DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Tbx22

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_006257221.1	Gene:	Tbx22 / 302369	RGDID:	1589764	Length:	533	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	154/502 - (30%)
Similarity:	225/502 - (44%)	Gaps:	130/502 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 KVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADD--YRYKFH 391
            :|.|:|.|||::||.:||||:|||:||:|||.::.:|.|:|...:|.::||:|..|.  |||.:|
  Rat   106 QVELQGSDLWKRFHDIGTEMIITKAGRRMFPSVRIKVKGMDPVKQYYVILDVVPVDSKRYRYVYH 170

  Fly   392 NSRWMVAGKADPE-MPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHK 455
            :|:|||||..|.. :..|.|:|||||.:||.||::::||.::|||||..|..|.:   ||.||||
  Rat   171 SSQWMVAGNTDHSCITPRFYVHPDSPCSGENWMRQIISFDRVKLTNNEMDDKGHI---ILQSMHK 232

  Fly   456 YQPRFHLVRAND------ILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDT 514
            |:||.|:|..:.      |...|....:|:.||||||..||||||::||:||||.|||||||||.
  Rat   233 YKPRVHVVEEDSRIDLSLIQSFPTEGVKTFSFKETEFTTVTAYQNQQITKLKIDRNPFAKGFRDP 297

  Fly   515 GAGK-----------------REKKQALMSNRGSDSDKLNPTHVSSSRAPLH--LGHAGRPPHLH 560
            |..:                 .:.|..:...:...|.....|....:.:||:  |..:..||.::
  Rat   298 GRNRGVLDGFLETYPWRPSFTMDFKPFVPDTQNGSSGSSPVTSSGGAPSPLNSLLSPSCSPPTVY 362

  Fly   561 -PHAALLDNQQDDDDKLLDVVGP------------PQSPLLPLSHSLQQMHAHQHSAALAAWFNH 612
             |.:::  .....:..|.:|..|            ||..:||....|...::.|....|......
  Rat   363 IPPSSI--GMTHPETYLHNVNVPFCYRICPTNYWRPQPFVLPTPERLPSFNSSQSFPPLMMEVPL 425

  Fly   613 LAGAG---AGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTG 674
            ::..|   :.:..|          ||.....|||         ..|.|:.:.|..
  Rat   426 VSSRGFINSNSGLH----------EDCNGHCLQA---------SHSTSQMLYGLQ---------- 461

  Fly   675 SPKEAVGAAAAAAAAGLNPGGGSYPSP--NISVGPPIHPSPHLLPYLYPHGLY-----PPPHLGL 732
                             |||...:|:|  ..::..|.||         |:|.|     .||.|..
  Rat   462 -----------------NPGNIFHPNPIAQEAICCPFHP---------PNGCYRYNVSMPPRLEN 500

  Fly   733 LHNPAAAAAMSPAGLNPGLLFNAQLAL---AAQHPALFGHAYAAAGH 776
            :.|     .:|..|.|       |::.   :..|    .|.|.|..|
  Rat   501 VAN-----HLSENGTN-------QISFTGGSCDH----SHWYPAINH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988
bi	NP_001259238.1	T-box	330..513	CDD:279278	98/191 (51%)
Tbx22	XP_006257221.1	TBOX	105..300	CDD:238106	101/196 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810