DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and TBX21

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_037483.1	Gene:	TBX21 / 30009	HGNCID:	11599	Length:	535	Species:	Homo sapiens

Alignment Length:	672	Identity:	190/672 - (28%)
Similarity:	260/672 - (38%)	Gaps:	176/672 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 IVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHSPSTGA--AAPPAGATGLPPPTPPHHL 228
            :.|..|:|         .|:...:..|.|.|.    :..|..||  |....|...|..|.|...|
Human    12 LTGTEPMP---------GSDEGRAPGADPQHR----YFYPEPGAQDADERRGGGSLGSPYPGGAL 63

  Fly   229 QQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTT 293
                      .|.||..|    |.|.| .|..|....:||.|..||   |.|....:..|..|..
Human    64 ----------VPAPPSRF----LGAYA-YPPRPQAAGFPGAGESFP---PPADAEGYQPGEGYAA 110

  Fly   294 AEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMF 358
            .:.       ...|:|..|...|| |....|....:|.|....||.||::..|||:|||.||:||
Human   111 PDP-------RAGLYPGPREDYAL-PAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMF 167

  Fly   359 PQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQW 422
            |.:.|.|:||:..:.|.:.:|:|..|.:.:::.:.:|:..|||:..|| .|:|:|||||.||..|
Human   168 PFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHW 232

  Fly   423 MQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRAND---ILKLPYSTFRTYVFKET 484
            |::.|||.|||||||....:......:|.|:||||||.|:|..||   ......|....:.|:||
Human   233 MRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQET 297

  Fly   485 EFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLH 549
            :|||||||||.:||||||||||||||||:.           ..:..:..|...|:
Human   298 QFIAVTAYQNAEITQLKIDNNPFAKGFREN-----------FESMYTSVDTSIPS---------- 341

  Fly   550 LGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLA 614
                  ||  .|:...|.             |...|||||..:.:.           :.::..|.
Human   342 ------PP--GPNCQFLG-------------GDHYSPLLPNQYPVP-----------SRFYPDLP 374

  Fly   615 GAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEA 679
            |                .|:|.:.:.....|  .||.|..:...:|  |...||.|::.|.....
Human   375 G----------------QAKDVVPQAYWLGA--PRDHSYEAEFRAV--SMKPAFLPSAPGPTMSY 419

  Fly   680 VGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPH-LGLLHNPAAAAAMS 743
            .......|     ||.| :|           .:|...|.:.|...:.|.. |.:...|..:....
Human   420 YRGQEVLA-----PGAG-WP-----------VAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRG 467

  Fly   744 PAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQ------GL-----KSHRFSPY---- 793
            |....|.|::                       |.::|::      ||     |..|.|||
Human   468 PEDQGPPLVW-----------------------TEIAPIRPESSDSGLGEGDSKRRRVSPYPSSG 509

  Fly   794 --SLPGSLGSAFDAVTPGSNAN 813
              |.|....|.||....|...|
Human   510 DSSSPAGAPSPFDKEAEGQFYN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	14/57 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	92/186 (49%)
TBX21	NP_037483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		15/62 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..109		8/28 (29%)
		T-box_TBX21	136..326	CDD:410329	92/189 (49%)
		T-box_assoc	<394..525	CDD:406561	35/172 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..535		22/106 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810