DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Tbx2

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_017452798.2	Gene:	Tbx2 / 303398	RGDID:	1311014	Length:	711	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	318/840 - (37%)
Similarity:	377/840 - (44%)	Gaps:	270/840 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SASAAA-HPSHHPTAAHHSPSTG-AAAPPA--GATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFP 247
            :|||.| ||.|.|..|....|.. |||.|:  .|..|||..              .|.|.|....
  Rat     7 AASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGA--------------LAKPLPDPGL 57

  Fly   248 AAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMR 312
            |.|.||.|.:.|....||:...   ..||.|.||                             :|
  Rat    58 AGAAAAAAAAAAAAEAGLHVSA---LGPHPPAAH-----------------------------LR 90

  Fly   313 PLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILL 377
            .|::|:|||: |.||||||||.|:||::|||||||||||||||:|||..|.||||||.|||||||
  Rat    91 SLKSLEPEDE-VEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILL 154

  Fly   378 LDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKH 442
            :|||||||.||||||||||||||||||||||||||||||.||||||.|.|:||||||||||||||
  Rat   155 MDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKH 219

  Fly   443 GFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPF 507
            ||   ||||||||||||||:|||||||||||||||||||.||:|||||||||:||||||||||||
  Rat   220 GF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPF 281

  Fly   508 AKGFRDTGAGKREKKQALM-------------SNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHL 559
            ||||||||.|:|||::.|.             ...|::||       :||..|        ||..
  Rat   282 AKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESD-------ASSCDP--------PPAR 331

  Fly   560 HPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAG----AGA 620
            .|                    ||.....|....|.:..|.:...|        |.:.    ...
  Rat   332 EP--------------------PPSPSAAPSPLRLHRARAEEKPCA--------ADSDPEPERSG 368

  Fly   621 SEHAAAAAANASAEDALRRRL-QADADVERDGSDSSCSESVGGSTGGAFR--------------- 669
            .|.|||....:|:.||...|| :.:...||...:....|...|...|.|.
  Rat   369 EERAAAPLGRSSSRDASPARLTEPERSRERRSPERGSKEPTEGGGDGPFSLRSLEKERAEARRKD 433

  Fly   670 -------------------PTSTGSPKEA------------------------------------ 679
                               .|.:.||..|
  Rat   434 EGRKDVGEGKEPSLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAM 498

  Fly   680 -----------------------VGAAAAAAAAGLNPGG-GSYPSPNISVGP-PIHPSPHLL--- 716
                                   .|.||...||||:.|| |...|...:..| |.|.|.|:|
  Rat   499 GPGAFSAMGMGHLLASVAGGGGNSGGAAPGTAAGLDAGGLGPAASAASTATPFPFHLSQHMLASQ 563

  Fly   717 --PYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPV 779
              |.....||:|.|:..:....|||:|:.           |..|.||        |.||||....
  Rat   564 GIPMPTFGGLFPYPYTYMAAAAAAASALP-----------ATSAAAA--------AAAAAGSLSR 609

  Fly   780 SPLQGLKSH--RFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSP 842
            ||..|....  |||||.:|.::..:...:|.|..|..|   .||.                |..|
  Rat   610 SPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAESS---KGGN----------------SREP 655

  Fly   843 RPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQ 902
            .|.|        .:::.....||     ||..:.:|.|  :.:.|||:|::::|:|||.|
  Rat   656 SPLP--------ELALRKVGGPS-----RGALSPSGSA--KEAASELQSIQRLVSGLESQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	9/57 (16%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	160/182 (88%)
Tbx2	XP_017452798.2	T-box_TBX2_3-like	103..287	CDD:410314	164/186 (88%)
Tbx2	XP_017452798.2	TBX	305..381	CDD:403708	20/118 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm44748
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.670