Protein Alignment bi and TBX21

DIOPT Version :10

• Sequence 1: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: NP_037483.1
• Gene: TBX21 / 30009
• HGNCID: 11599
• Length: 535
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 190/672 - (28%)
• Similarity: 260/672 - (38%)
• Gaps: 176/672 - (26%)

  Fly   166 IVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHSPSTGA--AAPPAGATGLPPPTPPHHL 228
            :.|..|:|         .|:...:..|.|.|.    :..|..||  |....|...|..|.|...|
Human    12 LTGTEPMP---------GSDEGRAPGADPQHR----YFYPEPGAQDADERRGGGSLGSPYPGGAL 63

  Fly   229 QQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTT 293
                      .|.||..|    |.|.| .|..|....:||.|..||   |.|....:..|..|..
Human    64 ----------VPAPPSRF----LGAYA-YPPRPQAAGFPGAGESFP---PPADAEGYQPGEGYAA 110

  Fly   294 AEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMF 358
            .:.       ...|:|..|...|| |....|....:|.|....||.||::..|||:|||.||:||
Human   111 PDP-------RAGLYPGPREDYAL-PAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMF 167

  Fly   359 PQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQW 422
            |.:.|.|:||:..:.|.:.:|:|..|.:.:::.:.:|:..|||:..|| .|:|:|||||.||..|
Human   168 PFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHW 232

  Fly   423 MQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRAND---ILKLPYSTFRTYVFKET 484
            |::.|||.|||||||....:......:|.|:||||||.|:|..||   ......|....:.|:||
Human   233 MRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQET 297

  Fly   485 EFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLH 549
            :|||||||||.:||||||||||||||||:.           ..:..:..|...|:
Human   298 QFIAVTAYQNAEITQLKIDNNPFAKGFREN-----------FESMYTSVDTSIPS---------- 341

  Fly   550 LGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLA 614
                  ||  .|:...|.             |...|||||..:.:.           :.::..|.
Human   342 ------PP--GPNCQFLG-------------GDHYSPLLPNQYPVP-----------SRFYPDLP 374

  Fly   615 GAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEA 679
            |                .|:|.:.:.....|  .||.|..:...:|  |...||.|::.|.....
Human   375 G----------------QAKDVVPQAYWLGA--PRDHSYEAEFRAV--SMKPAFLPSAPGPTMSY 419

  Fly   680 VGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPH-LGLLHNPAAAAAMS 743
            .......|     ||.| :|           .:|...|.:.|...:.|.. |.:...|..:....
Human   420 YRGQEVLA-----PGAG-WP-----------VAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRG 467

  Fly   744 PAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQ------GL-----KSHRFSPY---- 793
            |....|.|::                       |.::|::      ||     |..|.|||
Human   468 PEDQGPPLVW-----------------------TEIAPIRPESSDSGLGEGDSKRRRVSPYPSSG 509

  Fly   794 --SLPGSLGSAFDAVTPGSNAN 813
              |.|....|.||....|...|
Human   510 DSSSPAGAPSPFDKEAEGQFYN 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:337907	14/57 (25%)
		T-box_TBX2_3-like	326..513	CDD:410314	92/190 (48%)
TBX21	NP_037483.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		15/62 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..109		8/28 (29%)
		T-box_TBX21	136..326	CDD:410329	92/189 (49%)
		T-box_assoc	<394..525	CDD:465042	35/172 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..535		22/106 (21%)