	14/57 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	157/199 (79%)
Tbx3	NP_853669.1	T-box_TBX2_3-like	101..305	CDD:410314	161/203 (79%)
		TBX	323..404	CDD:403708	14/80 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..467		17/99 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1153
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1857
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm44748
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820