DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Eomes

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_038938625.1	Gene:	Eomes / 316052	RGDID:	1359706	Length:	708	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	180/579 - (31%)
Similarity:	241/579 - (41%)	Gaps:	147/579 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PSPAGTPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHP------SHHPTAAHHSPSTGAAAPPA 214
            |..||:..|...|........:::.:..:..||||.|.|      ...|.|....||...||..|
  Rat    71 PCQAGSAEPAGAGAGAPAAMLSDADAGDTFGSASAVAKPGPPDGRKGSPCAEEELPSAATAAATA 135

  Fly   215 GAT---------GLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYP-GG 269
            ..:         .||.|.|        |..:..||.....:||||.||        |..:|| ..
  Rat   136 RYSMDSLSSERYYLPSPGP--------QGSELAAPCSLFQYPAAAGAA--------HGSVYPASN 184

  Fly   270 GLRFP-----PHHPGAHPHA------HHLGSAYTTAEDVVLASAVA--------HQLHPAMRPLR 315
            |.|:|     |  ||..|.|      ...|.|..:......:...|        .|..|...|..
  Rat   185 GARYPYGSMLP--PGGFPAAVCPPARSQFGPATGSGSGAGSSGGGAGGPGGYPYGQGSPLYGPYA 247

  Fly   316 ALQPEDD----GVVDDP------KVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDA 370
            .......    |.:..|      .|.|..:.||.|||:..|||:|||.||:|||.:.|.::||:.
  Rat   248 GTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNP 312

  Fly   371 KAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKL 434
            .|.|.:.:::|.||...::|...:|:..||||..|. .:||:||:||.||..||::.:||.||||
  Rat   313 TAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKL 377

  Fly   435 TNNISDKHGFVSTTILNSMHKYQPRFHLVRAN----DILKLPYSTFRTYVFKETEFIAVTAYQNE 495
            |||....:......:|.|:||||||.|:|...    :.|..|..| :|:.|.||:|||||||||.
  Rat   378 TNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKT-QTFTFSETQFIAVTAYQNT 441

  Fly   496 KITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGR----- 555
            .|||||||:|||||||||       ...::.:  .|::|:|.|:...|.|:. .:...||
  Rat   442 DITQLKIDHNPFAKGFRD-------NYDSMYT--ASENDRLTPSPTDSPRSH-QIVPGGRYGVQN 496

  Fly   556 ---PPHLH--PHA-------------ALLDNQQDDDDKLLDVVGPPQ------------------ 584
               .|.::  |.|             .||..||.:     :|..|||
  Rat   497 FFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSE-----EVANPPQRWLVTPVQQPVTNKLDIG 556

  Fly   585 --------SPLLPL---SHSLQQMHAHQH-----SAALAAWFNHLAGAGAGASEHAAAA 627
                    |.|||.   |..||..||..:     ..|:|.|      .|.||.:...||
  Rat   557 SYESEYSSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGW------GGRGAYQRKMAA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	17/77 (22%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	92/187 (49%)
Eomes	XP_038938625.1	T-box_TBR2	269..459	CDD:410331	92/190 (48%)
Eomes	XP_038938625.1	T-box_assoc	485..706	CDD:406561	30/136 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910