back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and tbx5a

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001300611.1	Gene:	tbx5a / 30071	ZFINID:	ZDB-GENE-991124-7	Length:	492	Species:	Danio rerio

Alignment Length:	521	Identity:	173/521 - (33%)
Similarity:	251/521 - (48%)	Gaps:	148/521 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIV 381
            :|...:|:    ||.|..::||.|||::||||:|||:||:|||..|.:|:||:.|.|||||:|:|
Zfish    46 IQQGMEGI----KVYLHERELWTKFHEVGTEMIITKAGRRMFPSFKVKVTGLNPKTKYILLMDVV 106

  Fly   382 AADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVS 446
            .|||:||||.:::|.|.|||:|.||.|:|:|||||.||..||:::|||.|||||||..|..|.:
Zfish   107 PADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHI- 170

  Fly   447 TTILNSMHKYQPRFHLVRA--NDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAK 509
              |||||||||||.|:|:|  |:......:.|.|:||.||.|||||:|||.|||||||:||||||
Zfish   171 --ILNSMHKYQPRIHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAK 233

  Fly   510 GFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDD 574
            ||                 ||||..:|:
Zfish   234 GF-----------------RGSDDMELH------------------------------------- 244

  Fly   575 KLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDAL-- 637
            ::..:....:.|::|.|...|::.:.|  :..:.....|:.:||.:|:::.....:::::|.|
Zfish   245 RMSRMQSTKEYPVVPRSTVRQRVGSSQ--SPFSGDVQGLSASGAISSQYSCENGVSSTSQDLLPQ 307

  Fly   638 --------------RRRLQADAD----------VERDGSDS-------SCSESVGGSTGGAFRPT 671
                          :|:::.:..          ||...|:.       |.|:|:|.|.|..:||.
Zfish   308 SSSYHEHTQDYHCIKRKVEDECPAGEHPYKKPYVESSSSEDDHYYRPLSYSQSLGLSGGAPYRPE 372

  Fly   672 STGSPKEAVGAAAAAAAAGLNPGGGSYPSPNISV------GPPIHPSPHL--LPYLY-------- 720
            |  |.::|...|:|...          |.|..|:      |.|.:..|.:  |||.:
Zfish   373 S--SQRQACMYASAPQP----------PEPVPSLEDISWPGVPPYSVPQMERLPYQHHFSAHFAS 425

  Fly   721 -----PHGLYPPPHLGLLHNPAAAAAMSPAG----LNPGLLFNAQLALAAQHPALFGHAYAAAGH 776
                 .||:|.         .:.:...||:|    .:.||..|..|........|..|.|    |
Zfish   426 RQMPEAHGMYA---------SSVSHQCSPSGGIQSPSAGLQGNEYLYAHGLQRTLSPHQY----H 477

  Fly   777 T 777
            |
Zfish   478 T 478

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.